{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:26:24Z","timestamp":1791779184236,"version":"4.3.4"},"reference-count":62,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza \u2013 University of Rome","doi-asserted-by":"crossref","award":["AR22419077BB6154"],"award-info":[{"award-number":["AR22419077BB6154"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:p>To conduct an updated systematic review of the current evidence on the implementation of the \u2018Atrial fibrillation Better Care\u2019 (ABC) pathway for the comprehensive and holistic management of patients with Atrial Fibrillation (AF).<\/jats:p>\n                  <jats:p>We performed a systematic review and meta-analysis, searching MEDLINE and EMBASE for studies reporting the prevalence of ABC-adherent management in patients with AF and its association with clinical outcomes (all-cause death, cardiovascular death, stroke, stroke\/thromboembolism (TE), and major bleeding). Random-effects models were used to pool results from individual studies; subgroup analyses and meta-regressions were also conducted.<\/jats:p>\n                  <jats:p>Overall, 22 studies were included (including 2 randomised trials), with &gt;380,000 AF patients. Adherence to the ABC pathway was 23.9% (95%CI: 17.5%-31.7%), with substantial between-study heterogeneity (I2: 99.8%). Adherence was higher in European cohorts (37.9%, 95%CI: 27.8%-49.2%) and increased with advancing age. ABC pathway adherence was associated with a lower risk of all-cause death (Odds Ratio [OR]: 0.49, 95%CI: 0.41-0.58, I\u00b2: 97.1%), cardiovascular death (OR: 0.46, 95%CI: 0.36-0.59, I\u00b2: 96.4%), stroke (OR: 0.65, 95%CI: 0.51-0.82, I\u00b2: 93.5%), stroke\/TE (OR: 0.53, 95%CI: 0.42-0.66, I\u00b2: 91.1%) and major bleeding (OR: 0.81, 95%CI: 0.69-0.94, I\u00b2: 89.2%). The effect of the ABC pathway was consistent in clinical trials versus real-world studies, but influenced by study-level characteristics, including geographical location, mean age, prevalence of comorbidities, and the inclusion of estimates adjusted for potential confounders.<\/jats:p>\n                  <jats:p>Adherence to the ABC pathway remains suboptimal in patients with AF, but is associated with substantial beneficial effects on prognosis. Our data support widespread implementation of the ABC pathway for managing patients with AF.<\/jats:p>","DOI":"10.1055\/a-2787-0186","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:04:52Z","timestamp":1768608292000},"source":"Crossref","is-referenced-by-count":9,"title":["The \u2018Atrial Fibrillation Better Care\u2019 Pathway for Integrated Care of Atrial Fibrillation: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3788-8942","authenticated-orcid":false,"given":"Giulio Francesco","family":"Romiti","sequence":"additional","affiliation":[{"name":"Department of Wellbeing, Health and Environmental Sustainability, Sapienza \u2013 University of Rome, Rome, Italy"},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Corica","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom"},{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2895-6234","authenticated-orcid":false,"given":"Tommaso","family":"Bucci","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-6241","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Rivera-Caravaca","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom"},{"name":"Faculty of Nursing, University of Murcia, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB-Pascual Parrilla), CIBERCV, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB-Pascual Parrilla), CIBERCV, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9215-9796","authenticated-orcid":false,"given":"Lars","family":"Frost","sequence":"additional","affiliation":[{"name":"Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"},{"name":"Department of Cardiology, Regional Hospital Central Jutland, Silkeborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheorghe-Andrei","family":"Dan","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine, Academy of Romanian Scientists, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6285-6902","authenticated-orcid":false,"given":"Tatjana S.","family":"Potpara","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Belgrade, Belgrade, Serbia"},{"name":"Intensive Arrhythmia Care, Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Tokmakova","sequence":"additional","affiliation":[{"name":"Division of Cardiology, First Department of Internal Diseases, Medical University of Plovdiv, Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo Pietro","family":"Maggioni","sequence":"additional","affiliation":[{"name":"ANMCO Research Centre, Heart Care Foundation, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2787-0271","authenticated-orcid":false,"given":"S\u00f8ren Paaske","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-9378","authenticated-orcid":false,"given":"Deirdre A.","family":"Lane","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom"},{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom"},{"name":"Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom"},{"name":"Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark"},{"name":"Department of Cardiology, Lipidology and Internal Medicine with Intensive Coronary Care Unit, Medical University of Bialystok, Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Proietti","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy"},{"name":"Division of Cardiogeriatric Subacute Care, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"AF-COMET Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"100386","DOI":"10.1016\/j.lanepe.2022.100386","article-title":"Temporal trends and patterns in atrial fibrillation incidence: A population-based study of 3\u00b74 million individuals","volume":"17","author":"J Wu","year":"2022","journal-title":"Lancet Reg Health Eur"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12916-024-03373-4","article-title":"Patterns of comorbidities in patients with atrial fibrillation and impact on management and long-term prognosis: An analysis from the Prospective Global GLORIA-AF Registry","volume":"22","author":"G F Romiti","year":"2024","journal-title":"BMC Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"100596","DOI":"10.1016\/j.lanepe.2023.100596","article-title":"Time trends in atrial fibrillation-related stroke during 2001-2020 in Sweden: A nationwide, observational study","volume":"28","author":"M Ding","year":"2023","journal-title":"Lancet Reg Health Eur"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jacep.2024.10.029","article-title":"Temporal trends of ischemic stroke risk in patients with incident atrial fibrillation before anticoagulation","volume":"11","author":"K Teppo","year":"2025","journal-title":"JACC Clin Electrophysiol"},{"issue":"42","key":"ref5","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1093\/eurheartj\/ehad571","article-title":"Temporal trends of cause-specific mortality after diagnosis of atrial fibrillation","volume":"44","author":"J Wu","year":"2023","journal-title":"Eur Heart J"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.4070\/kcj.2018.0339","article-title":"2018 Korean guideline of atrial fibrillation management","volume":"48","author":"B Joung","year":"2018","journal-title":"Korean Circ J"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-0041-1739411","article-title":"2021 focused update consensus guidelines of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation: Executive summary","volume":"122","author":"T F Chao","year":"2022","journal-title":"Thromb Haemost"},{"issue":"36","key":"ref8","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"I C Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1055\/a-2325-5923","article-title":"2024 Chinese expert consensus guidelines on the diagnosis and treatment of atrial fibrillation in the elderly, endorsed by Geriatric Society of Chinese Medical Association (cardiovascular group) and Chinese Society of Geriatric Health Medicine (cardiovascular branch): Executive summary","volume":"124","author":"Y Wang","year":"2024","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jacc.2023.08.017","article-title":"2023 ACC\/AHA\/ACCP\/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"83","author":"J A Joglar","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrcardio.2017.153","article-title":"The ABC pathway: An integrated approach to improve AF management","volume":"14","author":"G YH Lip","year":"2017","journal-title":"Nat Rev Cardiol"},{"issue":"07","key":"ref12","doi-asserted-by":"crossref","first-page":"e024319","DOI":"10.1161\/JAHA.121.024319","article-title":"Effects of the Atrial Fibrillation Better Care pathway on outcomes among clinically complex Chinese patients with atrial fibrillation with multimorbidity and polypharmacy: A report from the ChiOTEAF registry","volume":"11","author":"A Kotalczyk","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/a-2559-9994","article-title":"Latent class analysis for the identification of phenotypes associated with increased risk in atrial fibrillation patients: The COOL-AF registry","volume":"126","author":"R Krittayaphong","year":"2026","journal-title":"Thromb Haemost"},{"issue":"13","key":"ref14","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.jacc.2020.01.052","article-title":"Mobile Health technology to improve care for patients with atrial fibrillation","volume":"75","author":"Y Guo","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/s41591-025-03511-2","article-title":"Telemedicine-based integrated management of atrial fibrillation in village clinics: A cluster randomized trial","volume":"31","author":"M Chu","year":"2025","journal-title":"Nat Med"},{"issue":"03","key":"ref16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1055\/a-1515-9630","article-title":"Adherence to the \u201catrial fibrillation Better Care\u201d pathway in patients with atrial fibrillation: Impact on clinical outcomes-A systematic review and meta-analysis of 285,000 patients","volume":"122","author":"G F Romiti","year":"2022","journal-title":"Thromb Haemost"},{"issue":"71","key":"ref17","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"M J Page","year":"2021","journal-title":"BMJ"},{"issue":"29","key":"ref20","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1002\/sim.4040","article-title":"Random effects meta-analysis of event outcome in the framework of the generalized linear mixed model with applications in sparse data","volume":"29","author":"T Stijnen","year":"2010","journal-title":"Stat Med"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/eb-2013-101699","article-title":"How to assess publication bias: Funnel plot, trim-and-fill method and selection models","volume":"17","author":"D Mavridis","year":"2014","journal-title":"Evid Based Ment Health"},{"issue":"04","key":"ref22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: A practical tutorial","volume":"22","author":"S Balduzzi","year":"2019","journal-title":"Evid Based Ment Health"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"W Viechtbauer","year":"2010","journal-title":"J Stat Softw"},{"key":"ref24","first-page":"101621","article-title":"Evaluation of the ABC pathway in patients with atrial fibrillation: A machine learning cluster analysis","volume":"57","author":"J Wang","year":"2025","journal-title":"Int J Cardiol Heart Vasc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"100507","DOI":"10.1016\/j.lansea.2024.100507","article-title":"Phenotypes of South Asian patients with atrial fibrillation and holistic integrated care management: Cluster analysis of data from KERALA-AF Registry","volume":"31","author":"Y Chen","year":"2024","journal-title":"Lancet Reg Health Southeast Asia"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"afae021","DOI":"10.1093\/ageing\/afae021","article-title":"Adherence to the Atrial fibrillation Better Care pathway and the risk of adverse health outcomes in older care home residents with atrial fibrillation: A retrospective data linkage study 2003-18","volume":"53","author":"L A Ritchie","year":"2024","journal-title":"Age Ageing"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.hrtlng.2024.03.002","article-title":"Adherence to the atrial fibrillation better care pathway and its associated factors among rural patients with atrial fibrillation in China: A cross-sectional study","volume":"66","author":"X Zhang","year":"2024","journal-title":"Heart Lung"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jacasi.2023.04.008","article-title":"Integrated care for atrial fibrillation using the ABC pathway in the prospective APHRS-AF registry","volume":"3","author":"T Bucci","year":"2023","journal-title":"JACC Asia"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"e028463","DOI":"10.1161\/JAHA.122.028463","article-title":"Impact of achieving blood pressure targets and high time in therapeutic range on clinical outcomes in patients with atrial fibrillation adherent to the Atrial Fibrillation Better Care pathway: A report from the COOL-AF registry","volume":"12","author":"R Krittayaphong","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2147\/PPA.S417384","article-title":"Adherence to Atrial Fibrillation Better Care (ABC) pathway management of Chinese community elderly patients with atrial fibrillation: A cross-sectional study","volume":"17","author":"X Zhang","year":"2023","journal-title":"Patient Prefer Adherence"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"856222","DOI":"10.3389\/fcvm.2022.856222","article-title":"Impact of integrated care management on clinical outcomes in atrial fibrillation patients: A report from the FANTASIIA registry","volume":"9","author":"M A Esteve-Pastor","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jacasi.2022.01.007","article-title":"Atrial fibrillation Better Care pathway adherent care improves outcomes in Chinese patients with Atrial fibrillation","volume":"2","author":"Y Guo","year":"2022","journal-title":"JACC Asia"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/europace\/euac082","article-title":"Evaluation of the atrial fibrillation better care pathway in the ENGAGE AF-TIMI 48 trial","volume":"24","author":"S M Patel","year":"2022","journal-title":"Europace"},{"issue":"02","key":"ref34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11606-022-07567-5","article-title":"The Atrial fibrillation Better Care (ABC) pathway and clinical outcomes in patients with atrial fibrillation: The prospective Murcia AF project phase II cohort","volume":"38","author":"J M Rivera-Caravaca","year":"2023","journal-title":"J Gen Intern Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"101757","DOI":"10.1016\/j.eclinm.2022.101757","article-title":"Adherence to the Atrial Fibrillation Better Care (ABC) pathway and the risk of major outcomes in patients with atrial fibrillation: A post-hoc analysis from the prospective GLORIA-AF Registry","volume":"55","author":"G F Romiti","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"06","key":"ref36","doi-asserted-by":"crossref","first-page":"e13498","DOI":"10.1111\/eci.13498","article-title":"Integrated care and outcomes in patients with atrial fibrillation and comorbidities","volume":"51","author":"M Proietti","year":"2021","journal-title":"Eur J Clin Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"762245","DOI":"10.3389\/fcvm.2021.762245","article-title":"Integrated care of atrial fibrillation using the ABC (atrial fibrillation Better Care) pathway improves clinical outcomes in Chinese population: An analysis from the Chinese Atrial Fibrillation registry","volume":"8","author":"Y F Wang","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"05","key":"ref38","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.3390\/jcm9051286","article-title":"Compliance of Atrial fibrillation treatment with the Atrial fibrillation Better Care (ABC) pathway improves the clinical outcomes in the Middle East population: A report from the Gulf survey of Atrial fibrillation events (SAFE) registry","volume":"9","author":"J Gumprecht","year":"2020","journal-title":"J Clin Med"},{"issue":"03","key":"ref39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.20452\/pamw.15146","article-title":"Adherence to the ABC (Atrial fibrillation Better Care) pathway in the Balkan region: The BALKAN-AF survey","volume":"130","author":"M Kozie\u0142","year":"2020","journal-title":"Pol Arch Intern Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejim.2020.12.011","article-title":"The Atrial fibrillation Better Care (ABC) pathway and cardiac complications in atrial fibrillation: a potential sex-based difference. The ATHERO-AF study","volume":"85","author":"D Pastori","year":"2021","journal-title":"Eur J Intern Med"},{"issue":"02","key":"ref41","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/europace\/euaa274","article-title":"Relation of outcomes to ABC (Atrial Fibrillation Better Care) pathway adherent care in European patients with atrial fibrillation: an analysis from the ESC-EHRA EORP Atrial Fibrillation General Long-Term (AFGen LT) Registry","volume":"23","author":"M Proietti","year":"2021","journal-title":"Europace"},{"issue":"04","key":"ref42","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/joa3.12364","article-title":"Application of the simple atrial fibrillation better care pathway for integrated care management in frail patients with atrial fibrillation: A nationwide cohort study","volume":"36","author":"P S Yang","year":"2020","journal-title":"J Arrhythm"},{"issue":"11","key":"ref43","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.amjmed.2018.06.012","article-title":"Improved outcomes by integrated care of anticoagulated patients with atrial fibrillation using the simple ABC (Atrial fibrillation Better Care) pathway","volume":"131","author":"M Proietti","year":"2018","journal-title":"Am J Med"},{"issue":"01","key":"ref44","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS guideline for the Diagnosis and Management of Atrial Fibrillation: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"J A Joglar","year":"2024","journal-title":"Circulation"},{"issue":"04","key":"ref45","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/eurjcn\/zvad093","article-title":"Understanding for whom, under what conditions, and how an integrated approach to atrial fibrillation service delivery works: A realist review","volume":"23","author":"A Pearsons","year":"2024","journal-title":"Eur J Cardiovasc Nurs"},{"issue":"08","key":"ref46","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1016\/j.hrthm.2025.02.013","article-title":"Racial differences and similarities in atrial fibrillation epidemiology and risk factors in UK Biobank and Korean NHIS-HEALS cohort studies","volume":"22","author":"M H Kim","year":"2025","journal-title":"Heart Rhythm"},{"issue":"09","key":"ref47","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1055\/a-2278-8769","article-title":"Racial differences in ischemic and hemorrhagic stroke: An ecological epidemiological study","volume":"124","author":"D S Kang","year":"2024","journal-title":"Thromb Haemost"},{"issue":"09","key":"ref48","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1055\/a-2269-1123","article-title":"Racial differences in bleeding risk: An ecological epidemiological study comparing Korea and United Kingdom subjects","volume":"124","author":"D S Kang","year":"2024","journal-title":"Thromb Haemost"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"102039","DOI":"10.1016\/j.eclinm.2023.102039","article-title":"Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: A post-hoc analysis from the GLORIA-AF Registry","volume":"63","author":"G F Romiti","year":"2023","journal-title":"EClinicalMedicine"},{"issue":"08","key":"ref50","doi-asserted-by":"crossref","first-page":"afac192","DOI":"10.1093\/ageing\/afac192","article-title":"Epidemiology and impact of frailty in patients with atrial fibrillation in Europe","volume":"51","author":"M Proietti","year":"2022","journal-title":"Age Ageing"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"101652","DOI":"10.1016\/j.arr.2022.101652","article-title":"Frailty prevalence and impact on outcomes in patients with atrial fibrillation: A systematic review and meta-analysis of 1,187,000 patients","volume":"79","author":"M Proietti","year":"2022","journal-title":"Ageing Res Rev"},{"issue":"00","key":"ref52","first-page":"S1547","article-title":"Association of comorbidity patterns with outcomes and relation with the ABC pathway effectiveness in European patients with atrial fibrillation","volume":"0","author":"G F Romiti","year":"2025","journal-title":"Heart Rhythm"},{"issue":"07","key":"ref53","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/ehjqcco\/qcaf014","article-title":"Patterns of comorbidities, clinical course, and impact of the ABC Pathway for Integrated Care in patients with atrial fibrillation: A report from the prospective Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) Registry","volume":"11","author":"M Mantovani","year":"2025","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"e2140071","DOI":"10.1001\/jamanetworkopen.2021.40071","article-title":"mAF-App II Trial investigators. The effects of implementing a Mobile Health-Technology supported pathway on Atrial Fibrillation-related adverse events among patients with multimorbidity: The mAFA-II randomized clinical trial: The mAFA-II randomized clinical trial","volume":"4","author":"Y Yao","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"06","key":"ref55","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1007\/s11606-024-09037-6","article-title":"Efficacy of the ABC pathway for integrated care across phenotypes of patients with Atrial fibrillation: A latent-class analysis report from the mAFA-II clinical trial","volume":"40","author":"B Corica","year":"2025","journal-title":"J Gen Intern Med"},{"issue":"11","key":"ref56","doi-asserted-by":"crossref","first-page":"afac245","DOI":"10.1093\/ageing\/afac245","article-title":"Mobile health technology integrated care in older atrial fibrillation patients: a subgroup analysis of the mAFA-II randomised clinical trial","volume":"51","author":"Y Guo","year":"2022","journal-title":"Age Ageing"},{"issue":"03","key":"ref57","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jamda.2024.01.011","article-title":"Predictors and outcomes of oral anticoagulant deprescribing in geriatric inpatients with atrial fibrillation: A retrospective multicenter cohort study","volume":"25","author":"E Brunetti","year":"2024","journal-title":"J Am Med Dir Assoc"},{"issue":"08","key":"ref58","doi-asserted-by":"crossref","first-page":"e010642","DOI":"10.1161\/CIRCOUTCOMES.123.010642","article-title":"Trajectories of frailty and clinical outcomes in older adults with atrial fibrillation: Insights from the Shizuoka Kokuho database","volume":"17","author":"R Nakamaru","year":"2024","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"02","key":"ref59","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1055\/s-0043-1770724","article-title":"Effect of oral anticoagulants in atrial fibrillation patients with polypharmacy: A meta-analysis","volume":"125","author":"Y Zheng","year":"2025","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1055\/s-0043-1769735","article-title":"The impact of polypharmacy on the effectiveness and safety of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation","volume":"124","author":"M Grymonprez","year":"2024","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref61","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/ehjqcco\/qcad055","article-title":"Estimating the impact of implementing an integrated care management approach with Atrial fibrillation Better Care (ABC) pathway for patients with atrial fibrillation in England from 2020 to 2040","volume":"10","author":"E M Camacho","year":"2024","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"31","key":"ref62","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1093\/eurheartj\/ehac265","article-title":"A multinational European network to implement integrated care in elderly multimorbid atrial fibrillation patients: The AFFIRMO Consortium","volume":"43","author":"S P Johnsen","year":"2022","journal-title":"Eur Heart J"},{"issue":"03","key":"ref63","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/a-2508-5708","article-title":"A European-multicenter network for the implementation of artificial intelligence to manage complexity and comorbidities of atrial fibrillation patients: The ARISTOTELES consortium","volume":"125","author":"G Boriani","year":"2025","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref64","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/a-2438-5671","article-title":"TARGET Consortium. TARGET: A major European project aiming to advance the personalised management of atrial fibrillation-related stroke via the development of health virtual twins technology and artificial intelligence","volume":"125","author":"S Ortega-Martorell","year":"2025","journal-title":"Thromb Haemost"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2787-0186.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:00:46Z","timestamp":1777881646000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2787-0186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":62,"URL":"https:\/\/doi.org\/10.1055\/a-2787-0186","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1,16]]},"published":{"date-parts":[[2026,1,16]]}}}