{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:18:26Z","timestamp":1787786306417,"version":"build-2784847793"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Imaging during pregnancy presents unique challenges. Computed tomography (CT) is generally avoided due to fetal radiation exposure, and magnetic resonance imaging (MRI) may be limited by concerns regarding gadolinium-based contrast agents. As a result, ultrasound (US) remains the primary imaging tool during pregnancy. Contrast-enhanced ultrasound (CEUS) expands the diagnostic capabilities of conventional US by providing real-time vascular information comparable to contrast-enhanced CT or MRI. Importantly, microbubble contrast agents used in CEUS do not cross the placenta and have shown no fetal harm in clinical studies. Nevertheless, CEUS remains an off-label technique during pregnancy, underscoring the need for a comprehensive review of the available literature to assess its safety and clinical applications during pregnancy.<\/jats:p>\n                  <jats:p>This review summarizes the current evidence up to 2025 on the use of CEUS in pregnancy and highlights its clinical value with respect to evaluating acute and chronic maternal conditions \u2013 including oncologic, vascular, infectious, inflammatory, and other organ-specific pathologies \u2013 illustrated through representative case examples. Clinical studies, case reports, and international guidelines were analyzed with a focus on safety and diagnostic performance.<\/jats:p>\n                  <jats:p>Although still off-label, CEUS demonstrates an excellent safety profile and high diagnostic utility when clinically indicated in pregnancy. No maternal, fetal, or neonatal adverse effects have been reported, and no placental transfer of microbubbles has been demonstrated. CEUS enables high-resolution assessment of abdominal organs, vascular pathologies, and inflammatory or infectious changes, reducing the need for ionizing or gadolinium-based imaging. It represents a safe, effective, and radiation-free diagnostic alternative when conventional imaging is limited.<\/jats:p>","DOI":"10.1055\/a-2784-9759","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:10:46Z","timestamp":1770768646000},"page":"1165-1173","source":"Crossref","is-referenced-by-count":2,"title":["Contrast-Enhanced Ultrasound (CEUS) in Pregnancy: A Comprehensive Review of Clinical Applications"],"prefix":"10.1055","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4785-1849","authenticated-orcid":false,"given":"Kaltra","family":"Begaj","sequence":"additional","affiliation":[{"name":"LMU Munich, BY, Germany","place":["Munich"],"department":["Department of Radiology"]},{"name":"Martha-Maria Hospital Munich, Germany","place":["Munich"],"department":["Clinic for General, Visceral and Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Georg","family":"Sperr","sequence":"additional","affiliation":[{"name":"LMU Munich, BY, Germany","place":["Munich"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk Andre","family":"Clevert","sequence":"additional","affiliation":[{"name":"LMU Munich, BY, Germany","place":["Munich"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1097\/AOG.0b013e318180a505","article-title":"Guidelines for Computed Tomography and Magnetic Resonance Imaging Use During Pregnancy and Lactation","volume":"112","author":"MM Chen","year":"2008","journal-title":"Obstetrics & Gynecology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e210","DOI":"10.1097\/AOG.0000000000002355","article-title":"Guidelines for Diagnostic Imaging During Pregnancy and 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Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2784-9759.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:49:11Z","timestamp":1787784551000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2784-9759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,10]]},"references-count":41,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2026,8,26]]},"published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2784-9759","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,10]]}}}