{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:03:01Z","timestamp":1790377381285,"version":"4.1.0"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die digitale Brust-Tomosynthese (DBT) erh\u00f6ht die Sensitivit\u00e4t und Spezifit\u00e4t im Vergleich zur digitalen Mammografie (DM) in der Brustkrebs-Fr\u00fcherkennung. Potenziale k\u00fcnstlicher Intelligenz (KI) in der mammografischen Befundung einschlie\u00dflich einer Reduktion der Arbeitslast werden zunehmend berichtet.<\/jats:p>\n                  <jats:p>Darstellung der aktuellen Evidenz zur Wirksamkeit von DBT versus DM in der bev\u00f6lkerungsbezogenen Brustkrebs-Fr\u00fcherkennung und deren Unterst\u00fctzung durch KI. Narrative \u00dcbersichtsarbeit mit themengeleiteter Literatursuche vergleichender Studien von DBT und DM sowie zum KI-Einsatz in PubMed von 01\/2016 bis 09\/2025.<\/jats:p>\n                  <jats:p>In 42 internationalen Studien lag die Brustkrebsdetektionsrate mit DBT + DM (6,4\u2030) und DBT + synthetischer Mammografie (SM) (7,4\u2030) signifikant h\u00f6her als mit DM (4,7\u2030). Konkordant berichtete die gr\u00f6\u00dfte randomisierte TOSYMA-Studie eine h\u00f6here invasive Brustkrebsdetektionsrate mit DBT + SM (7,1\u2030) versus DM (4,8\u2030) bei niedrigerer falsch-positiver R\u00fcckrufrate (Erstteilnahme \u201315,6\u2030). Der positive pr\u00e4diktive Wert (PPV) des R\u00fcckrufs war \u2013 konsistent mit Metaanalysen \u2013 h\u00f6her (+4,9%), gleichzeitig stieg die Befundungszeit. Bei geringerer Anzahl von KI-Studien mit DBT als DM berichtete eine DBT-Metaanalyse eine h\u00f6here Sensitivit\u00e4t durch KI allein (89%) als durch Befunder (78 %) bei geringerer Spezifit\u00e4t der KI. DBT mit KI-unterst\u00fctzter Befundung im Vergleich zur alleinigen menschlichen Befundung steigerte die Detektionsrate in einer prospektiven Studie um +3,8\u2030 ohne relevante \u00c4nderung der R\u00fcckrufrate (+0,8%).<\/jats:p>\n                  <jats:p>DBT erh\u00f6ht in der Fr\u00fcherkennung die Brustkrebsdetektionsrate im Vergleich zur DM bei g\u00fcnstigeren Prozessparametern. KI-Befundungsstrategien k\u00f6nnen die Sensitivit\u00e4t weiter erh\u00f6hen und menschliche Arbeitszeit reduzieren. Der Einfluss von DBT und KI auf die Intervallkarzinomrate als Effektivit\u00e4tsparameter ist noch nicht belegt.<\/jats:p>","DOI":"10.1055\/a-2796-5225","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T23:48:46Z","timestamp":1772668126000},"page":"1271-1281","source":"Crossref","is-referenced-by-count":0,"title":["Digitale Brust-Tomosynthese und Befundung mit k\u00fcnstlicher Intelligenz"],"prefix":"10.1055","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-8831","authenticated-orcid":false,"given":"Stefanie","family":"Weigel","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster Faculty of Medicine, Germany","place":["M\u00fcnster"],"department":["Clinic for Radiology and Reference Center for Mammography M\u00fcnster"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Wunderlich","sequence":"additional","affiliation":[{"name":"Radiological Site, Sachsen, 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Image-guided Therapy, Austria","place":["Vienna"],"department":["Unit of General Radiology and Paediatric Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8805-2291","authenticated-orcid":false,"given":"Cornelia Lieselotte Angelika","family":"Dewald","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Lower Saxony, Germany","place":["Hannover"],"department":["Diagnostic and Interventional Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Preibsch","sequence":"additional","affiliation":[{"name":"University Hospital T\u00fcbingen, Germany","place":["T\u00fcbingen"],"department":["Diagnostic and Interventional Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-9365","authenticated-orcid":false,"given":"Stephanie","family":"Sauer","sequence":"additional","affiliation":[{"name":"University Hospital 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