{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:00:43Z","timestamp":1791918043203,"version":"4.3.4"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with inflammatory bowel disease (IBD) frequently undergo colonoscopy, each requiring bowel preparation. European Society of Gastrointestinal Endoscopy (ESGE) 2019 guidelines recommended high- or low-volume polyethylene glycol (PEG)-based bowel prep for IBD patients; however other non-PEG-based preparations (sulphate and picosulphate-based) have now been studied in IBD.<\/jats:p>\n                  <jats:p>We searched CENTRAL, ClinicalTrials.gov, Embase, MEDLINE, and the World Health Organization International Clinical Trials Registry Platform for randomized controlled trials (RCTs) up to December 2024. Primary outcome was bowel prep success; secondary outcomes included tolerability, acceptability, cecal intubation rates (CIR) and safety. Pooled estimates used risk ratio (RR) and GRADE to assess evidence certainty.<\/jats:p>\n                  <jats:p>Ten RCTs (1479 IBD patients) were included. There was no difference in prep success (relative risk [RR] 0.98, 95% confidence interval [CI] 0.88\u20131.09; I2 = 33%, 2 RCTs; moderate certainty evidence) between 2 L vs. 4 L PEG, but higher acceptability for 2 L (RR 0.69, 95% CI 0.59\u20130.80; I2 = 18%, 2 RCTs; high certainty evidence). Low-volume non-PEG vs. PEG are probably similar for prep success (RR 0.96, 95% CI 0.90\u20131.01; I2 = 6%,3 RCTs; moderate certainty evidence). The evidence on tolerability and acceptability was very uncertain. Subgroup analysis revealed comparable effectiveness of picosulphate-based (RR 0.89, 95% CI 0.78\u20131.01; I2 = 0%,1 RCT) and sulphate-based preps (RR 0.98, 95% CI 0.91\u20131.05; I2 = 28%, 2 RCTs) compared with low-volume PEG. Safety data were inconsistently reported.<\/jats:p>\n                  <jats:p>High-certainty evidence supports low-volume PEG as comparably successful to high-volume PEG, with higher acceptability. Moderate-certainty evidence indicates similar success between non-PEG and PEG-based preps. Both low-volume PEG and non-PEG-based preps are supported for use in IBD, broadening options beyond current ESGE guidelines.<\/jats:p>","DOI":"10.1055\/a-2778-9563","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T23:52:20Z","timestamp":1766620340000},"source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Efficacy and acceptability of bowel preparation strategies for inflammatory bowel disease colonoscopy: Systematic review and meta-analysis"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4699-2263","authenticated-orcid":false,"given":"Gaurav B.","family":"Nigam","sequence":"first","affiliation":[{"name":"Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Gordon","sequence":"first","affiliation":[{"name":"School of Medicine, University of Central Lancashire, Preston, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-9406","authenticated-orcid":false,"given":"Vassiliki","family":"Sinopoulou","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Central Lancashire, Preston, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anukriti","family":"Tomar","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Central Lancashire, Preston, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahida","family":"Din","sequence":"additional","affiliation":[{"name":"Edinburgh Inflammatory Bowel Diseases Unit, Western General Hospital, Edinburgh, United Kingdom of Great Britain and Northern Ireland"},{"name":"Institute of Genetics and Cancer, University of Edinburgh Western General Hospital, Edinburgh, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Vance","sequence":"additional","affiliation":[{"name":"Wolfson Unit for Endoscopy, St. Mark's Hospital, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Wilson","sequence":"additional","affiliation":[{"name":"Wolfson Unit for Endoscopy, St. Mark's Hospital, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E","family":"East","sequence":"additional","affiliation":[{"name":"Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"British Society of Gastroenterology Colorectal IBD Surveillance Guideline Development Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S2468-1253(20)30005-4","article-title":"Colorectal cancer in Crohn\u2019s disease: a Scandinavian population-based cohort study","volume":"5","author":"O Ol\u00e9n","year":"2020","journal-title":"Lancet Gastroenterol 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Murthy","year":"2021","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"s1","DOI":"10.1136\/gutjnl-2019-318484","article-title":"British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults","volume":"68","author":"CA Lamb","year":"2019","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2147\/JMDH.S290166","article-title":"Experiences of patients undergoing bowel preparation and colonoscopy: A qualitative longitudinal study","volume":"14","author":"S Shamim","year":"2021","journal-title":"J Multidiscip Healthc"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/ibd\/izab221","article-title":"Patients prioritize a low-volume bowel preparation in colitis-associated colorectal cancer surveillance: A discrete choice experiment","volume":"28","author":"AM Wijnands","year":"2022","journal-title":"Inflamm Bowel 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Mohsen","year":"2021","journal-title":"World J Gastroenterol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1093\/ecco-jcc\/jjac080","article-title":"Efficacy, safety and tolerability of oral sulphate tablet for bowel preparation in patients with inflammatory bowel disease: A multicentre randomized controlled study","volume":"16","author":"KO Kim","year":"2022","journal-title":"J Crohns Colitis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1080\/00365521.2022.2153618","article-title":"Randomized clinical trial evaluating three low-volume preparations for colonoscopy in outpatients with Inflammatory Bowel Disease: the EII-PREP trial","volume":"58","author":"JL Rueda Garc\u00eda","year":"2023","journal-title":"Scand J Gastroenterol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"591","DOI":"10.5009\/gnl220202","article-title":"Oral sulfate solution is as effective as polyethylene glycol with ascorbic acid in a split 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Ma","year":"2023","journal-title":"J Gastrointest Oncol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.dld.2024.04.026","article-title":"Superior bowel preparation quality for colonoscopy with 1L-PEG compared to 2 L-PEG and picosulphate: Data from a large real-world retrospective outpatient cohort","volume":"56","author":"D Scalvini","year":"2024","journal-title":"Dig Liver Dis Published"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000532","article-title":"Bowel preparation efficacy and safety of 1 L vs 2 L polyethylene glycol with ascorbic acid for colonoscopy: A randomized controlled trial","volume":"14","author":"HJ Jeon","year":"2023","journal-title":"Clin Transl Gastroenterol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/ecco-jcc\/jjz040","article-title":"Efficacy, tolerability, and safety of low-volume bowel preparations for patients with inflammatory bowel diseases: The French multicentre CLEAN Study","volume":"13","author":"C Briot","year":"2019","journal-title":"J Crohns Colitis"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1053\/j.gastro.2015.04.004","article-title":"Split-dose preparations are superior to day-before bowel cleansing regimens: A meta-analysis","volume":"149","author":"M Martel","year":"2015","journal-title":"Gastroenterology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"245","DOI":"10.15403\/jgld-5433","article-title":"Strategies to improve colonoscopy preparation in inflammatory bowel disease: A systematic review and network meta-analysis of randomized trials","volume":"33","author":"A Chatterjee","year":"2024","journal-title":"J Gastrointestin Liver Dis"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.21037\/jgo-23-581","article-title":"The safety and effects of high- and low-volume polyethylene glycol bowel preparation methods before colonoscopy on bowel cleanliness: a systematic review and meta-analysis","volume":"14","author":"G Ma","year":"2023","journal-title":"J Gastrointest Oncol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1471-2288-8-79","article-title":"Undue reliance on I(2) in assessing heterogeneity may mislead","volume":"8","author":"G R\u00fccker","year":"2008","journal-title":"BMC Med Res Methodol"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010247","article-title":"Plea for routinely presenting prediction intervals in meta-analysis","volume":"6","author":"J IntHout","year":"2016","journal-title":"BMJ Open"}],"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2778-9563.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:17:20Z","timestamp":1778224640000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2778-9563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":35,"journal-issue":{"issue":"CP","published-online":{"date-parts":[[2026,1,13]]},"published-print":{"date-parts":[[2026]]}},"alternative-id":["a27789563"],"URL":"https:\/\/doi.org\/10.1055\/a-2778-9563","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12,24]]},"published":{"date-parts":[[2025,12,24]]}}}