{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:09:01Z","timestamp":1768489741589,"version":"3.49.0"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1055\/a-2780-3344","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:13:15Z","timestamp":1768435995000},"page":"e1-e6","source":"Crossref","is-referenced-by-count":0,"title":["Successful Use of Recombinant Tissue Plasminogen Activator in an Extremely Low Birth Weight Premature Infant for the Resolution of Multiple Thrombi"],"prefix":"10.1055","volume":"16","author":[{"given":"Kartik","family":"Mody","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Pediatrix\/Arizona Neonatology, Phoenix, Arizona, United States"},{"name":"Neonatal Intensive Care Unit, Banner \u2013 University Medical Center Phoenix, Phoenix, Arizona, United States"},{"name":"College of Medicine, University of Arizona College of Medicine, Phoenix, Arizona, United States"},{"name":"Department of Pediatrics, Creighton University School of Medicine, Phoenix, Arizona, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-7074","authenticated-orcid":false,"given":"Christine","family":"Wade","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Pediatrix\/Arizona Neonatology, Phoenix, Arizona, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1163-343X","authenticated-orcid":false,"given":"Becky","family":"Micetic","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Pediatrix\/Arizona Neonatology, Phoenix, Arizona, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myleanna","family":"Vernon","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Banner \u2013 University Medical Center Phoenix, Phoenix, Arizona, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7369-1460","authenticated-orcid":false,"given":"Natalie","family":"Wade","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Pediatrix\/Arizona Neonatology, Phoenix, Arizona, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1179\/027249309X12547917868961","article-title":"Neonatal thrombo-embolism: Risk factors, clinical features and outcome","volume":"29","author":"N Demirel","year":"2009","journal-title":"Ann Trop Paediatr"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jpeds.2011.03.052","article-title":"Pediatric venous and arterial noncerebral thromboembolism in Denmark: A nationwide population-based study","volume":"159","author":"R Tuckuviene","year":"2011","journal-title":"J Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1182\/asheducation-2001.1.358","article-title":"Thromboembolic disease and antithrombotic therapy in newborns","author":"M E Andrew","year":"2001","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/MBC.0b013e3283333c7c","article-title":"Neonatal and childhood right atrial thrombosis: Recognition and a risk-stratified treatment approach","volume":"21","author":"J Y Yang","year":"2010","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood.V72.5.1651.1651","article-title":"Development of the human coagulation system in the healthy premature infant","volume":"72","author":"M Andrew","year":"1988","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jpeds.2017.12.015","article-title":"Risk factors for neonatal venous and arterial thromboembolism in the neonatal intensive care unit-a case control study","volume":"195","author":"R Bhat","year":"2018","journal-title":"J Pediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.12703\/r\/10-20","article-title":"Venous thrombosis in neonates","volume":"10","author":"M D Bhatt","year":"2021","journal-title":"Fac Rev"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/s41372-020-0678-1","article-title":"Epidemiology of thrombosis in Canadian neonatal intensive care units","volume":"40","author":"W El-Naggar","year":"2020","journal-title":"J Perinatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.96.5.939","article-title":"Neonatal thrombosis: report of a prospective Canadian and international registry","volume":"96","author":"B Schmidt","year":"1995","journal-title":"Pediatrics"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/14767058.2017.1285892","article-title":"Incidences, risk factors and outcomes of neonatal thromboembolism","volume":"31","author":"N Sirachainan","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"07","key":"ref11","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1097\/MPH.0000000000001218","article-title":"Experience and prognosis of systemic neonatal thrombosis at a level III NICU","volume":"40","author":"S Unal","year":"2018","journal-title":"J Pediatr Hematol Oncol"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1203\/00006450-200006000-00013","article-title":"Outcome of pediatric thromboembolic disease: A report from the Canadian Childhood Thrombophilia Registry","volume":"47","author":"P Monagle","year":"2000","journal-title":"Pediatr Res"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1017\/S1047951119002026","article-title":"The use of alteplase in a newborn with an aortic arch thrombus during extracorporeal membrane oxygenation","volume":"29","author":"L Yang","year":"2019","journal-title":"Cardiol Young"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-3476(98)70192-1","article-title":"Successful treatment of neonatal arterial thromboses with recombinant tissue plasminogen activator","volume":"133","author":"G M Weiner","year":"1998","journal-title":"J Pediatr"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"F66","DOI":"10.1136\/fn.85.1.F66","article-title":"Early intracardiac thrombosis in preterm infants and thrombolysis with recombinant tissue type plasminogen activator","volume":"85","author":"F Ferrari","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"02","key":"ref16","first-page":"534","article-title":"Abdominal venous thrombosis in neonates and infants: Role of prothrombotic risk factors - a multicentre case-control study","volume":"111","author":"C Heller","year":"2000","journal-title":"Br J Haematol"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1148\/radiology.219.3.r01jn17645","article-title":"Does umbilical vein catheterization lead to portal venous thrombosis? Prospective US evaluation in 100 neonates","volume":"219","author":"J H Kim","year":"2001","journal-title":"Radiology"},{"issue":"06","key":"ref18","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jpeds.2006.01.051","article-title":"Portal vein thrombosis in the neonate: risk factors, course, and outcome","volume":"148","author":"I Morag","year":"2006","journal-title":"J Pediatr"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"F18","DOI":"10.1136\/fn.85.1.F18","article-title":"Treatment of neonatal thrombus formation with recombinant tissue plasminogen activator: Six years experience and review of the literature","volume":"85","author":"J Hartmann","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MBC.0000000000001134","article-title":"Use of thrombolytic agents to treat neonatal thrombosis in clinical practice","volume":"33","author":"R Leong","year":"2022","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1440-1754.2009.01572.x","article-title":"The use of recombinant tissue plasminogen activator in the management of infective intracardiac thrombi in pre-term infants with thrombocytopaenia","volume":"45","author":"B Anderson","year":"2009","journal-title":"J Paediatr Child Health"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4274\/Tjh.07641","article-title":"A neonatal thrombosis patient treated successfully with recombinant tissue plasminogen activator","volume":"30","author":"K Erdin\u00e7","year":"2013","journal-title":"Turk J Haematol"},{"issue":"01","key":"ref23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pedneo.2012.10.006","article-title":"Successful treatment of arterial thrombus in an extremely low-birth-weight preterm neonate","volume":"54","author":"P G Kay\u0131ran","year":"2013","journal-title":"Pediatr Neonatol"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1536\/ihj.21-838","article-title":"Successful treatment of saddle pulmonary thromboembolism in 23-week preterm infant","volume":"63","author":"S Kimura","year":"2022","journal-title":"Int Heart J"},{"issue":"05","key":"ref25","doi-asserted-by":"crossref","first-page":"e04236","DOI":"10.1002\/ccr3.4236","article-title":"Recombinant tissue-type plasminogen activator treatment in an extremely low birth weight infant","volume":"9","author":"T Kurimoto","year":"2021","journal-title":"Clin Case Rep"},{"issue":"04","key":"ref26","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0022-3476(00)90006-4","article-title":"Combined thrombolytic and anticoagulant therapy for venous thrombosis in children","volume":"136","author":"M J Manco-Johnson","year":"2000","journal-title":"J Pediatr"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"e28544","DOI":"10.1002\/pbc.28544","article-title":"Thrombolytic therapy in preterm infants: Fifteen-year experience","volume":"67","author":"P Grizante-Lopes","year":"2020","journal-title":"Pediatr Blood Cancer"},{"issue":"05","key":"ref28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1067\/mpd.2001.118428","article-title":"Safety and outcomes of thrombolysis with tissue plasminogen activator for treatment of intravascular thrombosis in children","volume":"139","author":"A A Gupta","year":"2001","journal-title":"J Pediatr"},{"issue":"05","key":"ref29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00043426-200305000-00006","article-title":"Low-dose tissue plasminogen activator thrombolysis in children","volume":"25","author":"M Wang","year":"2003","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1148\/radiology.174.3.174-3-993","article-title":"Plasminogen activators: Pharmacology and therapy","volume":"174","author":"R W Holden","year":"1990","journal-title":"Radiology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"506S","DOI":"10.1378\/chest.108.4_Supplement.506S","article-title":"Antithrombotic therapy in children","volume":"108","author":"A D Michelson","year":"1995","journal-title":"Chest"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1182\/blood.V97.4.858","article-title":"Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors","volume":"97","author":"U Nowak-G\u00f6ttl","year":"2001","journal-title":"Blood"},{"issue":"08","key":"ref33","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1182\/blood.V80.8.1998.1998","article-title":"Maturation of the hemostatic system during childhood","volume":"80","author":"M Andrew","year":"1992","journal-title":"Blood"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/MOP.0b013e32831ef537","article-title":"Thrombolysis for intravascular thrombosis in neonates and children","volume":"21","author":"L Raffini","year":"2009","journal-title":"Curr Opin Pediatr"},{"issue":"02","key":"ref35","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2141.2002.03674.x","article-title":"The investigation and management of neonatal haemostasis and thrombosis","volume":"119","author":"M D Williams","year":"2002","journal-title":"Br J Haematol"},{"issue":"03","key":"ref36","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/bjh.13301","article-title":"Neonatal haemostasis and the management of neonatal thrombosis","volume":"169","author":"A Will","year":"2015","journal-title":"Br J Haematol"},{"issue":"01","key":"ref37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1182\/blood-2004-11-4211","article-title":"How I treat venous thrombosis in children","volume":"107","author":"M J Manco-Johnson","year":"2006","journal-title":"Blood"},{"issue":"04","key":"ref38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1046\/j.1440-1754.2003.00139.x","article-title":"Heparin-induced thrombocytopenia in children","volume":"39","author":"F Newall","year":"2003","journal-title":"J Paediatr Child Health"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1203\/00006450-199401000-00016","article-title":"Heparin therapy in pediatric patients: a prospective cohort study","volume":"35","author":"M Andrew","year":"1994","journal-title":"Pediatr Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e737S","DOI":"10.1378\/chest.11-2308","article-title":"Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"P Monagle","year":"2012","journal-title":"Chest"},{"issue":"05","key":"ref41","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.thromres.2008.07.009","article-title":"In vivo age dependency of unfractionated heparin in infants and children","volume":"123","author":"F Newall","year":"2009","journal-title":"Thromb Res"}],"container-title":["American Journal of Perinatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2780-3344.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:13:20Z","timestamp":1768436000000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2780-3344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":41,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,1,14]]},"published-print":{"date-parts":[[2026,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2780-3344","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2157-6998","2157-7005"],"issn-type":[{"value":"2157-6998","type":"print"},{"value":"2157-7005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}