{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:16:42Z","timestamp":1769779002918,"version":"3.49.0"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2023A1515010924"],"award-info":[{"award-number":["2023A1515010924"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2024A1515012652"],"award-info":[{"award-number":["2024A1515012652"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2025A1515010465"],"award-info":[{"award-number":["2025A1515010465"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82270237"],"award-info":[{"award-number":["82270237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82470231"],"award-info":[{"award-number":["82470231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Projects in Guangzhou","award":["20241A011068"],"award-info":[{"award-number":["20241A011068"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["2024A03J0079"],"award-info":[{"award-number":["2024A03J0079"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["2024A03J0375"],"award-info":[{"award-number":["2024A03J0375"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["2025A03J3367"],"award-info":[{"award-number":["2025A03J3367"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["2025A03J3369"],"award-info":[{"award-number":["2025A03J3369"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["2025A03J3453"],"award-info":[{"award-number":["2025A03J3453"]}]},{"name":"Key Medical Disciplines and Specialties Program of Guangzhou","award":["2025-2027"],"award-info":[{"award-number":["2025-2027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anti-CD36 isoantibodies can induce platelet transfusion refractoriness and fetal neonatal immune thrombocytopenia. However, the mechanism of platelet clearance mediated by these antibodies (Abs) in such disorders remains unknown.<\/jats:p>\n                  <jats:p>We analyzed platelet clearance caused by mouse and human CD36 monoclonal Abs GZ1 IgG1 and IgG2 subclasses in vitro and in vivo.<\/jats:p>\n                  <jats:p>Platelet clearance was evaluated in vitro by platelet phagocytosis assays and in vivo by monoclonal Ab GZ1 administration to C57BL\/6J mice. Platelet activation, apoptosis, and desialylation were analyzed by flow cytometry.<\/jats:p>\n                  <jats:p>Both anti-CD36 Abs subclasses caused lower platelet clearance than anti-\u03b1IIb\u03b23 owing to the Fc\u03b3R occupancy of monocytes by anti-CD36 Abs. This reaction could lead to mild thrombocytopenia, compared with the severe thrombocytopenia induced by anti-\u03b1IIb\u03b23 platelet-specific Abs. IgG subclass-mediated platelet clearance was inhibited by anti-Fc\u03b3R Abs and intravenous immunoglobulin (IVIG). The human IgG2 Ab subclass caused lower platelet clearance than IgG1. IgG1- and IgG2-mediated platelet phagocytosis was inhibited by anti-Fc\u03b3RI and anti-Fc\u03b3RII, respectively. Unlike IgG1, the IgG2 Ab subclass induced platelet activation, apoptosis, and desialylation and platelet clearance by endothelial cells via Fc-independent pathway.<\/jats:p>\n                  <jats:p>IgG1 and IgG2 subclasses of anti-CD36 Abs triggered platelet clearance primarily via the Fc-dependent pathway. The IgG2 Ab subclass, however, additionally induced platelet clearance via the Fc-independent pathway. These results indicate that the anti-CD36 Ab IgG subclass influences platelet clearance efficiency and may therefore determine the severity of immune thrombocytopenia caused by anti-CD36 antibodies.<\/jats:p>","DOI":"10.1055\/a-2787-0045","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:54:34Z","timestamp":1769730874000},"source":"Crossref","is-referenced-by-count":0,"title":["Fc-dependent and -independent Platelet Clearance Caused by Anti-CD36 IgG1 and IgG2 Subclasses"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1263-7810","authenticated-orcid":false,"given":"Hui","family":"Ren","sequence":"first","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalin","family":"Luo","sequence":"first","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhang","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Xia","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ye","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiansen","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaori","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengxue","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaqin","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"The Key Medical Laboratory of Guangzhou, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sentot","family":"Santoso","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"Institute for Clinical Immunology, Transfusion Medicine and Hemostasis, Justus-Liebig-University Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongshui","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion and Hematology, Guangzhou Blood Center, Guangzhou Medical University, Guangzhou, China"},{"name":"Department of Institute of Blood Transfusion and Hematology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China"},{"name":"Department of Transfusion Medicine, School of Medicine, the Second Affiliated Hospital of South China University of Technology, Guangzhou, China"},{"name":"Center of Guangdong Precision Blood Transfusion Engineering Technology Research, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"e20211314","DOI":"10.1084\/jem.20211314","article-title":"CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate","volume":"219","author":"Y Chen","year":"2022","journal-title":"J Exp Med"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1182\/blood.V83.2.392.392","article-title":"Platelet glycoprotein IV (CD36) 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