{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:58:07Z","timestamp":1781218687008,"version":"3.54.1"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontitis is a common chronic inflammatory disease that leads to the progressive destruction of periodontal tissues. Traditional treatments focus on mechanical debridement; however, antioxidants are increasingly being considered as adjuvant therapies to improve clinical outcomes. Mangosteen (Garcinia mangostana L.), a tropical fruit and chemically characterized natural source of xanthones, exhibits potent antioxidant, anti-inflammatory, and antimicrobial properties, making it a promising candidate in phytotherapeutic periodontal interventions.<\/jats:p>\n                  <jats:p>This systematic review aimed to assess the clinical and biochemical effects of mangosteen-based treatments in patients with periodontitis, compared to placebo or conventional therapies.<\/jats:p>\n                  <jats:p>Following PRISMA guidelines, a comprehensive search was conducted in PubMed, Web of Science, and Scopus. Eligible studies included randomized controlled trials, cohort studies, and clinical trials that evaluated the effects of mangosteen on periodontal parameters\u2013probing pocket depth (PPD), plaque index (PI), gingival index (GI), clinical attachment level (CAL), and bleeding on probing (BOP)\u2013as well as biochemical markers such as IL-6, TNF-\u03b1, MMP-8, MMP-9, total antioxidant capacity (TAOC), and oxidative stress indicators.<\/jats:p>\n                  <jats:p>Ten studies met the inclusion criteria, involving 422 patients. The use of 4% mangosteen gel as an adjuvant to scaling and root planing (SRP) showed significant clinical improvements in PPD, GI, CAL, and BOP. Biochemically, reductions in IL-6 and MMP-9 and increased TAOC were observed. However, heterogeneity in formulations and methodologies limited comparability.<\/jats:p>","DOI":"10.1055\/a-2779-9057","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:15:34Z","timestamp":1767053734000},"page":"717-729","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Antioxidant Mangosteen on Clinical and Biochemical Parameters of Periodontitis\u2013A Systematic Review"],"prefix":"10.1055","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3054-997X","authenticated-orcid":false,"given":"Cristina","family":"Estornut","sequence":"additional","affiliation":[{"name":"Universidad Europea de Valencia, Faculty of Health Sciences, Department of Dentistry, Valencia, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-2479","authenticated-orcid":false,"given":"Nicla","family":"Flacco","sequence":"additional","affiliation":[{"name":"Universidad Europea de Valencia, Faculty of Health Sciences, Department of Dentistry, Valencia, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Estornut","sequence":"additional","affiliation":[{"name":"Generalitat Valenciana Conselleria d\u02bcEducacio Cultura Universitats i Ocupaci\u00f3, Valencia, Valencian Community, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-3449","authenticated-orcid":false,"given":"Mart\u00edn","family":"P\u00e9rez-Leal","sequence":"additional","affiliation":[{"name":"Universidad Europea de Valencia, Faculty of Health Sciences, Department of Dentistry, Valencia, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1186\/s12903-025-06108-w","article-title":"Global, regional, and National levels and trends in burden of dental caries and periodontal disease from 1990 to 2035: Result from the global burden of disease study 2021","volume":"25","author":"J Wu","year":"2025","journal-title":"BMC Oral Health"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/prd.12337","article-title":"A public health approach for prevention of periodontal disease","volume":"84","author":"C Janakiram","year":"2000","journal-title":"Periodontol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/JPER.17-0721","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the classification of periodontal and peri-implant diseases and conditions","volume":"89","author":"P N Papapanou","year":"2018","journal-title":"J Periodontol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3390\/medicina56060272","article-title":"Periodontitis, low-grade inflammation and systemic health: A scoping review","volume":"56","author":"G Cecoro","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"T Kwon","year":"2021","journal-title":"Int Dent J"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1177\/0022034510375830","article-title":"Oxidative stress, systemic inflammation, and severe periodontitis","volume":"89","author":"F D\u02bcAiuto","year":"2010","journal-title":"J Dent Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3290\/j.qi.a42292","article-title":"Nonsurgical periodontal therapy based on the principles of cause-related therapy: Rationale and case series","volume":"50","author":"T Kwon","year":"2019","journal-title":"Quintessence Int"},{"key":"ref8","first-page":"21","article-title":"Successful nonsurgical management of post-orthodontic gingival enlargement with cause-related intensive periodontal therapy","volume":"81","author":"T Kwon","year":"2015","journal-title":"N Y State Dent J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3290\/j.ohpd.a44728","article-title":"Home care is therapeutic. 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