{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:32:57Z","timestamp":1793349177681,"version":"4.5.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gesundheitswesen"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Colorectal and pancreatic cancers impose profound physical, psychological, and social challenges on patients, underscoring the need for comprehensive assessments of their impact on health-related quality of life (HRQoL). This study aimed to evaluate HRQoL levels in colorectal and pancreatic cancer patients, including the comparison to the general population and the assessment of sociodemographic as well as disease- and treatment-related predictors.<\/jats:p>\n                  <jats:p>The analyses are based on data from a clinical registry of the NCT\/UCC Dresden. Patients were recruited during consultation hours between August 2020 and December 2024. Baseline quality of life data and routine data from the tumor documentation system were used. The final analytical sample comprised n=417 patients in the colorectal study group and n=193 patients in the pancreatic study group. Multivariable linear regression analyses were calculated, with results presented as regression coefficients (b) and 95% confidence intervals (CI).<\/jats:p>\n                  <jats:p>Colorectal and pancreatic cancer patients exhibited significantly lower HRQoL compared to the general population, with large differences in social function and medium differences in role function and global health. Pancreatic cancer patients reported lower HRQoL across most domains compared to colorectal cancer patients. In the colorectal study group, statutory health insurance (b=\u201314.10, CI=\u201322.54; \u20135.66), living in rural counties with some urbanization (b=\u20135.34, CI=\u201310.51; \u20130.17) and recent chemotherapy (b=\u20139.10, CI=\u201316.36; \u20131.85) predicted worse global health. With regard to pancreatic cancers, residence in rural counties with some urbanization (b=\u201310.26, CI=\u201318.93; \u20131.59) was associated with worse global health, whereas longer time since diagnosis (b=0.06, CI=0.01; 0.12) was associated with better global health.<\/jats:p>\n                  <jats:p>Sociodemographic factors were the most consistent predictors of HRQoL in patients with pancreatic and colorectal cancer. These findings suggest social disparities, particularly for patients in rural areas and those with lower socioeconomic status. Efforts to improve access to healthcare, provide psychosocial support, and manage symptom burden are critical to enhancing the quality of life for these patients.<\/jats:p>","DOI":"10.1055\/a-2776-2703","type":"journal-article","created":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:02:21Z","timestamp":1793347341000},"source":"Crossref","is-referenced-by-count":0,"title":["Health-related quality of life among patients with colorectal und pancreatic cancer: results from a monocentric registry study"],"prefix":"10.1055","author":[{"given":"Daniela","family":"Piontek","sequence":"additional","affiliation":[{"name":"Core Unit Registry Trial Platform, National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany"},{"name":"Center for Evidence-Based Healthcare (ZEGV), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-7148","authenticated-orcid":false,"given":"Olaf","family":"Schoffer","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Healthcare (ZEGV), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-5901","authenticated-orcid":false,"given":"Thomas","family":"Datzmann","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Healthcare (ZEGV), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Boehme","sequence":"additional","affiliation":[{"name":"Core Unit Data Management and Analytics, National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Distler","sequence":"additional","affiliation":[{"name":"Department for Visceral, Thoracic, and Vascular Surgery, TUD Dresden University of Technology Faculty of Medicine Carl Gustav Carus, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Fritzmann","sequence":"additional","affiliation":[{"name":"Department for Visceral, Thoracic, and Vascular Surgery, TUD Dresden University of Technology Faculty of Medicine Carl Gustav Carus, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Hempel","sequence":"additional","affiliation":[{"name":"Department for Visceral, Thoracic, and Vascular Surgery, TUD Dresden University of Technology Faculty of Medicine Carl Gustav Carus, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Oehme","sequence":"additional","affiliation":[{"name":"Department for Visceral, Thoracic, and Vascular Surgery, TUD Dresden University of Technology Faculty of Medicine Carl Gustav Carus, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Radulova-Mauersberger","sequence":"additional","affiliation":[{"name":"Department for Visceral, Thoracic, and Vascular Surgery, TUD Dresden University of Technology Faculty of Medicine Carl Gustav Carus, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Ubbelohde","sequence":"additional","affiliation":[{"name":"Medical Clinic I, TUD Dresden University of Technology Faculty of Medicine Carl Gustav Carus, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bornhaeuser","sequence":"additional","affiliation":[{"name":"Medical Clinic I, TUD Dresden University of Technology Faculty of Medicine Carl Gustav Carus, Dresden, Germany"},{"name":"National Center for Tumor Diseases (NCT), National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Weitz","sequence":"additional","affiliation":[{"name":"Department for Visceral, Thoracic, and Vascular Surgery, TUD Dresden University of Technology Faculty of Medicine Carl Gustav Carus, Dresden, Germany"},{"name":"National Center for Tumor Diseases (NCT), National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Core Unit Registry Trial Platform, National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany"},{"name":"Center for Evidence-Based Healthcare (ZEGV), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"ref1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA A Cancer J Clinicians"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/cam4.5150","article-title":"Increasing patient participation in oncology clinical trials","volume":"12","author":"J Chen","year":"2023","journal-title":"Cancer Medicine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1200\/JCO.1993.11.3.570","article-title":"The functional assessment of cancer therapy scale: development and validation of the general measure","volume":"11","author":"D F Cella","year":"1993","journal-title":"JCO"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"N K Aaronson","year":"1993","journal-title":"JNCI Journal of the National Cancer Institute"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.ejca.2005.05.007","article-title":"Health related quality of life outcomes in cancer clinical trials","volume":"41","author":"A Bottomley","year":"2005","journal-title":"European Journal of Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/PPO.0b013e3181b9c5b9","article-title":"Other paradigms: Health-related quality of life as a measure in cancer treatment: Its importance and relevance","volume":"15","author":"P C Trask","year":"2009","journal-title":"The Cancer Journal"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"12164","DOI":"10.3390\/ijerph182212164","article-title":"Impact of socioeconomic status on cancer incidence risk, cancer staging, and survival of patients with colorectal cancer under universal health insurance coverage in Taiwan","volume":"18","author":"W-Y Kuo","year":"2021","journal-title":"IJERPH"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.21037\/jgo-21-788","article-title":"Association of social determinants of health with late diagnosis and survival of patients with pancreatic cancer","volume":"13","author":"J C Fabregas","year":"2022","journal-title":"J Gastrointest Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1080\/0284186X.2018.1557785","article-title":"Systematic review of the impact of demographic and socioeconomic factors on quality of life in ostomized colorectal cancer survivors","volume":"58","author":"H\u00d8 Kristensen","year":"2019","journal-title":"Acta Oncologica"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e086544","DOI":"10.1136\/bmjopen-2024-086544","article-title":"Predictive factors associated with health-related quality of life in patients with colorectal cancer in Iran: a cross-sectional study","volume":"14","author":"A Dahouri","year":"2024","journal-title":"BMJ Open"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000098177","article-title":"Health-related quality of life in patients with pancreatic cancer","volume":"74","author":"J M\u00fcller-Nordhorn","year":"2006","journal-title":"Digestion"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.2147\/CMAR.S376261","article-title":"Health-related quality of life of patients with metastatic pancreatic cancer: A systematic literature review","volume":"14","author":"H K Yoo","year":"2022","journal-title":"CMAR"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"S226","DOI":"10.1055\/a-2129-7651","article-title":"Langzeitbeobachtung von Patienten mit Krebserkrankungen \u2013 ein entit\u00e4tsunabh\u00e4ngiges Register f\u00fcr Versorgungsforschung und translationale Forschung an der Universit\u00e4tsmedizin Dresden (Cancer-Reg-VT)","volume":"85","author":"T Datzmann","year":"2023","journal-title":"Gesundheitswesen"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1001\/jamaoncol.2017.0417","article-title":"An international collaborative standardizing a comprehensive patient-centered outcomes measurement set for colorectal cancer","volume":"3","author":"J A Zerillo","year":"2017","journal-title":"JAMA Oncol"},{"key":"ref16","volume-title":"Siedlungsstruktureller Kreistyp","author":"Bundesinstitut f\u00fcr Bau-, Stadt- und Raumforschung","year":"2023"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejca.2020.06.002","article-title":"Updated EORTC QLQ-C30 general population norm data for Germany","volume":"137","author":"S Nolte","year":"2020","journal-title":"European Journal of Cancer"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1200\/JCO.2010.28.0107","article-title":"Evidence-based guidelines for determination of sample size and interpretation of the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30","volume":"29","author":"K Cocks","year":"2011","journal-title":"JCO"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"11793","DOI":"10.3748\/wjg.v21.i41.11793","article-title":"Treatment-related gastrointestinal toxicities and advanced colorectal or pancreatic cancer: A critical update","volume":"21","author":"G Aprile","year":"2015","journal-title":"WJG"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/gutjnl-2024-333227","article-title":"Epidemiology of gastrointestinal cancers: a systematic analysis from the Global Burden of Disease Study 2021","volume":"74","author":"P Danpanichkul","year":"2025","journal-title":"Gut"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"0046958019875897","DOI":"10.1177\/0046958019875897","article-title":"Differences in perceived waiting time by health insurance type in the inpatient sector: An analysis of patients with breast cancer in Germany","volume":"56","author":"S Lee","year":"2019","journal-title":"INQUIRY"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/jrh.12074","article-title":"Quality of end-of-life care among rural Medicare beneficiaries with colorectal cancer","volume":"30","author":"S Watanabe-Galloway","year":"2014","journal-title":"The Journal of Rural Health"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1017\/S1478951517000608","article-title":"Association between pancreatic cancer patients\u2019 perception of their care coordination and patient-reported and survival outcomes","volume":"16","author":"V L Beesley","year":"2018","journal-title":"Pall Supp Care"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1188\/19.ONF.428-441","article-title":"Understanding symptom burden in patients with advanced cancer living in rural areas","author":"S Gilbertson-White","year":"2019","journal-title":"ONF"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1111\/jocn.15840","article-title":"Quality of life among ostomy patients: A narrative literature review","volume":"30","author":"A Alenezi","year":"2021","journal-title":"Journal of Clinical Nursing"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.37287\/ijghr.v7i1.5378","article-title":"Psychosocial experiences of colorectal cancer patients with stoma","volume":"7","author":"R Maria","year":"2025","journal-title":"IJGHR"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.2174\/1381612825666190717091230","article-title":"Comparison of the quality of life of cancer patients with pain treated with oral controlled-release Morphine and Oxycodone and transdermal Buprenorphine and Fentanyl","volume":"25","author":"W Leppert","year":"2019","journal-title":"CPD"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.1200\/JCO.22.02776","article-title":"Interpreting the significance of changes in health-related quality-of-life scores","volume":"41","author":"D Osoba","year":"2023","journal-title":"JCO"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12957-023-03262-9","article-title":"Treatment in certified cancer centers is related to better survival in patients with colon and rectal cancer: evidence from a large German cohort study","volume":"22","author":"V Bierbaum","year":"2024","journal-title":"World J Surg Onc"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1186\/s12885-022-09731-w","article-title":"Is treatment in certified cancer centers related to better survival in patients with pancreatic cancer? Evidence from a large German cohort study","volume":"22","author":"M Roessler","year":"2022","journal-title":"BMC Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1586\/14737167.4.2.159","article-title":"Patient recall and recall bias of health state and health status","volume":"4","author":"J K Schmier","year":"2004","journal-title":"Expert Review of Pharmacoeconomics & Outcomes Research"}],"container-title":["Das Gesundheitswesen"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2776-2703.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:02:23Z","timestamp":1793347343000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2776-2703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":30,"URL":"https:\/\/doi.org\/10.1055\/a-2776-2703","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0941-3790","1439-4421"],"issn-type":[{"value":"0941-3790","type":"print"},{"value":"1439-4421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]}}}