{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:04:17Z","timestamp":1789513457654,"version":"build-2803163510"},"reference-count":198,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hemophilia is a rare inherited bleeding disorder associated with recurrent musculoskeletal bleeding, chronic pain, and functional decline. Advances in prophylactic therapies, including extended half-life factors, non-factor therapies like emicizumab, and gene therapies, have fundamentally transformed care, enabling a paradigmatic shift from activity restriction to promotion. This review synthesizes recent evidence to examine the multifaceted role of physical activity (PA) in people with hemophilia (PwH), current challenges, and strategies to optimize health outcomes. PA confers substantial benefits for PwH, improving muscle strength, coordination, bone density, cardiovascular fitness, mental health, and quality of life. It modulates chronic pain through neuroplastic, anti-inflammatory, and neuroendocrine mechanisms, while exercise-derived molecules (exerkines) may directly influence cartilage health. With individualized prophylaxis and structured programming, both resistance and aerobic exercise can be prescribed safely using evidence-based risk stratification (categories I\u2013III) and comprehensive monitoring approaches, including accelerometers, questionnaires, and subjective effort scales. Persistent barriers include chronic pain, fear of injury, insufficient professional guidance, and treatment inequities, while facilitators encompass enjoyment, social support, and adequate prophylactic coverage. Therapies providing continuous hemostatic protection have further expanded safe PA opportunities, supporting participation in previously restricted activities. In this new therapeutic era, PA should be recognized as a fundamental pillar alongside medical care. Not only for musculoskeletal preservation, but also as a strategy promoting metabolic and mental health. Ensuring access for all patients to both advanced therapies and tailored PA prescription, supported by education, enabling policies, and multidisciplinary care, is essential for democratizing active lifestyles within the global hemophilia community.<\/jats:p>","DOI":"10.1055\/a-2778-9890","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T23:55:51Z","timestamp":1766793351000},"page":"790-805","source":"Crossref","is-referenced-by-count":0,"title":["Physical Activity in People with Hemophilia"],"prefix":"10.1055","volume":"52","author":[{"given":"Carlos","family":"Cruz-Montecinos","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Medicine, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Calatayud","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Louis","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Working Environment, National Research Centre for the Working Environment, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Daffunchio","sequence":"additional","affiliation":[{"name":"Department of Traumatology, Juan A. Fern\u00e1ndez Hospital, Caba, Argentina"},{"name":"Haemophilia Foundation, Caba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Soto-Arellano","sequence":"additional","affiliation":[{"name":"Department of Hematolog\u00eda, Hospital Puerto Montt Dr. Eduardo Sch\u00fctz Schroeder, Puerto Montt, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Hematolog\u00eda, Cl\u00ednica Alemana, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"P\u00e9rez-Alenda","sequence":"additional","affiliation":[{"name":"Physiotherapy in Motion, Multispecialty Research Group (PTinMOTION), Department of Physiotherapy, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Chimeno-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Physiotherapy in Motion, Multispecialty Research Group (PTinMOTION), Department of Physiotherapy, University of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Stephensen","sequence":"additional","affiliation":[{"name":"School of Nursing, Midwifery, Allied and Public Health, Canterbury Christ Church University, Canterbury, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"N\u00fa\u00f1ez-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Medicine, University of Chile, Santiago, 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Haemost"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"540","DOI":"10.7326\/M19-1208","article-title":"Establishing the prevalence and prevalence at birth of hemophilia in males: a meta-analytic approach using national registries","volume":"171","author":"A Iorio","year":"2019","journal-title":"Ann Intern Med"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/hae.14750","article-title":"How mild is mild haemophilia?","volume":"29","author":"C Daffunchio","year":"2023","journal-title":"Haemophilia"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/hae.14646","article-title":"Exercise capacity in people with haemophilia: a systematic review","volume":"28","author":"C Cruz-Montecinos","year":"2022","journal-title":"Haemophilia"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/hae.12034","article-title":"Quadriceps strength, inter-extremity 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Wagner","year":"2020","journal-title":"Haemophilia"},{"issue":"04","key":"ref33","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/hae.15067","article-title":"Effects of resistance training on muscle strength in adults with haemophilia: a systematic review and meta-analysis","volume":"30","author":"R N\u00fa\u00f1ez-Cort\u00e9s","year":"2024","journal-title":"Haemophilia"},{"issue":"07","key":"ref34","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd.2018.70","article-title":"Advances and innovations in haemophilia treatment","volume":"17","author":"R Peters","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(24)02139-1","article-title":"Haemophilia","volume":"405","author":"P Chowdary","year":"2025","journal-title":"Lancet"},{"issue":"04","key":"ref36","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/hae.70015","article-title":"Haemophilia prophylaxis in the age of innovation: exploring opportunities for personalized treatment","volume":"31","author":"Y Dargaud","year":"2025","journal-title":"Haemophilia"},{"issue":"04","key":"ref37","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/hae.14282","article-title":"A systematic review of physical activity in people with haemophilia and its relationship with bleeding phenotype and treatment regimen","volume":"27","author":"M Kennedy","year":"2021","journal-title":"Haemophilia"},{"issue":"03","key":"ref38","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/hae.14776","article-title":"Factors associated with physical activity in young people with haemophilia A on prophylaxis","volume":"29","author":"R ED Matlary","year":"2023","journal-title":"Haemophilia"},{"issue":"04","key":"ref39","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1111\/hae.13283","article-title":"Top-level sport in athletes with severe haemophilia A","volume":"23","author":"J R Gonzalez-Porras","year":"2017","journal-title":"Haemophilia"},{"issue":"01","key":"ref40","first-page":"e2022129","article-title":"Eligibility for competitive sport medical certification of children with severe hemophilia: Italian observational study","volume":"93","author":"G Lassandro","year":"2022","journal-title":"Acta Biomed"},{"issue":"05","key":"ref41","doi-asserted-by":"crossref","first-page":"B209","DOI":"10.1093\/gerona\/56.5.B209","article-title":"Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health","volume":"56","author":"V A Hughes","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"12","key":"ref42","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1007\/s11136-016-1349-8","article-title":"Associations between daily physical activity, handgrip strength, muscle mass, physical performance and quality of life in prefrail and frail community-dwelling older adults","volume":"25","author":"S Haider","year":"2016","journal-title":"Qual Life Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"103045","DOI":"10.1016\/j.jelekin.2025.103045","article-title":"Vigorous physical activity enhances intermuscular coordination between ankle muscles during gait","volume":"84","author":"C Cruz-Montecinos","year":"2025","journal-title":"J Electromyogr Kinesiol"},{"issue":"09","key":"ref44","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/jor.70007","article-title":"Reduced muscle strength can alter the impact of gait modifications on knee cartilage mechanics","volume":"43","author":"J PJ Peitola","year":"2025","journal-title":"J Orthop Res"},{"issue":"02","key":"ref45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.joca.2014.10.008","article-title":"Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis. A systematic review and meta-analysis","volume":"23","author":"B E \u00d8iestad","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"S 04","key":"ref46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2516.2008.01732.x","article-title":"Physiopathology of haemophilic arthropathy","volume":"14","author":"F PJG Lafeber","year":"2008","journal-title":"Haemophilia"},{"issue":"03","key":"ref47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2516.2006.01214.x","article-title":"Exercise may decrease further destruction in the adult haemophilic joint","volume":"12","author":"S Harris","year":"2006","journal-title":"Haemophilia"},{"issue":"01","key":"ref48","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1365-2516.2002.00575.x","article-title":"The effect of resistance training on the frequency of bleeding in haemophilia patients: a pilot study","volume":"8","author":"R Tiktinsky","year":"2002","journal-title":"Haemophilia"},{"issue":"11","key":"ref49","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s00256-022-04266-4","article-title":"Muscle strength and osteoarthritis of the knee: a systematic review and meta-analysis of longitudinal studies","volume":"52","author":"B E Patterson","year":"2023","journal-title":"Skeletal Radiol"},{"issue":"16","key":"ref50","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1136\/bjsports-2022-106142","article-title":"Gait, physical activity and tibiofemoral cartilage damage: a longitudinal machine learning analysis in the Multicenter Osteoarthritis Study","volume":"57","author":"K E Costello","year":"2023","journal-title":"Br J Sports Med"},{"issue":"09","key":"ref51","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/ptj\/pzaa106","article-title":"Safety and effectiveness of progressive moderate-to-vigorous intensity elastic resistance training on physical function and pain in people with hemophilia","volume":"100","author":"J Calatayud","year":"2020","journal-title":"Phys Ther"},{"issue":"03","key":"ref52","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/hae.14539","article-title":"Muscle thickness and pennation angle in overweight persons with moderate haemophilia A after resistance and combined training: a randomized controlled trial","volume":"28","author":"B Parhampour","year":"2022","journal-title":"Haemophilia"},{"issue":"01","key":"ref53","doi-asserted-by":"crossref","first-page":"100401","DOI":"10.1016\/j.jnha.2024.100401","article-title":"Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)","volume":"29","author":"M Izquierdo","year":"2025","journal-title":"J Nutr Health Aging"},{"issue":"05","key":"ref54","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41574-022-00641-2","article-title":"Exerkines in health, resilience and disease","volume":"18","author":"L S Chow","year":"2022","journal-title":"Nat Rev Endocrinol"},{"issue":"04","key":"ref55","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/os.14365","article-title":"The role of exerkines in the treatment of knee osteoarthritis: from mechanisms to exercise strategies","volume":"17","author":"Y Xu","year":"2025","journal-title":"Orthop Surg"},{"issue":"04","key":"ref56","doi-asserted-by":"crossref","first-page":"e257","DOI":"10.1111\/hae.13764","article-title":"The effects of six-week resistance, aerobic and combined exercises on the pro-inflammatory and anti-inflammatory markers in overweight patients with moderate haemophilia A: a randomized controlled trial","volume":"25","author":"B Parhampour","year":"2019","journal-title":"Haemophilia"},{"issue":"02","key":"ref57","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and central sensitization in chronic and widespread pain","volume":"129","author":"R R Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"152377","DOI":"10.1016\/j.semarthrit.2024.152377","article-title":"Effects of exercise-based interventions on inflammatory markers in patients with fibromyalgia: a systematic review and meta-analysis","volume":"65","author":"L Suso-Mart\u00ed","year":"2024","journal-title":"Semin Arthritis Rheum"},{"issue":"03","key":"ref59","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11306-025-02260-0","article-title":"Exercise intensity determines circulating levels of Lac-Phe and other exerkines: a randomized crossover trial","volume":"21","author":"D Weber","year":"2025","journal-title":"Metabolomics"},{"issue":"01","key":"ref60","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3233\/BPL-220137","article-title":"High intensity acute aerobic exercise elicits alterations in circulating and skeletal muscle tissue expression of neuroprotective exerkines","volume":"8","author":"C E Mazo","year":"2022","journal-title":"Brain Plast"},{"issue":"01","key":"ref61","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jesf.2023.11.002","article-title":"Acute effect of exercise intensity on circulating FGF-21, FSTL-1, cathepsin B, and BDNF in young men","volume":"22","author":"M Ji","year":"2024","journal-title":"J Exerc Sci Fit"},{"issue":"01","key":"ref62","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/eurjpc\/zwae295","article-title":"Intensity or volume: the role of physical activity in longevity","volume":"32","author":"F Schwendinger","year":"2025","journal-title":"Eur J Prev Cardiol"},{"issue":"06","key":"ref63","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jshs.2024.04.007","article-title":"Exerkine response to acute exercise: still much to discover","volume":"13","author":"P L Valenzuela","year":"2024","journal-title":"J Sport Health Sci"},{"issue":"07","key":"ref64","doi-asserted-by":"crossref","first-page":"e23596","DOI":"10.1096\/fj.202301619R","article-title":"Beyond muscles: investigating immunoregulatory myokines in acute resistance exercise\u2014a systematic review and meta-analysis","volume":"38","author":"M Ringleb","year":"2024","journal-title":"FASEB J"},{"issue":"02","key":"ref65","doi-asserted-by":"crossref","first-page":"e260","DOI":"10.1111\/hae.14259","article-title":"Lower physical activity and altered body composition in patients with haemophilia compared with healthy controls","volume":"27","author":"P Putz","year":"2021","journal-title":"Haemophilia"},{"issue":"01","key":"ref66","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1139\/h06-113","article-title":"Physical activity in prevention and treatment of the metabolic syndrome","volume":"32","author":"T A Lakka","year":"2007","journal-title":"Appl Physiol Nutr 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Chantrain","year":"2023","journal-title":"Haemophilia"},{"issue":"02","key":"ref71","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3390\/jfmk10020183","article-title":"Physical activity as a central pillar of lifestyle modification in the management of chronic musculoskeletal pain: a narrative review","volume":"10","author":"R N\u00fa\u00f1ez-Cort\u00e9s","year":"2025","journal-title":"J Funct Morphol Kinesiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0140-6736(15)01123-X","article-title":"The past and future of haemophilia: diagnosis, treatments, and its complications","volume":"388","author":"F Peyvandi","year":"2016","journal-title":"Lancet"},{"issue":"02","key":"ref73","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/hae.14201","article-title":"Clinical phenotype of severe and moderate haemophilia: who should receive prophylaxis and what is the target trough level?","volume":"27","author":"P W Collins","year":"2021","journal-title":"Haemophilia"},{"issue":"04","key":"ref74","doi-asserted-by":"crossref","first-page":"420","DOI":"10.56875\/2589-0646.1091","article-title":"Analysis of macrophage migration inhibitory factor genotype in hemophilia a patients","volume":"16","author":"M A Hadi","year":"2023","journal-title":"Hematol Oncol Stem Cell Ther"},{"issue":"03","key":"ref75","doi-asserted-by":"crossref","first-page":"174","DOI":"10.21037\/tp.2017.04.07","article-title":"Sports participation recommendations for patients with bleeding disorders","volume":"6","author":"C Howell","year":"2017","journal-title":"Transl Pediatr"},{"issue":"05","key":"ref76","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/ejh.13494","article-title":"Life expectancy and cause of death in individuals with haemophilia A and B in Norway, 1986-2018","volume":"105","author":"K Skjefstad","year":"2020","journal-title":"Eur J 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Baumgardner","year":"2013","journal-title":"Haemophilia"},{"issue":"03","key":"ref105","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/hae.13441","article-title":"Movement behaviour in adults with haemophilia compared to healthy adults","volume":"24","author":"M A Timmer","year":"2018","journal-title":"Haemophilia"},{"issue":"02","key":"ref106","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/hae.14752","article-title":"Physical activity in Norwegian teenagers and young adults with haemophilia A compared to general population peers","volume":"29","author":"R ED Matlary","year":"2023","journal-title":"Haemophilia"},{"issue":"06","key":"ref107","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/jth.15723","article-title":"Risk factors for bleeding in people living with hemophilia A and B treated with regular prophylaxis: a systematic review of the literature","volume":"20","author":"F Germini","year":"2022","journal-title":"J Thromb 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Buckner","year":"2017","journal-title":"Patient Prefer Adherence"},{"issue":"12","key":"ref123","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jsams.2024.11.004","article-title":"Physical activity and exercise intensity terminology: a joint American College of Sports Medicine (ACSM) expert statement and Exercise and Sport Science Australia (ESSA) consensus statement","volume":"28","author":"D J Bishop","year":"2025","journal-title":"J Sci Med Sport"},{"issue":"21","key":"ref124","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1136\/bjsports-2018-099153","article-title":"What is the effect of aerobic exercise intensity on cardiorespiratory fitness in those undergoing cardiac rehabilitation? 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E Sallis","year":"2009","journal-title":"Br J Sports Med"},{"issue":"06","key":"ref134","doi-asserted-by":"crossref","first-page":"afac143","DOI":"10.1093\/ageing\/afac143","article-title":"The role of resistance exercise training for improving cardiorespiratory fitness in healthy older adults: a systematic review and meta-analysis","volume":"51","author":"T FF Smart","year":"2022","journal-title":"Age Ageing"},{"issue":"01","key":"ref135","doi-asserted-by":"crossref","first-page":"104498","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104498","article-title":"Combined aerobic and resistance training for cardiorespiratory fitness, muscle strength, and walking capacity after stroke: a systematic review and meta-analysis","volume":"29","author":"J Lee","year":"2020","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"10","key":"ref136","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/bjsports-2024-108947","article-title":"Impact of resistance training on cardiometabolic 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Strike","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"01","key":"ref140","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.semarthrit.2017.03.007","article-title":"The role of muscle strengthening in exercise therapy for knee osteoarthritis: a systematic review and meta-regression analysis of randomized trials","volume":"47","author":"C Bartholdy","year":"2017","journal-title":"Semin Arthritis Rheum"},{"issue":"03","key":"ref141","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2165\/00007256-200737030-00004","article-title":"The influence of frequency, intensity, volume and mode of strength training on whole muscle cross-sectional area in humans","volume":"37","author":"M Wernbom","year":"2007","journal-title":"Sports Med"},{"issue":"06","key":"ref142","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s40279-024-02006-3","article-title":"Dose-response modelling of resistance exercise across outcome domains in strength and 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limitation?","volume":"4","author":"C E Pfeifer","year":"2022","journal-title":"Sports Med Health Sci"},{"issue":"03","key":"ref149","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s40279-024-02143-9","article-title":"Optimising the dose of static stretching to improve flexibility: a systematic review, meta-analysis and multivariate meta-regression","volume":"55","author":"L A Ingram","year":"2025","journal-title":"Sports Med"},{"issue":"03","key":"ref151","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s40279-022-01804-x","article-title":"Resistance training induces improvements in range of motion: a systematic review and meta-analysis","volume":"53","author":"S Alizadeh","year":"2023","journal-title":"Sports Med"},{"issue":"04","key":"ref152","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3390\/healthcare9040427","article-title":"Strength training versus stretching for improving range of motion: a systematic review and 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Gallach","year":"2008","journal-title":"Haemophilia"},{"issue":"03","key":"ref156","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1111\/hae.13955","article-title":"Effects of performing dual tasks on postural sway and postural control complexity in people with haemophilic arthropathy","volume":"26","author":"C Cruz-Montecinos","year":"2020","journal-title":"Haemophilia"},{"issue":"04","key":"ref157","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/hae.13484","article-title":"Postural control during a transition task in haemophilic children, adolescents and young adults with haemophilic ankle arthropathy","volume":"24","author":"K Deschamps","year":"2018","journal-title":"Haemophilia"},{"issue":"03","key":"ref158","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/hae.14556","article-title":"Effectiveness of physical exercise on postural balance in patients with haemophilia: a systematic review","volume":"28","author":"A Chimeno-Hern\u00e1ndez","year":"2022","journal-title":"Haemophilia"},{"issue":"03","key":"ref159","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/hae.70040","article-title":"Multimodal exercise program of balance and strength improves dynamic balance, strength and functionality and decreases the risk of falls in adults with haemophilia","volume":"31","author":"A Chimeno-Hern\u00e1ndez","year":"2025","journal-title":"Haemophilia"},{"issue":"16","key":"ref160","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/bjsports-2021-104957","article-title":"I'm active enough in my job.\u201d Why is occupational physical activity not enough?","volume":"56","author":"R Shala","year":"2022","journal-title":"Br J Sports Med"},{"issue":"03","key":"ref161","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/bjsports-2017-097965","article-title":"The physical activity paradox: six reasons why occupational physical activity (OPA) does not confer the cardiovascular 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Coelho-J\u00fanior","year":"2025","journal-title":"Ageing Res Rev"},{"issue":"01","key":"ref187","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40798-024-00689-6","article-title":"Powerpenia should be considered a biomarker of healthy aging","volume":"10","author":"S R Freitas","year":"2024","journal-title":"Sports Med Open"},{"issue":"06","key":"ref188","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/jcsm.12477","article-title":"The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years","volume":"10","author":"C Suetta","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"04","key":"ref189","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1007\/s11357-025-01536-6","article-title":"Role for neurological and immunological resilience in the pathway of the aging muscle powerpenia: InCHIANTI study longitudinal results","volume":"47","author":"R 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Tyrrell","year":"2024","journal-title":"Res Pract Thromb Haemost"},{"issue":"07","key":"ref193","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.jtha.2024.04.019","article-title":"Application of machine learning approaches for predicting hemophilia A severity","volume":"22","author":"A Rawal","year":"2024","journal-title":"J Thromb Haemost"},{"issue":"09","key":"ref194","doi-asserted-by":"crossref","first-page":"e70046","DOI":"10.1002\/hsr2.70046","article-title":"Proteomic exploration of potential blood biomarkers in haemophilic arthropathy","volume":"7","author":"N Kalebota","year":"2024","journal-title":"Health Sci Rep"},{"issue":"06","key":"ref195","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1365-2516.2010.02278.x","article-title":"Muscle bleeds in professional athletes\u2014diagnosis, classification, treatment and potential impact in patients with haemophilia","volume":"16","author":"R 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