{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:58:34Z","timestamp":1781218714526,"version":"3.54.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vertebral hemangiomas are typically benign and asymptomatic, but a small subset, known as aggressive vertebral hemangiomas, may present with neurological deficits due to extraosseous extension and spinal cord compression. These cases require timely diagnosis and a multidisciplinary management approach.<\/jats:p>\n                  <jats:p>A 42-year-old man presented with acute-onset severe mid-back pain for 2 months. Neurological examination revealed exaggerated reflexes without motor or sensory deficits. Magnetic resonance imaging showed expansile lesions at T7, T9, and T10, with additional angiomatous lesions at T3 and T4. T7 and T10 lesions caused spinal cord compression. Preoperative embolization of T7 and T10 was performed using polidocanol. The patient subsequently underwent vertebroplasty at T7, T9, and T10 levels, pedicle screw fixation from T4 to T11, posterior decompression at T6 to T7 and T9 to T10. Intraoperative biopsies revealed a cavernous hemangioma at T7 and a capillary hemangioma at T9. No malignancy was found<\/jats:p>\n                  <jats:p>Postoperative recovery was uneventful, with early mobilization and significant functional improvement. At 2-year follow-up, the patient had no pain or neurological symptoms, and radiographs showed stable fixation with no recurrence.<\/jats:p>\n                  <jats:p>Aggressive vertebral hemangiomas, though rare, should be considered in patients with progressive neurological symptoms. Early diagnosis, embolization, surgical decompression, and stabilization can yield excellent outcomes.<\/jats:p>","DOI":"10.1055\/a-2790-5191","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:07:59Z","timestamp":1768867679000},"page":"294-300","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Presentation of Concurrent Typical, Atypical, and Aggressive Thoracic Vertebral Hemangiomas: Insights into Histological Variability and Multidisciplinary Management"],"prefix":"10.1055","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-0111","authenticated-orcid":false,"given":"J.S.R.G.","family":"Saran","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"M.","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravikumar","family":"TV","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshith","family":"Gopinath","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan Kumar","family":"M.","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, M.S. 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Health"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1080\/09638288.2020.1804626","article-title":"The diagnostic value of Red Flags in thoracolumbar pain: a systematic review","volume":"44","author":"F Maselli","year":"2022","journal-title":"Disabil Rehabil"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.radcr.2018.04.016","article-title":"A unique case of benign intracranial hemangioma mimicking malignant transformation","volume":"13","author":"N A Almaghrabi","year":"2018","journal-title":"Radiol Case Rep"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1067\/mjd.2003.200","article-title":"Hemangiomas of infancy","volume":"48","author":"A L Bruckner","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.12659\/AJCR.889388","article-title":"Cavernous hemangioma of the parietal bone","volume":"14","author":"I B Atc\u0131","year":"2013","journal-title":"Am J Case Rep"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1148\/56.2.256","article-title":"Hemangioma of bone","volume":"56","author":"S F Oosthuizen","year":"1951","journal-title":"Radiology"},{"issue":"10","key":"ref8","first-page":"7","article-title":"Aggressive hemangioma of the thoracic spine","volume":"5","author":"W B Schrock","year":"2011","journal-title":"J Radiol Case Rep"},{"issue":"S 01","key":"ref9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00586-016-4765-0","article-title":"A case report of spondylectomy with circumference reconstruction for aggressive vertebral hemangioma covering the whole cervical spine (C4) with progressive spinal disorder","volume":"26","author":"M Nakahara","year":"2017","journal-title":"Eur Spine J"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.spinee.2013.07.450","article-title":"Diagnosis and treatment of vertebral hemangiomas with neurologic deficit: a report of 29 cases and literature review","volume":"14","author":"L Jiang","year":"2014","journal-title":"Spine J"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41394-023-00577-3","article-title":"Aggressive thoracic vertebral hemangioma: case report and literature review","volume":"9","author":"A Kuo","year":"2023","journal-title":"Spinal Cord Ser Cases"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.32677\/IJCH.2015.v02.i01.013","article-title":"Aggressive vertebral haemangioma in early adolescent age group: atypical presentation with computed tomography and magnetic resonance imaging appearance","volume":"2","author":"B B Sharma","year":"2015","journal-title":"Indian J Child Health (Bhopal)"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s00586-005-0885-7","article-title":"Multilevel vertebral hemangiomas: two episodes of spinal cord compression at separate levels 10 years apart","volume":"14","author":"O Karaeminogullari","year":"2005","journal-title":"Eur Spine J"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4103\/0976-9668.160030","article-title":"Rare case of multiple aggressive vertebral hemangiomas","volume":"6","author":"P S Mahajan","year":"2015","journal-title":"J Nat Sci Biol Med"},{"issue":"06","key":"ref15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0090-3019(98)00007-X","article-title":"Vertebral hemangiomas: diagnosis, management, natural history and clinicopathological correlates in 86 patients","volume":"50","author":"A I Pastushyn","year":"1998","journal-title":"Surg 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Radiologic spectrum of Paget disease of bone and its complications with pathologic correlation","volume":"22","author":"S E Smith","year":"2002","journal-title":"Radiographics"},{"issue":"04","key":"ref19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF00596582","article-title":"Primary vertebral and spinal epidural non-Hodgkin's lymphoma with spinal cord compression","volume":"38","author":"M Boukobza","year":"1996","journal-title":"Neuroradiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.amsu.2017.12.001","article-title":"Surgical treatment of aggressive vertebral hemangioma causing progressive paraparesis","volume":"25","author":"M Dobran","year":"2017","journal-title":"Ann Med Surg (Lond)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"100968","DOI":"10.1016\/j.inat.2020.100968","article-title":"Percutaneous vertebroplasty for the treatment of symptomatic vertebral hemangioma with long-term follow-up","volume":"23","author":"A K Gupta","year":"2021","journal-title":"Interdiscip Neurosurg"},{"issue":"09","key":"ref22","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.spinee.2023.04.002","article-title":"Surgical management of symptomatic vertebral hemangiomas: a single institution experience and literature review","volume":"23","author":"N Teferi","year":"2023","journal-title":"Spine J"},{"issue":"01","key":"ref23","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1186\/s12885-019-6072-8","article-title":"Pseudomyogenic hemangioendothelioma of bone treated with denosumab: a case report","volume":"19","author":"S Otani","year":"2019","journal-title":"BMC Cancer"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3109\/02688697.2014.997668","article-title":"Mixed capillary-cavernous extramedullary intradural hemangioma of the spinal cord mimicking meningioma: case report","volume":"29","author":"A Alobaid","year":"2015","journal-title":"Br J Neurosurg"},{"issue":"09","key":"ref25","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/BRS.0000000000000840","article-title":"Spinal hemangiomas: results of surgical management for local recurrence and mortality in a multicenter study","volume":"40","author":"C L Goldstein","year":"2015","journal-title":"Spine"},{"key":"ref26","first-page":"724364","article-title":"Total en bloc spondylectomy for locally aggressive vertebral hemangioma causing neurological deficits","volume":"2015","author":"R Ogawa","year":"2015","journal-title":"Case Rep Orthop"},{"issue":"02","key":"ref27","first-page":"528","article-title":"Chiropractic management of symptomatic pedicle hemangioma: a case report","volume":"17","author":"E C-P Chu","year":"2022","journal-title":"Maedica (Buchar)"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0360-3016(85)90162-2","article-title":"Radiotherapy in the treatment of vertebral hemangiomas","volume":"11","author":"S L Faria","year":"1985","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"05","key":"ref29","first-page":"296","article-title":"[Radiotherapy of vertebral hemangioma with neurologic complications]","volume":"35","author":"J M Pavlovitch","year":"1989","journal-title":"Neurochirurgie"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/0973-1482.65248","article-title":"Symptomatic vertebral hemangioma: treatment with radiotherapy","volume":"6","author":"R K Aich","year":"2010","journal-title":"J Cancer Res Ther"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"548","DOI":"10.22603\/ssrr.2024-0023","article-title":"Sclerotherapy for aggressive vertebral hemangioma with severe bone destruction: a 5-year analysis","volume":"8","author":"C Takeda","year":"2024","journal-title":"Spine Surg Relat Res"},{"issue":"01","key":"ref32","first-page":"43","article-title":"Percutaneous cement vertebroplasty in the treatment of symptomatic vertebral hemangiomas","volume":"15","author":"J Hao","year":"2012","journal-title":"Pain Physician"},{"issue":"09","key":"ref33","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/sj.sc.3100438","article-title":"Symptomatic vertebral haemangioma: endovascular treatment of 12 patients","volume":"35","author":"P N Jayakumar","year":"1997","journal-title":"Spinal Cord"},{"issue":"05","key":"ref34","first-page":"289","article-title":"[Embolization of vertebral hemangioma. Technic-indications-results]","volume":"35","author":"L Picard","year":"1989","journal-title":"Neurochirurgie"},{"issue":"02","key":"ref35","first-page":"e55114","article-title":"Rapid recuperation after surgical intervention and rehabilitation in a patient with spinal haemangioma: a case report","volume":"16","author":"R Gabada","year":"2024","journal-title":"Cureus"},{"issue":"02","key":"ref36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1148\/radiology.214.2.r00fe46341","article-title":"Symptomatic vertebral hemangiomas: treatment by means of direct intralesional injection of ethanol","volume":"214","author":"J L Doppman","year":"2000","journal-title":"Radiology"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2790-5191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:38:09Z","timestamp":1781217489000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2790-5191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":36,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2026,6,11]]},"published-print":{"date-parts":[[2026,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2790-5191","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1,19]]},"published":{"date-parts":[[2026,1,19]]}}}