{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:33:55Z","timestamp":1791495235926,"version":"4.3.4"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Castellano-Leonesa de Hematolog\u00eda y Hemoterapia","award":["FUCALHH 2020"],"award-info":[{"award-number":["FUCALHH 2020"]}]},{"name":"Gerencia Regional de Salud Castilla y Le\u00f3n","award":["GRS2147\/A\/2020, GRS2894\/A1\/2023"],"award-info":[{"award-number":["GRS2147\/A\/2020, GRS2894\/A1\/2023"]}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI24\/01458, PI24\/01987"],"award-info":[{"award-number":["PI24\/01458, PI24\/01987"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inherited factor VII deficiency (FVIID) presents a highly variable bleeding phenotype. The weak correlation between plasma FVII levels (FVII:C) and bleeding severity results in diverse management strategies and complicates surgical decision-making.<\/jats:p>\n                  <jats:p>To describe surgical management and bleeding outcomes in patients with FVIID, and to identify key decision-making variables and predictors of surgical bleeding.<\/jats:p>\n                  <jats:p>We conducted a multicenter, retrospective study of 380 surgeries performed in 215 patients with FVIID. Patients were classified by FVII:C levels as mild, moderate, or severe deficiency. Bleeding score (BS) was defined according to ISTH-BAT. Surgeries were categorized as low-moderate risk (LR) or high risk (HR) for bleeding. A decision-tree simulation was performed.<\/jats:p>\n                  <jats:p>Most patients had mild FVIID (76%), and 68% of surgeries were classified as LR. Prophylactic treatment with tranexamic acid (TA) and\/or rFVIIa was administered in 42.8% of LR and 62.8% of HR surgeries. Prophylaxis was given to 73.9% of moderate\/severe and 41% of mild FVIID patients, especially for HR procedures. FVII:C levels and surgical bleeding risk were key factors that influenced the selection of treatment. The overall bleeding rate was 3.1% (HR: 9%; LR: 0.4%). Most bleeding events occurred in mild FVIID patients with BS \u22653. Our algorithm recommends hemostatic treatment for all moderate\/severe, and for mild patients HR surgeries and LR procedures when BS is \u22653.<\/jats:p>\n                  <jats:p>FVII:C levels and surgery type influence prophylactic hemostatic treatment strategies. Patients with mild FVIID, higher BS, and no hemostatic treatment had a greater risk of bleeding. Bleeding score and procedural risk were identified as predictors of surgical bleeding.<\/jats:p>","DOI":"10.1055\/a-2778-4440","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T23:50:25Z","timestamp":1766620225000},"page":"809-818","source":"Crossref","is-referenced-by-count":1,"title":["Optimizing Surgical Approaches for Patients with Inherited Factor VII Deficiency"],"prefix":"10.1055","volume":"126","author":[{"given":"Pablo","family":"Garc\u00eda-Ja\u00e9n","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), Universidad de Salamanca (USAL), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Mart\u00edn de Bustamante","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Universitario La Paz, Madrid, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Nicol\u00e1s-Boluda","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda Radioter\u00e1pica, Complejo Asistencial Universitario de Salamanca (CAUSA), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Rey-Bua","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), Universidad de Salamanca (USAL), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Puerta-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), Universidad de Salamanca (USAL), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Zapata-Tapia","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), Universidad de Salamanca (USAL), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Cort\u00e9s-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Estad\u00edstica, Universidad de Salamanca (USAL), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Hortal","sequence":"additional","affiliation":[{"name":"Servicio de Pediatr\u00eda, Gerencia de Atenci\u00f3n Primaria de Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Mart\u00ednez-Robles","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital 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Herrmann","year":"2009","journal-title":"Haemophilia"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1365-2516.1997.00137.x","article-title":"Clinical manifestations in 28 Italian and Iranian patients with severe factor VII deficiency","volume":"3","author":"F Peyvandi","year":"1997","journal-title":"Haemophilia"},{"issue":"S 01","key":"ref5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1538-7836.2011.04372.x","article-title":"Gynecological and obstetrical manifestations of inherited bleeding disorders in women","volume":"9","author":"F Peyvandi","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.jtha.2023.07.014","article-title":"High prevalence of heavy menstrual bleeding in women with rare bleeding disorders in the Netherlands: retrospective data from the RBiN study","volume":"21","author":"D PMSM 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Marty","year":"2008","journal-title":"Haemophilia"},{"issue":"09","key":"ref10","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1111\/j.1538-7836.2012.04844.x","article-title":"Classification of rare bleeding disorders (RBDs) based on the association between coagulant factor activity and clinical bleeding severity","volume":"10","author":"F Peyvandi","year":"2012","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1055\/s-0033-1349221","article-title":"Rare bleeding disorders: worldwide efforts for classification, diagnosis, and management","volume":"39","author":"F Peyvandi","year":"2013","journal-title":"Semin Thromb Hemost"},{"issue":"09","key":"ref12","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/j.1538-7836.2010.03975.x","article-title":"ISTH\/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding 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