{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:24:06Z","timestamp":1787095446603,"version":"build-2736575974"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Available products for the treatment of von Willebrand disease (VWD) now include a new recombinant von Willebrand factor (rVWF) in addition to plasma-derived concentrates (pdVWF). However, these two therapies have never been compared directly in either preclinical studies or real-world inpatient settings.<\/jats:p>\n                  <jats:p>The Hopscotch Will II study examined the treatment of VWD in hospitals and compared the use of pdVWF and rVWF.<\/jats:p>\n                  <jats:p>Five Rare Bleeding Diseases Centers in Western France retrospectively included patients with VWD over a 48-month period. The data was collected from the BERHLINGO Research Database as well as the French Hospital database, which contains medical information from patient records.<\/jats:p>\n                  <jats:p>Of the 866 patients evaluated in the study, 285 underwent 648 hospitalizations; 126 adult patients (VWD type 3 excluded) were given VWF concentrates during 249 of those hospital stays. rVWF was used in 61% of the cases. The majority of the hospitalizations were motivated by cutaneous-mucosal symptoms in gastroenterology, stomatology, gynecology, and obstetrics. Consumption of rVWF was lower, though the difference in total VWF consumption per stay or per patient per year was not significant: 51 (57)\/34 (30) IU\/kg\/patient\/year for pdVWF versus 40 (47)\/27 (26) for rVWF (mean [SD]\/median [IQR], Wilcoxon's rank sum test, p\u2009=\u20090.2025).<\/jats:p>\n                  <jats:p>rVWF was used in similar patient profiles and for identical procedures, but the cost of treatment with rVWF was significantly lower, regardless of whether or not FVIII was added.<\/jats:p>","DOI":"10.1055\/a-2779-9176","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:45:44Z","timestamp":1768347944000},"page":"723-731","source":"Crossref","is-referenced-by-count":2,"title":["Vonicog Alfa versus Plasma-Derived von Willebrand Factor during Hospitalization: Results of an Observational Retrospective Multicenter Study"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-5952","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Horvais","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Unit\u00e9 d'Investigation Clinique 17, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ternisien","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-6681","authenticated-orcid":false,"given":"Julien","family":"Denis-Le-S\u00e8ve","sequence":"additional","affiliation":[{"name":"CHU Angers, Centre de Traitement des Maladies H\u00e9morragiques Constitutionnelles, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6954-5460","authenticated-orcid":false,"given":"Philippe","family":"Beurrier","sequence":"additional","affiliation":[{"name":"CHU Angers, Centre de Traitement des Maladies H\u00e9morragiques Constitutionnelles, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0964-0739","authenticated-orcid":false,"given":"Marc","family":"Fouassier","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-7094","authenticated-orcid":false,"given":"Antoine","family":"Babuty","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Centre de Ressources et de Comp\u00e9tences des 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Rennes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles, Rennes, France"},{"name":"Inserm, Rennes Universit\u00e9, EHESP, IRSET (Institut de recherche en sant\u00e9, environnement et travail), UMR_S 1085, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4072-839X","authenticated-orcid":false,"given":"Marc","family":"Trossa\u00ebrt","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Centre de Ressources et de Comp\u00e9tences des Maladies H\u00e9morragiques Constitutionnelles, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"issue":"22","key":"ref1","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood-2017-05-782029","article-title":"Advances in the diagnosis and treatment of von Willebrand disease","volume":"130","author":"R 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