{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:04:18Z","timestamp":1789513458230,"version":"build-2803163510"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Worldwide, one in four adults and three in four children fail to meet the physical activity targets recommended by the World Health Organization (WHO). Patients with chronic diseases and disabilities represent some of the least active populations. WHO guidelines encourage regular physical activity for individuals with disabilities, considering functional capacity and clinical status. Recommended interventions include moderate-to-vigorous activity, muscle-strengthening exercises at least twice weekly, and functional balance training at least three times per week, with specialist consultation as needed. Data on physical activity and sports participation in patients with chronic conditions such as inherited bleeding disorders are very limited. This narrative review updates the literature, focusing on von Willebrand disease and rare coagulation defects and highlighting the need for individualized, multidisciplinary recommendations to promote safe physical activity and optimize health outcomes.<\/jats:p>","DOI":"10.1055\/a-2778-9762","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:47:48Z","timestamp":1768002468000},"page":"806-815","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Exercise\/Sport on Well-Being in von Willebrand Disease and Other Congenital Bleeding Disorders: An Update"],"prefix":"10.1055","volume":"52","author":[{"given":"Anna Chiara","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Hemophilia Center, Integrated University Hospital, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Gandini","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Hemophilia Center, Integrated University Hospital, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Focosi","sequence":"additional","affiliation":[{"name":"North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Franchini","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"issue":"02","key":"ref1","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research","volume":"100","author":"C J Caspersen","year":"1985","journal-title":"Public Health Rep"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jacc.2022.07.004","article-title":"Exercise for primary and secondary prevention of cardiovascular disease: JACC Focus Seminar 1\/4","volume":"80","author":"W J Tucker","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"117577","DOI":"10.1016\/j.atherosclerosis.2024.117577","article-title":"Lifestyle factors as determinants of atherosclerotic cardiovascular health","volume":"395","author":"A Schmidt-Trucks\u00e4ss","year":"2024","journal-title":"Atherosclerosis"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1136\/bjsports-2023-107849","article-title":"Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations from 199 unique cohort studies","volume":"58","author":"J J Lang","year":"2024","journal-title":"Br J Sports Med"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1017\/S0029665123002203","article-title":"How can physical activity facilitate a sustainable future? 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