{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:08:48Z","timestamp":1789600128916,"version":"build-2803163510"},"reference-count":165,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Essential tremor is a chronic, progressive neurological disease, or perhaps a family of diseases, whose clinical characteristics place it among the disorders of involuntary movement, and more specifically, among the tremor disorders. Its underlying pathology places it within the disorders of cerebellar degeneration. Its core clinical feature, among many potential clinical features, is a 4 to 12\u2009Hz simple kinetic tremor of the arms, which is a tremor that occurs during voluntary movements such as eating, drinking, or writing. This review summarizes current understanding of the epidemiology, health care costs, clinical features (motor features; nonmotor features; and associated embarrassment, functional disability, impaired quality of life, and caregiver burden), clinical considerations (stratification points, putative staging scheme), diagnosis (based on clinical findings and more recently, grounded in postmortem findings in the cerebellum), associations with other neurodegenerative diseases (Parkinson's disease and dementia), pathophysiology (focusing on the observed neurodegenerative changes in the cerebellar cortex), and treatment.<\/jats:p>","DOI":"10.1055\/a-2779-4908","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:04Z","timestamp":1767139204000},"page":"425-435","source":"Crossref","is-referenced-by-count":1,"title":["Update on Essential Tremor"],"prefix":"10.1055","volume":"46","author":[{"given":"Elan D.","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States"},{"name":"Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/jnnp.2010.229740","article-title":"Estimating annual rate of decline: prospective, longitudinal data on arm tremor severity in two groups of essential tremor cases","volume":"82","author":"E D Louis","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1136\/jnnp.2005.086579","article-title":"Essential tremor: predictors of disease progression in a clinical cohort","volume":"77","author":"J D Putzke","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1212\/cont.0000000000001605","article-title":"Essential tremor","volume":"31","author":"L C Shih","year":"2025","journal-title":"Continuum (Minneap Minn)"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000356351","article-title":"\u2018Essential tremor\u2019 or \u2018the essential tremors\u2019: is this one disease or a family of diseases?","volume":"42","author":"E D Louis","year":"2014","journal-title":"Neuroepidemiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/bs.irn.2022.02.001","article-title":"Is essential tremor a family of diseases or a syndrome? 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