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Hierbei handelt es sich jedoch um komplexe Revisionsoperationen mit hohem perioperativem Risiko, das insbesondere bei schweren Komorbidit\u00e4ten oft nicht vertretbar erscheint. Zus\u00e4tzlich wird die konservative antibiotische Therapie durch das zunehmende Auftreten von Antibiotikaresistenzen und die schwierig zu behandelnde Biofilmbildung an alloplastischem Gef\u00e4\u00dfersatzmaterial erschwert.Bakteriophagen sind Viren, die selektiv Bakterien befallen und abt\u00f6ten k\u00f6nnen. Sie stellen daher eine vielversprechende alternative antiinfektive Therapieoption dar. Obwohl das therapeutische Potenzial der Bakteriophagen bereits seit Beginn des 20. Jahrhunderts bekannt ist, existieren in der westlichen Medizin bis heute nur wenige klinische Studien zur Behandlung von Infektionen mit Bakteriophagen.Die vorliegende \u00dcbersichtsarbeit fasst Biologie, Geschichte sowie Herausforderungen der Phagentherapie zusammen und zeigt anhand von 9 in Einzelfallberichten und kleineren Fallserien publizierten Patient*innen, wie Bakteriophagen in der Therapie von Gef\u00e4\u00dfprotheseninfektionen eingesetzt werden k\u00f6nnen, um komplikative resezierende Eingriffe zu vermeiden.<\/jats:p>","DOI":"10.1055\/a-2773-1756","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T23:36:32Z","timestamp":1769211392000},"page":"413-418","source":"Crossref","is-referenced-by-count":1,"title":["Bakteriophagen in der Gef\u00e4\u00dfchirurgie \u2013 ein alternativer kurativer Therapieansatz bei Graft-Infektionen"],"prefix":"10.1055","volume":"151","author":[{"given":"Theresa","family":"Angles","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsmedizin Rostock, Deutschland","place":["Rostock"],"department":["Klinik und Poliklinik f\u00fcr Allgemein-, Viszeral-, Thorax-, Gef\u00e4\u00df- und Transplantationschirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Junghans","sequence":"additional","affiliation":[{"name":"Ferring Arzneimittel GmbH, Deutschland","place":["Kiel"],"department":["Pharmazeutische Abteilung"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3281-7512","authenticated-orcid":false,"given":"Justus","family":"Gro\u00df","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsmedizin Rostock, Deutschland","place":["Rostock"],"department":["Klinik und Poliklinik f\u00fcr Allgemein-, Viszeral-, Thorax-, Gef\u00e4\u00df- und Transplantationschirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"issue":"S 5","key":"ref1","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1016\/S0020-1383(11)70131-0","article-title":"Infections in vascular surgery","volume":"42","author":"MR Tatterton","year":"2011","journal-title":"Injury"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.3390\/antibiotics10121446","article-title":"Bacteriophages for the Treatment of Graft Infections in Cardiovascular Medicine","volume":"10","author":"S Junghans","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ejvs.2019.10.016","article-title":"Editor\u2019s Choice \u2013 European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Vascular Graft and Endograft Infections","volume":"59","author":"N Chakf\u00e9","year":"2020","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1177\/1358863X15612574","article-title":"Management of infected vascular grafts","volume":"21","author":"A Kilic","year":"2016","journal-title":"Vasc Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/S0140-6736(01)20383-3","article-title":"An Investigation On The Nature Of Ultra-Microscopic Viruses","volume":"186","author":"FW Twort","year":"1915","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.resmic.2007.07.005","article-title":"On an invisible microbe antagonistic toward dysenteric bacilli: brief note by Mr. F. 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