{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:17:05Z","timestamp":1782947825789,"version":"3.54.5"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Im Zuge des Blauzungenkrankheitsausbruchs mit dem Serotyp 3 des Blauzungenvirus\n(BTV-3) in Deutschland 2024\/25 wurden in einer s\u00e4chsischen Fleischrinderherde\nbei 6 neugeborenen K\u00e4lbern neurologische Auff\u00e4lligkeiten direkt post natum\nfestgestellt. Ziel dieser Fallstudie ist die Beschreibung der Klinik der 6\nK\u00e4lber, die pathologisch-anatomischen und lichtmikroskopischen Befunde eines\ndieser Tiere sowie die virologischen Untersuchungsergebnisse des Bestandes. Die\nbetroffenen K\u00e4lber zeigten Orientierungslosigkeit, fehlende Reflexe und\nSaugschw\u00e4che. Bei dem sezierten Kalb konnte ein ausgepr\u00e4gter\nbilateral-symmetrischer Verlust der Gro\u00dfhirnrinde mit fl\u00fcssigkeitsgef\u00fcllten\nHohlr\u00e4umen im Neuroparenchym und dilatierten Seitenventrikeln im Sinne einer\nHydranenzephalie festgestellt werden. Histologisch zeigten sich eine kortikale\nHypo- und Dysplasie, zystische Defekte, Mikro- und Astrogliose sowie\ndystrophische Verkalkungen. Bei 3 von 3 untersuchten K\u00e4lbern war mittels RT-PCR\nim Blut BTV-3-RNA nachweisbar und sie zeigten hohe Antik\u00f6rpertiter, ebenso wie\nderen M\u00fctter und der Gro\u00dfteil des Bestandes. Die Evaluierung der\nepidemiologischen Situation des Bestandes deutet auf eine m\u00f6gliche intrauterine\nBTV-3-Infektion etwa um den 120. Tr\u00e4chtigkeitstag hin. Der Nachweis einer\nHydranenzephalie im vorliegenden Fall unterst\u00fctzt die Grundregel, dass eine\ngenaue morphologische Charakterisierung der L\u00e4sionen wesentlich zur Abgrenzung\ngegen\u00fcber anderen, insbesondere viralen Ursachen von ZNS-Missbildungen beim Kalb\nbeitragen kann.<\/jats:p>","DOI":"10.1055\/a-2794-3457","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T23:06:02Z","timestamp":1775775962000},"page":"199-208","source":"Crossref","is-referenced-by-count":0,"title":["Hydranenzephalie bei einem neugeborenen Kalb nach intrauteriner\nBTV-3-Infektion in einer s\u00e4chsischen Fleischrinderherde"],"prefix":"10.1055","volume":"54","author":[{"given":"Magdalena","family":"Schollmeyer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Veterin\u00e4r-Pathologie, Veterin\u00e4rmedizinische Fakult\u00e4t,\nUniversit\u00e4t Leipzig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Freick","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Agrar- und Ern\u00e4hrungswissenschaften,\nNaturwissenschaftliche Fakult\u00e4t III Martin-Luther-Universit\u00e4t Halle-Wittenberg,\nHalle (Saale)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Schwarzer","sequence":"additional","affiliation":[{"name":"Landesuntersuchungsanstalt f\u00fcr das Gesundheits- und Veterin\u00e4rwesen\nSachsen, Standort Chemnitz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Schink\u00f6the","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Veterin\u00e4r-Pathologie, Veterin\u00e4rmedizinische Fakult\u00e4t,\nUniversit\u00e4t Leipzig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virusdiagnostik, Friedrich-Loeffler-Institut,\nGreifswald-Insel Riems"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"P\u00fctzschel","sequence":"additional","affiliation":[{"name":"Rindergesundheitsdienst, S\u00e4chsische Tierseuchenkasse,\nDresden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Veterin\u00e4r-Pathologie, Veterin\u00e4rmedizinische Fakult\u00e4t,\nUniversit\u00e4t Leipzig"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"ref3","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.2460\/javma.1995.206.09.1322","article-title":"Pathogenesis of bluetongue virus infection of cattle","volume":"206","author":"S M Barratt-Boyes","year":"1995","journal-title":"javma"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"106493","DOI":"10.1016\/j.prevetmed.2025.106493","article-title":"The impact of bluetongue serotype 3 on cattle mortality, abortions and premature\nbirths in the Netherlands in the first year of the epidemic","volume":"239","author":"KMJ A van den Brink","year":"2025","journal-title":"Prev Vet Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e4533","DOI":"10.1002\/vetr.4533","article-title":"Bluetongue virus serotype 3 in ruminants in the Netherlands: Clinical signs,\nseroprevalence and pathological findings","volume":"195","author":"KMJ A van den Brink","year":"2024","journal-title":"Vet Rec"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13028-015-0145-8","article-title":"Virus-induced congenital malformations in cattle","volume":"57","author":"J S Agerholm","year":"2015","journal-title":"Acta Vet Scand"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.prevetmed.2008.06.004","article-title":"Field observations during the bluetongue serotype 8 epidemic in 2006. 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