{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:08:26Z","timestamp":1780441706991,"version":"3.54.1"},"reference-count":6,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Das Nationale Register Prostatakarzinom (ProNAT) der Deutschen Uro-Onkologen (d-uo) wurde 2022 initiiert, um die sektoren\u00fcbergreifende Versorgung von Patienten mit Prostatakarzinom in Deutschland realit\u00e4tsnah abzubilden. Aufbauend auf der VERSUS-Studie werden detaillierte Verlaufsdaten zur Qualit\u00e4t, Leitlinienadh\u00e4renz und Therapie erfasst.<\/jats:p>\n                  <jats:p>ProNAT ist ein nicht-interventionelles, prospektives, multizentrisches Register (DRKS00030737, Ethikvotum Berlin 2018). Eingeschlossen werden Patienten mit histologisch gesichertem Prostatakarzinom aus 55 d-uo-Praxen. Erfasst werden demografische und klinische Basisdaten, Tumorstadium, Therapieformen, Komorbidit\u00e4ten sowie psychoonkologische Betreuung.<\/jats:p>\n                  <jats:p>Bis August 2025 wurden 3417 Patienten dokumentiert (auswertbar n = 3052; medianes Alter 69 Jahre). 91,1% befanden sich in gutem Allgemeinzustand (ECOG 0\u20131). H\u00e4ufige Komorbidit\u00e4ten waren arterielle Hypertonie (30,6%), Diabetes mellitus (8,2%) und kardiovaskul\u00e4re Erkrankungen (9,1%). Bei 6,7% lagen prim\u00e4r Metastasen vor; 77,6% hatten T1\u2013T2-Tumoren. Eine mpMRT vor Biopsie erfolgte bei 36,6%. Kurative Operationen wurden zu 87,7% roboterassistiert durchgef\u00fchrt. Bei Gleason 3 + 3-Tumoren erhielten 35,1% eine aktive \u00dcberwachung, 37,8% eine Operation. Psychoonkologische Betreuung wurde nur bei 18,2% dokumentiert.<\/jats:p>\n                  <jats:p>ProNAT liefert erstmals umfassende Real-World-Daten zur ambulanten Versorgung von Prostatakarzinompatienten in Deutschland. Die Ergebnisse zeigen Fortschritte in der Leitlinienadh\u00e4renz, aber Optimierungsbedarf bei psychoonkologischer Betreuung und multidisziplin\u00e4rer Therapieplanung. Mit weiteren Patienteneinschl\u00fcssen werden k\u00fcnftig detaillierte Analysen zu Therapiesequenzen und Versorgungsqualit\u00e4t m\u00f6glich.<\/jats:p>","DOI":"10.1055\/a-2794-3373","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:52:18Z","timestamp":1772603538000},"page":"260-265","source":"Crossref","is-referenced-by-count":1,"title":["Aktuelle Daten aus dem Nationalen Register Prostatakarzinom (ProNAT) von d-uo"],"prefix":"10.1055","volume":"57","author":[{"given":"Frank","family":"K\u00f6nig","sequence":"first","affiliation":[{"name":"Urologische Gemeinschaftspraxis ATURO, Germany","place":["Berlin"]},{"name":"Vorstand d-uo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Johannsen","sequence":"first","affiliation":[{"name":"Vorstand d-uo"},{"name":"Facharztpraxis Urologie Johannsen & Laux, Germany","place":["Berlin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Klier","sequence":"additional","affiliation":[{"name":"Vorstand d-uo"},{"name":"Urologische Partnerschaft K\u00f6ln (UPK), Germany","place":["K\u00f6ln"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Eichenauer","sequence":"additional","affiliation":[{"name":"Vorstand d-uo"},{"name":"Urologikum MVZ, Germany","place":["Hamburg"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sch\u00f6nfelder","sequence":"additional","affiliation":[{"name":"Vorstand d-uo"},{"name":"Urologie, Dres. Sch\u00f6nfelder & Stra\u00dfer, Germany","place":["Hamburg"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Urologische Gemeinschaftspraxis ATURO, Germany","place":["Berlin"]},{"name":"Vorstand d-uo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Hempel","sequence":"additional","affiliation":[{"name":"Vorstand d-uo"},{"name":"SMGF Forschungsgesellschaft, Germany","place":["Berlin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Doehn","sequence":"additional","affiliation":[{"name":"Vorstand d-uo"},{"name":"Klinik f\u00fcr Urologie, UKSH Campus L\u00fcbeck"},{"name":"Urologikum L\u00fcbeck, Germany","place":["L\u00fcbeck"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1055\/s-0044-101694","article-title":"Versorgungsforschung in der Uroonkologie \u2013 Von der Last zur Lust auf Daten","volume":"49","author":"F K\u00f6nig","year":"2018","journal-title":"Akt Urologie"},{"key":"ref3","first-page":"57","article-title":"IQUO 2.0 \u2013 ein Zwischenstand","volume":"1","year":"2018","journal-title":"J Onkologie"},{"key":"ref4","first-page":"62","article-title":"IQUO 2.0 \u2013 Dokumentation = Neustart gelungen","volume":"7","author":"F K\u00f6nig","year":"2018","journal-title":"J Onkologie"},{"key":"ref6","first-page":"70","article-title":"Krebsregistermeldung \u00fcber d-uo: spart Zeit und ist dazu auch noch wissenschaftlich und wirtschaftlich interessant","volume":"1","author":"R Sch\u00f6nfelder","year":"2021","journal-title":"J Onkologie"},{"key":"ref7","first-page":"70","article-title":"ProNAT zur Erfassung und Verbesserung der Sektoren-\u00fcbergreifenden Versorgungsqualit\u00e4t ab sofort offen!","volume":"10","author":"F K\u00f6nig","year":"2022","journal-title":"J Onkologie"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1055\/a-2065-8990","article-title":"2023 Nationale Register Urothelkarzinom (UroNAT) und Prostatakarzinom (ProNAT) von d-uo","volume":"54","author":"M Johannsen","year":"2023","journal-title":"Akt Urol"}],"container-title":["Aktuelle Urologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2794-3373.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:33:21Z","timestamp":1780439601000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2794-3373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":6,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,6,2]]},"published-print":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2794-3373","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0001-7868","1438-8820"],"issn-type":[{"value":"0001-7868","type":"print"},{"value":"1438-8820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]}}}