{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:18:37Z","timestamp":1787872717444,"version":"build-2784847793"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"DOI":"10.13039\/100009045","name":"Uniwersytet Jagiello\u0144ski Collegium Medicum","doi-asserted-by":"crossref","award":["K\/ZDS\/002936"],"award-info":[{"award-number":["K\/ZDS\/002936"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Left ventricular thrombus (LVT) commonly complicates ST-segment elevation myocardial infarction (MI), and up to 30% of LVT may persist despite anticoagulation. Data linking post-MI LVT and inherited thrombophilias are sparse.<\/jats:p>\n                  <jats:p>A total of 148 consecutive MI patients with LVT at a mean age of 63.9 (6.9) years were referred for further workup. After 3 months of oral anticoagulation, screening for factor V Leiden (FVL) and prothrombin G20210A variant, protein S, protein C, and antithrombin deficiency was performed. Subjects with antiphospholipid syndrome were not eligible. Thrombus persistence was assessed after 3 and 6 months of anticoagulation.<\/jats:p>\n                  <jats:p>Inherited thrombophilias were identified in 34 (23%) patients, including 18 (52.9%) with FVL, 9 (26.5%) with prothrombin G20210A variant, 3 (8.8%) with protein C deficiency, and 4 (11.8%) with protein S deficiency. Carriers of thrombophilias were similar to non-thrombophilic subjects, except for higher fibrinogen in the former group. Inherited thrombophilias were associated with LVT persistence after 3 and 6 months post MI (25 [73.5%] vs. 50 [43.9%], p\u2009=\u20090.002 and 20 [58.8%] vs. 24 [21.1%], p\u2009&lt;\u20090.001, respectively). Inherited thrombophilias were independently associated with an increased risk of persistent LVT 3 and 6 months post MI (OR 2.75, 95% CI 1.13\u20136.74, p\u2009=\u20090.026 and OR 4.06, 95% CI 1.57\u201310.51, p\u2009=\u20090.004, respectively).<\/jats:p>\n                  <jats:p>Our findings suggest that inherited thrombophilias may predispose to LVT persistence despite anticoagulation in MI survivors. Thrombophilia screening may help identify a subgroup likely to benefit from prolonged anticoagulation.<\/jats:p>","DOI":"10.1055\/a-2794-5001","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:48:04Z","timestamp":1770684484000},"page":"897-907","source":"Crossref","is-referenced-by-count":1,"title":["Inherited Thrombophilia as a Risk Factor for Persistent Left Ventricular Thrombus Following Acute Myocardial Infarction"],"prefix":"10.1055","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9781-1202","authenticated-orcid":false,"given":"Krystian","family":"Mr\u00f3z","sequence":"additional","affiliation":[{"name":"Clinical Department of Interventional Cardiology, St. John Paul II Hospital, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Paszek","sequence":"additional","affiliation":[{"name":"Clinical Department of Interventional Cardiology, St. John Paul II Hospital, Krakow, Poland"},{"name":"Department of Thromboembolic Disorders, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wypasek","sequence":"additional","affiliation":[{"name":"Center for Innovative Laboratory Diagnostics, St. John Paul II Hospital, Krakow, Poland"},{"name":"Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anetta","family":"Undas","sequence":"additional","affiliation":[{"name":"Department of Thromboembolic Disorders, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland"},{"name":"Krakow Center for Medical Research and Technologies, St. John Paul II Hospital, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1001\/jamacardio.2018.1086","article-title":"Left ventricular thrombus after acute myocardial infarction: screening, prevention, and treatment","volume":"3","author":"C P McCarthy","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"14","key":"ref2","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.jacc.2020.01.057","article-title":"Antithrombotic therapy for patients with left ventricular mural thrombus","volume":"75","author":"B Lattuca","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"15","key":"ref3","doi-asserted-by":"crossref","first-page":"e205","DOI":"10.1161\/CIR.0000000000001092","article-title":"Management of patients at risk for and with left ventricular thrombus: a scientific statement from the American Heart 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Haller","year":"2024","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11239-015-1316-1","article-title":"Guidance for the evaluation and treatment of hereditary and acquired thrombophilia","volume":"41","author":"S M Stevens","year":"2016","journal-title":"J Thromb Thrombolysis"},{"issue":"05","key":"ref8","first-page":"885","article-title":"Classic thrombophilic gene variants","volume":"114","author":"P M Mannucci","year":"2015","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/GIM.0b013e3181faa0f2","article-title":"Factor V Leiden thrombophilia","volume":"13","author":"J L Kujovich","year":"2011","journal-title":"Genet Med"},{"key":"ref10","first-page":"512","article-title":"Genetic characterization of antithrombin, protein C, and protein S deficiencies in Polish patients","volume":"127","author":"E Wypasek","year":"2017","journal-title":"Pol Arch Intern Med"},{"issue":"09","key":"ref11","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1055\/s-0043-1768712","article-title":"Antithrombin deficiency is associated with prothrombotic plasma fibrin clot phenotype","volume":"123","author":"J Natorska","year":"2023","journal-title":"Thromb Haemost"},{"issue":"19","key":"ref12","doi-asserted-by":"crossref","first-page":"e012877","DOI":"10.1161\/JAHA.119.012877","article-title":"Inherited thrombophilia and the risk of arterial ischemic stroke: a systematic review and meta-analysis","volume":"8","author":"T Chiasakul","year":"2019","journal-title":"J Am Heart Assoc"},{"issue":"23","key":"ref13","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1182\/blood.2023023326","article-title":"Thrombosis risk in single- and double-heterozygous carriers of factor V Leiden and prothrombin G20210A in FinnGen and the UK Biobank","volume":"143","author":"J Ryu","year":"2024","journal-title":"Blood"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jacc.2022.01.011","article-title":"Left ventricular thrombus following acute myocardial infarction: JACC State-of-the-Art Review","volume":"79","author":"A Camaj","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11897-024-00671-z","article-title":"The role of coagulation in heart failure: a literature review","volume":"21","author":"F Anjum","year":"2024","journal-title":"Curr Heart Fail Rep"},{"issue":"06","key":"ref16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0894-7317(14)80362-3","article-title":"The natural history of left ventricular spontaneous contrast","volume":"3","author":"D N Doud","year":"1990","journal-title":"J Am Soc 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the Italian Society of Hemostasis and Thrombosis (SISET)","author":"E Valeriani","year":"2025","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4244\/EIJ-D-24-00527","article-title":"Direct oral anticoagulants or warfarin in patients with left ventricular thrombus after ST-elevation myocardial infarction: a pilot trial and a prespecified meta-analysis of randomised trials","volume":"21","author":"Y Jenab","year":"2025","journal-title":"EuroIntervention"},{"issue":"06","key":"ref27","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.thromres.2015.10.019","article-title":"Thrombophilia testing patterns amongst patients with acute venous thromboembolism","volume":"136","author":"M R Meyer","year":"2015","journal-title":"Thromb Res"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00019501-200403000-00006","article-title":"Predictors of left ventricular thrombus formation in patients with dilated cardiomyopathy: role of activated protein C resistance","volume":"15","author":"A R Erbay","year":"2004","journal-title":"Coron Artery Dis"},{"issue":"04","key":"ref29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/gtmb.2010.0017","article-title":"Risk of myocardial infarction related to factor V Leiden mutation: a meta-analysis","volume":"14","author":"M Dowaidar","year":"2010","journal-title":"Genet Test Mol Biomarkers"},{"issue":"03","key":"ref30","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1160\/TH12-01-0041","article-title":"The influence of factor V Leiden and G20210A prothrombin mutation on the presence of residual vein obstruction after idiopathic deep-vein thrombosis of the lower limbs","volume":"109","author":"B Cosmi","year":"2013","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2143\/AC.59.1.2005156","article-title":"Coexistence of prothrombic risk factors and its relation to left ventricular thrombus in acute myocardial infarction","volume":"59","author":"F U\u00e7ar","year":"2004","journal-title":"Acta Cardiol"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"419","DOI":"10.33963\/KP.14804","article-title":"Inherited thrombophilia and the risk of myocardial infarction: current evidence and uncertainties","volume":"77","author":"Z Bereczky","year":"2019","journal-title":"Kardiol Pol"},{"issue":"03","key":"ref33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jtha.2023.01.002","article-title":"Dilemmas in hematology: consults in patients with arterial thrombosis","volume":"21","author":"D Swan","year":"2023","journal-title":"J Thromb Haemost"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00019501-200005000-00010","article-title":"Predictors of left ventricular thrombus formation in patients with anterior myocardial infarction: role of activated protein C resistance","volume":"11","author":"E Yetkin","year":"2000","journal-title":"Coron Artery Dis"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00380-005-0880-2","article-title":"Churg-Strauss syndrome and congenital factor Leiden thrombophilia as nontypical causes of intracardiac thrombosis","volume":"21","author":"K Mizia-Stec","year":"2006","journal-title":"Heart Vessels"},{"issue":"04","key":"ref36","first-page":"341","article-title":"Sequential thromboembolic events after primary angioplasty in a patient with acute anterior myocardial infarction","volume":"1","author":"C Aggeli","year":"2012","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"ref37","first-page":"7576801","article-title":"Large left ventricular thrombus in a patient with systemic and venous thromboembolism secondary to protein C and S deficiency","volume":"2017","author":"M Pahuja","year":"2017","journal-title":"Case Rep Cardiol"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2143\/AC.56.1.2005587","article-title":"Factor V Leiden and its relation to left ventricular thrombus in acute myocardial infarction","volume":"56","author":"S Celik","year":"2001","journal-title":"Acta Cardiol"},{"issue":"22","key":"ref39","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1182\/bloodadvances.2023010177","article-title":"American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing","volume":"7","author":"S Middeldorp","year":"2023","journal-title":"Blood Adv"},{"issue":"06","key":"ref40","first-page":"100890","article-title":"Practical guideline for major hereditary thrombophilia","volume":"6","author":"L V Tang","year":"2025","journal-title":"Innovation (Camb)"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1111\/j.1538-7836.2006.02139.x","article-title":"Family history and inherited thrombophilia","volume":"4","author":"G L van Sluis","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"09","key":"ref42","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/j.1538-7836.2004.00852.x","article-title":"Familial thrombophilia and lifetime risk of venous thrombosis","volume":"2","author":"C Y Vossen","year":"2004","journal-title":"J Thromb Haemost"},{"issue":"04","key":"ref43","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/jth.14398","article-title":"Direct oral anticoagulants in patients with venous thromboembolism and thrombophilia: a systematic review and meta-analysis","volume":"17","author":"M AT Elsebaie","year":"2019","journal-title":"J Thromb Haemost"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1016\/j.jtha.2024.08.006","article-title":"The use of direct oral anticoagulants in the secondary prevention of venous thromboembolism in patients with severe thrombophilia: communication from the ISTH SSC Subcommittee on Physiological Anticoagulants and Thrombophilia","volume":"22","author":"M Kovac","year":"2024","journal-title":"J Thromb Haemost"},{"issue":"05","key":"ref45","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1538-7836.2010.03773.x","article-title":"Prothrombin G20210A carriers the genetic mutation and a history of venous thrombosis contributes to thrombin generation independently of factor II plasma levels","volume":"8","author":"G Lavigne-Lissalde","year":"2010","journal-title":"J Thromb Haemost"},{"key":"ref46","volume-title":"Physiology, Acute Phase Reactants","author":"R Gulhar","year":"2025"},{"issue":"04","key":"ref47","doi-asserted-by":"crossref","first-page":"e13718","DOI":"10.1111\/eci.13718","article-title":"Fibrinogen \u03b2 chain and FXIII polymorphisms affect fibrin clot properties in acute pulmonary embolism","volume":"52","author":"A Klajmon","year":"2022","journal-title":"Eur J Clin Invest"},{"issue":"02","key":"ref48","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.amjmed.2023.09.021","article-title":"Secondary prevention therapies in real-world patients with myocardial infarction: eligibility based on randomized trials supporting European and American guidelines","volume":"137","author":"C Mas-Llado","year":"2024","journal-title":"Am J Med"},{"issue":"03","key":"ref49","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/jcpt.12813","article-title":"Adherence to guidelines for pharmacological treatment of young adults with myocardial infarction in Poland: Data from Polish Registry of Acute Coronary Syndromes (PL-ACS)","volume":"44","author":"A Lisowska","year":"2019","journal-title":"J Clin Pharm Ther"},{"issue":"06","key":"ref50","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jcin.2014.12.242","article-title":"Biochemical validation of patient-reported symptom onset time in patients with ST-segment elevation 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