{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:02:44Z","timestamp":1785214964394,"version":"3.55.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Respiratory support use in neonatal intensive care units (NICUs) varies worldwide, influenced by clinical practices, resources, and patient populations. Whether high-altitude independently affects the duration of respiratory support in preterm infants remains unclear. This study aimed to determine whether altitude is independently associated with the duration of respiratory support in preterm infants \u226432 weeks' gestational age (GA) admitted to Latin American NICUs.<\/jats:p>\n                  <jats:p>We performed a multicenter, observational cohort study by secondary analysis of prospectively collected data from the EpicLatino Network, a registry of NICUs across Latin America (2015\u20132022). Infants \u226432 weeks who received invasive or non-invasive respiratory support were included; supplemental oxygen delivered via low-flow nasal cannula or oxygen hood was not considered respiratory support, and those with missing outcome data were excluded. The primary outcome was total duration of respiratory support, measured as total days of support until discontinuation, discharge, transfer, or truncation by death. Altitude was classified as high (\u22652,000 m) or low (&lt;2,000 m). Multivariable analyses were adjusted for neonatal, maternal, and unit characteristics.<\/jats:p>\n                  <jats:p>A total of 4,428 infants were included; 2,723 (61.5%) in low-altitude NICUs and 1,705 (38.5%) in high-altitude NICUs. Overall, 81.4% discontinued respiratory support and 18.6% died. Mortality was 19.1% in low-altitude and 17.9% in high-altitude NICUs. Median duration of support was 8 days (interquartile range [IQR]: 5\u201314) overall, with 9 days (IQR: 4\u201327) in low-altitude and 7 days (IQR: 3\u201317) in high-altitude NICUs. High-altitude centers showed shorter respiratory support in unadjusted analyses. After adjustment for neonatal, maternal, and unit factors, altitude was not independently associated with support duration.<\/jats:p>\n                  <jats:p>After adjustment for neonatal, maternal, and unit factors, altitude was not independently associated with the duration of respiratory support. Importantly, high altitude was never associated with worse outcomes.<\/jats:p>","DOI":"10.1055\/a-2788-2071","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:31:24Z","timestamp":1768437084000},"page":"1493-1501","source":"Crossref","is-referenced-by-count":0,"title":["High Altitude and Duration of Respiratory Support in Preterm Infants: A Multicenter, Observational Cohort from Latin America"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-3268","authenticated-orcid":false,"given":"Angela B.","family":"Hoyos","sequence":"additional","affiliation":[{"name":"Division of Neonatology, El Bosque University, Bogota, DC, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-5032","authenticated-orcid":false,"given":"Pablo","family":"Vasquez-Hoyos","sequence":"additional","affiliation":[{"name":"Hospital de San Jos\u00e9 Bogot\u00e1, DC, Colombia"},{"name":"Universidad Nacional and Universidad Ciencias de la Salud, Bogot\u00e1, DC, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-2565","authenticated-orcid":false,"given":"Horacio","family":"Osiovich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, BC Women's Hospital, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-0385","authenticated-orcid":false,"given":"Carlos A.","family":"Fajardo","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-7747","authenticated-orcid":false,"given":"Ariel A.","family":"Salas","sequence":"additional","affiliation":[{"name":"Helping Babies Feed Program and NEC\/Short Bowel Prevention Program, Mother's Milk Bank of Alabama, Birmingham, Alabama, United States"},{"name":"Continuing Care Nursery, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3930-8745","authenticated-orcid":false,"given":"Carolina","family":"Villegas","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Central Hospital Dr. Ignacio Morones Prieto, San Luis Potos\u00ed, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-7279","authenticated-orcid":false,"given":"Fernando","family":"Aguinaga","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Metropolitano Hospital, Quito, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7530-0713","authenticated-orcid":false,"given":"Martha","family":"Baez","sequence":"additional","affiliation":[{"name":"Division of Neonatology, El Bosque University, Clinica del Country, Bogota, DC, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-1955","authenticated-orcid":false,"given":"Maria Ines","family":"Martinini","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Nuestra Se\u00f1ora de las Mercedes Maternity, Tucuman, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4103\/0972-5229.164800","article-title":"Neonatal mechanical ventilation: Indications and outcome","volume":"19","author":"Q Iqbal","year":"2015","journal-title":"Indian J Crit Care Med"},{"issue":"01","key":"ref2","first-page":"13","article-title":"\u201cCurrent concepts of mechanical ventilation in neonates\u201d - 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