{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:50:28Z","timestamp":1783680628087,"version":"3.55.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"07\/08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Der vorliegende Fall berichtet \u00fcber einen Patienten mit im Erwachsenenalter\nauftretendem Morbus Alexander. Die in diesem Fall festgestellte genetische\nMutation war bisher unbekannt. Die Alexander-Krankheit ist eine sehr seltene\nLeukodystrophie, die durch Mutationen im Gen f\u00fcr das glial fibrillary acidic\nprotein (GFAP) verursacht wird. Die Symptome sind variabel und h\u00e4ngen\nhaupts\u00e4chlich von der Lokalisation ab. Prim\u00e4res Ziel der Therapie ist es, die\nSymptome zu lindern. Derzeit gibt es keine kausale Therapie.<\/jats:p>","DOI":"10.1055\/a-2777-1997","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:38:21Z","timestamp":1770421101000},"page":"314-316","source":"Crossref","is-referenced-by-count":1,"title":["Eine neue Mutation als Ursache des Alexander-Syndroms beim\nErwachsenen, aufgetreten als Tumor an der Halswirbels\u00e4ule"],"prefix":"10.1055","volume":"94","author":[{"given":"Nadja","family":"Saric","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Neurochirurgie, Gemeinschaftsklinikum\nMittelrhein gGmbH, Koblenz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Rink","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals \u2013 Nasen \u2013 Ohren \u2013\nHeilkunde, Universit\u00e4tsklinikum Regensburg, Regensburg, 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