{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:53:58Z","timestamp":1791845638763,"version":"4.3.4"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Ziel dieser Studie ist es, die medizinischen Indikationen, Diagnoseverfahren,\nfetalen Pathologien und den Zeitpunkt von Schwangerschaftsabbr\u00fcchen aus\nmedizinischen Gr\u00fcnden ab der 12+0 SSW (p.c.) darzustellen, sowie den\nEinfluss der Einf\u00fchrung des NIPT auf den Zeitpunkt und das Muster der\nIndikationen zu untersuchen.Methoden: Retrospektive Analyse von 561\nSchwangerschaftsabbr\u00fcchen ab der 12+0 SSW an einem Universit\u00e4tsklinikum\nzwischen 2008 und 2024. Die Diagnosen basieren auf\nUltraschalluntersuchungen, invasiven pr\u00e4natalen Diagnoseverfahren und\nmolekulargenetischen Analysen.<\/jats:p>\n                  <jats:p>Die h\u00e4ufigsten Indikationen waren Chromosomenanomalien (38,1%), gefolgt von\nFehlbildungen des ZNS (22,4%) und multiplen Fehlbildungen (17,0%).\nSchwangerschaftsabbr\u00fcche vor Erreichen eines Gestationsalters von 24+0 SSW\nerfolgten signifikant fr\u00fcher und h\u00e4ufiger bei Chromosomenanomalien, w\u00e4hrend\nnach Erreichen der 24+0 SSW Fehlbildungen des ZNS dominierten.\nKomplikationen der Mutter waren insgesamt selten (4%), keine\nM\u00fcttersterblichkeit. Die Einf\u00fchrung des NIPT f\u00fchrte zu einer Vorverlagerung\nder Diagnosen chromosomaler Anomalien.<\/jats:p>\n                  <jats:p>Medizinisch indizierte Schwangerschaftsabbr\u00fcche sind sicher und weisen eine\ngeringe Komplikationsrate bei M\u00fcttern auf. Die h\u00e4ufigsten Indikationen\nbeziehen sich auf Chromosomenanomalien und Fehlbildungen des\nZentralnervensystems. Die Einf\u00fchrung des NIPT erm\u00f6glicht tendenziell eine\nfr\u00fchere Diagnose von fetalen Chromosomenanomalien. Weitere\nLangzeitbeobachtungen sind erforderlich, um die Auswirkungen des NIPT\nvollst\u00e4ndig beurteilen zu k\u00f6nnen.<\/jats:p>","DOI":"10.1055\/a-2773-3034","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:59:52Z","timestamp":1777881592000},"page":"400-410","source":"Crossref","is-referenced-by-count":0,"title":["Sp\u00e4te Schwangerschaftsabbr\u00fcche nach der 14. Schwangerschaftswoche:\nIndikation, Methodik und Komplikationen, eine retrospektive Analyse aus den\nJahren 2008\u20132024"],"prefix":"10.1055","volume":"230","author":[{"given":"Paula","family":"Hintz","sequence":"additional","affiliation":[{"name":"Frauenheilkunde & Geburtshilfe, Pr\u00e4natale Medizin\nund fetale Therapie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg Standort Gie\u00dfen,\nGiessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Bedei","sequence":"additional","affiliation":[{"name":"Frauenheilkunde & Geburtshilfe, Pr\u00e4natale Medizin\nund fetale Therapie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg Standort Gie\u00dfen,\nGiessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Z\u00f6llner","sequence":"additional","affiliation":[{"name":"Frauenheilkunde & Geburtshilfe, Pr\u00e4natale Medizin\nund fetale Therapie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellydda","family":"Widriani","sequence":"additional","affiliation":[{"name":"Frauenheilkunde & Geburtshilfe, Pr\u00e4natale Medizin\nund fetale Therapie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg Standort Gie\u00dfen,\nGiessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Axt-Fliedner","sequence":"additional","affiliation":[{"name":"Frauenheilkunde & Geburtshilfe, Pr\u00e4natale Medizin\nund fetale Therapie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg Standort Gie\u00dfen,\nGiessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Windhorst","sequence":"additional","affiliation":[{"name":"Frauenheilkunde & Geburtshilfe, Pr\u00e4natale Medizin\nund fetale Therapie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg Standort Gie\u00dfen,\nGiessen, 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