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Translational studies have explored neuroactive steroids targeting extrasynaptic GABAA receptors, T-type calcium channel blockers, SK-channel enhancers, and AMPA antagonists, with variable clinical efficacy. These findings highlight the biological heterogeneity of ET and the challenge of aligning molecular targets with meaningful clinical outcomes. Future progress will require precision-based pharmacotherapy, integrating circuit-specific biomarkers, mechanistic patient stratification, and real-world measures of tremor impact to transform the landscape of ET treatment.<\/jats:p>","DOI":"10.1055\/a-2789-0097","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:50:13Z","timestamp":1770421813000},"page":"532-543","source":"Crossref","is-referenced-by-count":0,"title":["Essential Tremor Pharmacotherapy: Bench to Bedside"],"prefix":"10.1055","volume":"46","author":[{"given":"TinaMarie","family":"Lieu","sequence":"additional","affiliation":[{"name":"Sage Therapeutics, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rich","family":"Able","sequence":"additional","affiliation":[{"name":"Praxis Precision Medicines, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Smith","sequence":"additional","affiliation":[{"name":"Initiative for Columbia Ataxia and Tremor, Columbia University, New York, New York, United States"},{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Han","family":"Kuo","sequence":"additional","affiliation":[{"name":"Initiative for Columbia Ataxia and Tremor, Columbia University, New York, New York, United States"},{"name":"Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5334\/tohm.632","article-title":"How common is essential tremor? 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Babij","year":"2013","journal-title":"Brain"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/mds.26490","article-title":"Purkinje cell loss in essential tremor: Random sampling quantification and nearest neighbor analysis","volume":"31","author":"M Choe","year":"2016","journal-title":"Mov Disord"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1093\/brain\/awu281","article-title":"Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum","volume":"137","author":"C Y Lin","year":"2014","journal-title":"Brain"},{"issue":"22","key":"ref15","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1212\/WNL.0000000000001636","article-title":"Climbing fiber synaptic changes correlate with clinical features in essential tremor","volume":"84","author":"R J 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Neurosci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/B978-0-444-53630-3.00008-7","article-title":"Neurosteroids: endogenous role in the human brain and therapeutic potentials","volume":"186","author":"D S Reddy","year":"2010","journal-title":"Prog Brain Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/bs.irn.2022.02.003","article-title":"Is essential tremor a degenerative disorder or an electric disorder? 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potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4\/6beta3delta GABAA receptors","volume":"103","author":"H J Hanchar","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"02","key":"ref55","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s13311-023-01342-y","article-title":"Cerebellar \u03b16GABAA receptors as a therapeutic target for essential tremor: proof-of-concept study with ethanol and pyrazoloquinolinones","volume":"20","author":"Y H Huang","year":"2023","journal-title":"Neurotherapeutics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5334\/tohm.760","article-title":"Alcohol and ganaxolone suppress tremor via extra-synaptic GABAA receptors in the harmaline model of essential tremor","volume":"13","author":"A Handforth","year":"2023","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"key":"ref57","first-page":"1206","article-title":"Essential tremor","volume":"2015","author":"T A Zesiewicz","year":"2015","journal-title":"Clin Evid"},{"issue":"01","key":"ref58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.300.1.2","article-title":"A new benzodiazepine pharmacology","volume":"300","author":"H M\u00f6hler","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"issue":"19","key":"ref59","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1212\/WNL.0b013e318236f0fd","article-title":"Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology","volume":"77","author":"T A Zesiewicz","year":"2011","journal-title":"Neurology"},{"issue":"02","key":"ref60","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1212\/WNL.34.2.221","article-title":"Effect of alcohol on tremors: comparison with propranolol","volume":"34","author":"W C Koller","year":"1984","journal-title":"Neurology"},{"issue":"03","key":"ref61","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/mds.20331","article-title":"Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications","volume":"20","author":"F C Martin","year":"2005","journal-title":"Mov Disord"},{"issue":"02","key":"ref62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1212\/WNL.23.2.145","article-title":"Primidone, diphenylhydantoin and phenobarbital. 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Mitchell","year":"2003","journal-title":"Neuron"},{"issue":"05","key":"ref69","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.tins.2004.03.005","article-title":"Tonically active GABA A receptors: modulating gain and maintaining the tone","volume":"27","author":"A Semyanov","year":"2004","journal-title":"Trends Neurosci"},{"issue":"04","key":"ref70","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0896-6273(02)00593-7","article-title":"Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex","volume":"33","author":"M Hamann","year":"2002","journal-title":"Neuron"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"546","DOI":"10.5334\/tohm.407","article-title":"Suppression of harmaline tremor by activation of an extrasynaptic GABAA receptor: implications for essential tremor","volume":"8","author":"A Handforth","year":"2018","journal-title":"Tremor Other Hyperkinet Mov (N 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calcium channel isoforms to neuronal firing","volume":"4","author":"S M Cain","year":"2010","journal-title":"Channels (Austin)"},{"issue":"03","key":"ref79","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.neuroscience.2009.04.045","article-title":"Inferior olive oscillation as the temporal basis for motricity and oscillatory reset as the basis for motor error correction","volume":"162","author":"R R Llin\u00e1s","year":"2009","journal-title":"Neuroscience"},{"issue":"03","key":"ref80","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuron.2009.03.023","article-title":"Encoding of oscillations by axonal bursts in inferior olive neurons","volume":"62","author":"A Mathy","year":"2009","journal-title":"Neuron"},{"issue":"06","key":"ref81","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1523\/JNEUROSCI.19-06-01895.1999","article-title":"Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels","volume":"19","author":"E M Talley","year":"1999","journal-title":"J Neurosci"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1113\/jphysiol.2009.184705","article-title":"Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P\/Q- and T-type calcium channels: a study in mutant mice","volume":"588","author":"S Choi","year":"2010","journal-title":"J Physiol"},{"issue":"07","key":"ref83","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3390\/genes14071380","article-title":"A novel KCNN2 variant in a family with essential tremor plus: clinical characteristics and in silico analysis","volume":"14","author":"M d'Apolito","year":"2023","journal-title":"Genes (Basel)"},{"issue":"01","key":"ref84","doi-asserted-by":"crossref","first-page":"11","DOI":"10.31887\/DCNS.2013.15.1\/jhenley","article-title":"AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging","volume":"15","author":"J M Henley","year":"2013","journal-title":"Dialogues Clin Neurosci"},{"issue":"04","key":"ref85","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.celrep.2016.06.053","article-title":"Ionic basis for membrane potential resonance in neurons of the inferior olive","volume":"16","author":"Y Matsumoto-Makidono","year":"2016","journal-title":"Cell Rep"},{"issue":"07","key":"ref86","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00424-020-02429-7","article-title":"Neuronal Cav3 channelopathies: recent progress and perspectives","volume":"472","author":"P Lory","year":"2020","journal-title":"Pflugers Arch"},{"issue":"23","key":"ref87","doi-asserted-by":"crossref","first-page":"10731","DOI":"10.1073\/pnas.1002995107","article-title":"Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive","volume":"107","author":"Y G Park","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref88","first-page":"172","article-title":"The potential roles of T-type Ca2+ channels in motor coordination","volume":"7","author":"Y G Park","year":"2013","journal-title":"Front Neural Circuits"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fncel.2016.00192","article-title":"Heterogeneous expression of T-type Ca(2+) channels defines different neuronal populations in the inferior olive of the mouse","volume":"10","author":"P Bazzigaluppi","year":"2016","journal-title":"Front Cell Neurosci"},{"issue":"50","key":"ref90","doi-asserted-by":"crossref","first-page":"20302","DOI":"10.1073\/pnas.1311686110","article-title":"T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning","volume":"110","author":"R Ly","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"06","key":"ref91","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/mds.28969","article-title":"Translational pharmacology of PRAX-944, a novel T-type calcium channel blocker in development for the treatment of essential tremor","volume":"37","author":"L Scott","year":"2022","journal-title":"Mov Disord"},{"issue":"08","key":"ref92","doi-asserted-by":"crossref","first-page":"e0220512","DOI":"10.1371\/journal.pone.0220512","article-title":"Whole genome sequencing and rare variant analysis in essential tremor families","volume":"14","author":"Z Odgerel","year":"2019","journal-title":"PLoS One"},{"issue":"06","key":"ref93","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ana.410250610","article-title":"Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons","volume":"25","author":"D A Coulter","year":"1989","journal-title":"Ann Neurol"},{"issue":"02","key":"ref94","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1527-3458.2007.00009.x","article-title":"Ethosuximide: from bench to bedside","volume":"13","author":"M Z G\u00f6ren","year":"2007","journal-title":"CNS Drug Rev"},{"issue":"09","key":"ref95","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJMoa0902014","article-title":"Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy","volume":"362","author":"T A Glauser","year":"2010","journal-title":"N Engl J Med"},{"issue":"06","key":"ref96","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuropharm.2010.05.012","article-title":"T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor","volume":"59","author":"A Handforth","year":"2010","journal-title":"Neuropharmacology"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"378","DOI":"10.5334\/tohm.306","article-title":"Ethosuximide for essential tremor: an open-label trial","volume":"6","author":"A Gironell","year":"2016","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"issue":"01","key":"ref98","doi-asserted-by":"crossref","first-page":"e200210","DOI":"10.1212\/CPJ.0000000000200210","article-title":"Zonisamide: a comprehensive, updated review for the clinician","volume":"14","author":"B E Gidal","year":"2024","journal-title":"Neurol Clin Pract"},{"issue":"02","key":"ref99","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1059-1311(96)80104-X","article-title":"Mechanisms of T-type calcium channel blockade by zonisamide","volume":"5","author":"M Kito","year":"1996","journal-title":"Seizure"},{"issue":"06","key":"ref100","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/WNF.0b013e318074dd4f","article-title":"Zonisamide for essential tremor","volume":"30","author":"W G Ondo","year":"2007","journal-title":"Clin Neuropharmacol"},{"issue":"02","key":"ref101","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/mds.21282","article-title":"A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor","volume":"22","author":"T A Zesiewicz","year":"2007","journal-title":"Mov Disord"},{"issue":"04","key":"ref102","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1172\/JCI83621","article-title":"Dose-escalation study of octanoic acid in patients with essential tremor","volume":"126","author":"B Voller","year":"2016","journal-title":"J Clin Invest"},{"issue":"10","key":"ref103","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1212\/WNL.0b013e3182840c4f","article-title":"Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study","volume":"80","author":"D Haubenberger","year":"2013","journal-title":"Neurology"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3389\/fneur.2019.00597","article-title":"A phase 2, randomized, double-blind, placebo-controlled trial of CX-8998, a selective modulator of the T-type calcium channel in inadequately treated moderate to severe essential tremor: T-CALM study design and methodology for efficacy endpoint and digital biomarker selection","volume":"10","author":"S Papapetropoulos","year":"2019","journal-title":"Front Neurol"},{"issue":"08","key":"ref106","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/mds.28584","article-title":"A phase 2 proof-of-concept, randomized, placebo-controlled trial of CX-8998 in essential tremor","volume":"36","author":"S Papapetropoulos","year":"2021","journal-title":"Mov Disord"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/bs.irn.2022.02.008","article-title":"Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor","volume":"163","author":"A Wagle Shukla","year":"2022","journal-title":"Int Rev Neurobiol"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-physiol-020911-153336","article-title":"Small-conductance Ca2+-activated K+ channels: form and function","volume":"74","author":"J P Adelman","year":"2012","journal-title":"Annu Rev Physiol"},{"issue":"20","key":"ref118","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1007\/s00018-008-8216-x","article-title":"Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain","volume":"65","author":"P Pedarzani","year":"2008","journal-title":"Cell Mol Life Sci"},{"issue":"23","key":"ref119","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1523\/JNEUROSCI.22-23-10163.2002","article-title":"Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding","volume":"22","author":"R W Stackman","year":"2002","journal-title":"J Neurosci"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1113\/jphysiol.2003.049072","article-title":"Small conductance Ca2+-activated K+ channels and calmodulin","volume":"554","author":"J Maylie","year":"2004","journal-title":"J Physiol"},{"issue":"5282","key":"ref121","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.273.5282.1709","article-title":"Small-conductance, calcium-activated potassium channels from mammalian brain","volume":"273","author":"M K\u00f6hler","year":"1996","journal-title":"Science"},{"issue":"01","key":"ref122","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuron.2012.05.025","article-title":"SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells","volume":"75","author":"G Ohtsuki","year":"2012","journal-title":"Neuron"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainres.2017.09.012","article-title":"Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel","volume":"1676","author":"T Kuramoto","year":"2017","journal-title":"Brain Res"},{"issue":"05","key":"ref124","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/sj.bjp.0707281","article-title":"Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels","volume":"151","author":"C Hougaard","year":"2007","journal-title":"Br J Pharmacol"},{"issue":"10","key":"ref125","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.chembiol.2012.07.013","article-title":"Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2","volume":"19","author":"A W Kasumu","year":"2012","journal-title":"Chem Biol"},{"issue":"06","key":"ref126","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1152\/jn.00913.2015","article-title":"In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model","volume":"115","author":"P A Egorova","year":"2016","journal-title":"J Neurophysiol"},{"issue":"03","key":"ref127","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.pneurobio.2010.03.002","article-title":"Small conductance calcium-activated potassium channels: from structure to function","volume":"91","author":"K L Weatherall","year":"2010","journal-title":"Prog Neurobiol"},{"issue":"04","key":"ref130","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1152\/jn.00477.2001","article-title":"GABAergic and glutamatergic modulation of spontaneous and motor-cortex-evoked complex spike activity","volume":"87","author":"E J Lang","year":"2002","journal-title":"J Neurophysiol"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.neuro.25.112701.142758","article-title":"AMPA receptor trafficking and synaptic plasticity","volume":"25","author":"R Malinow","year":"2002","journal-title":"Annu Rev Neurosci"},{"issue":"49","key":"ref132","doi-asserted-by":"crossref","first-page":"17846","DOI":"10.1073\/pnas.0508910102","article-title":"A mechanism underlying AMPA receptor trafficking during cerebellar long-term potentiation","volume":"102","author":"W Kakegawa","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnsyn.2016.00035","article-title":"Modulation, plasticity and pathophysiology of the parallel fiber-Purkinje cell synapse","volume":"8","author":"E Hoxha","year":"2016","journal-title":"Front Synaptic Neurosci"},{"issue":"02","key":"ref134","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuron.2018.10.018","article-title":"The AMPA receptor code of synaptic plasticity","volume":"100","author":"G H Diering","year":"2018","journal-title":"Neuron"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.irn.2022.02.009","article-title":"Is the inferior olive central to essential tremor? Yes","volume":"163","author":"E J Lang","year":"2022","journal-title":"Int Rev Neurobiol"},{"issue":"05","key":"ref136","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0968-0896(01)00431-X","article-title":"9-carboxymethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one-2-carbocylic acid (RPR117824): selective anticonvulsive and neuroprotective AMPA antagonist","volume":"10","author":"S Mignani","year":"2002","journal-title":"Bioorg Med Chem"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2009.05.031","article-title":"Pharmacological characterization of harmaline-induced tremor activity in mice","volume":"616","author":"N E Paterson","year":"2009","journal-title":"Eur J Pharmacol"},{"issue":"01","key":"ref138","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1124\/jpet.113.204735","article-title":"Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574","volume":"347","author":"C L Shaffer","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"issue":"13","key":"ref139","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.3390\/ijms26136450","article-title":"Positive AMPA and kainate receptor modulators and their therapeutic potential in CNS diseases: a comprehensive review","volume":"26","author":"A Vialko","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"04","key":"ref141","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/mdc3.12927","article-title":"A pilot double-blind randomized trial of perampanel for essential tremor","volume":"7","author":"A Handforth","year":"2020","journal-title":"Mov Disord Clin Pract"},{"key":"ref142","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.parkreldis.2018.10.010","article-title":"Perampanel, a new hope for Essential tremor: an open label trial","volume":"60","author":"A Gironell","year":"2019","journal-title":"Parkinsonism Relat Disord"}],"container-title":["Seminars in Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2789-0097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:52:06Z","timestamp":1789599126000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2789-0097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":127,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,9,16]]},"published-print":{"date-parts":[[2026,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2789-0097","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0271-8235","1098-9021"],"issn-type":[{"value":"0271-8235","type":"print"},{"value":"1098-9021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]}}}