{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:19:17Z","timestamp":1783466357090,"version":"3.55.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Achieving proper skin closure after total knee arthroplasty (TKA) is crucial for minimizing complications, as the surrounding skin is under significant tension during the early postoperative period. Cyanoacrylate, or skin adhesive, supplements subcuticular suture closure, providing a secure, watertight seal while lowering infection risk. This study compared wound healing, complications, and patient-reported outcomes between suture closure and suture plus adhesive. A total of 167 patients undergoing primary TKA were enrolled in a prospective single-blinded protocol change study at a single institution from August 2023 to September 2024. Patients had their wound closed with subcuticular 3\u20130 Monocryl suture (n\u2009=\u200969) or suture plus cyanoacrylate adhesive (S\u2009+\u2009C) (n\u2009=\u200998), alternating techniques every 3 months. Scar healing was assessed through photographic review at 1 month, evaluating scabbing and scar length. Wound complications, stiffness, and readmission rates were recorded. Patient satisfaction was measured at 6 months using the Patient and Observer Scar Assessment Scale (POSAS) score. Bivariate analyses evaluated differences between groups. Wound complications occurred at a similar rate between suture (11.6%) and S\u2009+\u2009C (14.3%; p\u2009=\u20090.784). Stiffness was reported in 6.6% of patients (8.7% suture vs. 5.1% S\u2009+\u2009C; p\u2009=\u20090.365). A 90-day readmission occurred in 3.6% (4.4% suture vs. 3.1% S\u2009+\u2009C; p\u2009=\u20090.692). Scar healing assessments showed 19.1% of patients had more than two scabs, with a higher frequency in S\u2009+\u2009C (24.2%) than sutures (12.5%; p\u2009=\u20090.193). The mean scar length was slightly longer in S\u2009+\u2009C (15.0 vs. 14.5\u2009cm; p\u2009=\u20090.148). No cosmetic differences were noted between groups according to the mean POSAS score (5.0\u2009\u00b1\u20094.18 sutures vs. 5.1\u2009\u00b1\u20095.57 S\u2009+\u2009C; p\u2009=\u20090.641). Both sutures and cyanoacrylate adhesive demonstrated comparable clinical and patient-reported outcomes following TKA. The cyanoacrylate adhesive group had a slightly higher rate of minor wound healing concerns. Both closure methods are viable options, and the choice of technique can be left to the surgeon.<\/jats:p>","DOI":"10.1055\/a-2796-8586","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:45:33Z","timestamp":1770421533000},"page":"497-502","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Cyanoacrylate Skin Adhesive on Outcomes Following Total Knee Arthroplasty: A Prospective Evaluation"],"prefix":"10.1055","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3828-1265","authenticated-orcid":false,"given":"Gabriel","family":"Furey","sequence":"additional","affiliation":[{"name":"Department of Research, Rothman Orthopaedic Institute, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-5341","authenticated-orcid":false,"given":"Juan D.","family":"Lizcano","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Rothman Orthopaedic Institute, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordero","family":"Mccall","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Rothman Orthopaedic Institute Center City, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Rothman Orthopaedic Institute Center City, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad A.","family":"Krueger","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Jefferson, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Purtill","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Rothman Institute Orthopaedics, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2106\/JBJS.G.01371","article-title":"Surgical treatment of early wound complications following primary total knee arthroplasty","volume":"91","author":"D D Galat","year":"2009","journal-title":"J Bone Joint Surg Am"},{"issue":"34","key":"ref2","doi-asserted-by":"crossref","first-page":"e21947","DOI":"10.1097\/MD.0000000000021947","article-title":"Clinical outcome of different skin closure in total-knee arthroplasty: running subcuticular closure vs intermittent closure: a retrospective study","volume":"99","author":"L Chen","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.arth.2011.02.029","article-title":"A comparison of wound closure techniques for total knee arthroplasty","volume":"26","author":"M D Eggers","year":"2011","journal-title":"J Arthroplasty"},{"issue":"02","key":"ref4","first-page":"340","article-title":"Wound closure after total knee replacement: comparison between staples and sutures","volume":"38","author":"M A Khan","year":"2022","journal-title":"Pak J Med Sci"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11999-015-4209-x","article-title":"The Chitranjan Ranawat Award: running subcuticular closure enables the most robust perfusion after TKA: a randomized clinical trial","volume":"474","author":"C C Wyles","year":"2016","journal-title":"Clin Orthop Relat 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Med"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/1757177414551562","article-title":"The antibacterial effect of 2-octyl cyanoacrylate (Dermabond) skin adhesive","volume":"15","author":"J L Rushbrook","year":"2014","journal-title":"J Infect Prev"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1016\/j.arth.2017.07.012","article-title":"Characterizing the diagnosis and treatment of allergic contact dermatitis to 2-octyl cyanoacrylate used for skin closure in elective orthopedic surgery","volume":"32","author":"B P Chalmers","year":"2017","journal-title":"J Arthroplasty"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2147\/TCRM.S260007","article-title":"A prospective, randomized and controlled study on tissue adhesive for skin incision in total knee arthroplasty","volume":"16","author":"X Kong","year":"2020","journal-title":"Ther Clin Risk Manag"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/iwj.13044","article-title":"Systematic review of the use of cyanoacrylate glue in addition to standard wound closure in the prevention of surgical site infection","volume":"16","author":"M Machin","year":"2019","journal-title":"Int Wound J"},{"issue":"09","key":"ref13","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1016\/j.arth.2021.04.033","article-title":"2-Octyl cyanoacrylate topical adhesive as an alternative to subcuticular suture for skin closure after total knee arthroplasty: a randomized controlled trial in the same patient","volume":"36","author":"K Y Choi","year":"2021","journal-title":"J Arthroplasty"},{"issue":"08","key":"ref14","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.arth.2017.02.042","article-title":"MONOCRYL and DERMABOND vs staples in total hip arthroplasty performed through a lateral skin incision: a randomized controlled trial using a patient-centered assessment tool","volume":"32","author":"R A Glennie","year":"2017","journal-title":"J Arthroplasty"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"e23058","DOI":"10.1016\/j.heliyon.2023.e23058","article-title":"Does cyanoacrylate have the best postoperative outcomes after third molar extractions when compared to conventional sutures? A systematic review and meta-analysis","volume":"10","author":"M WA Gon\u00e7alves","year":"2023","journal-title":"Heliyon"},{"issue":"01","key":"ref16","first-page":"47","article-title":"Cyanoacrylate vs. sutures in clean and clean-contaminated surgical wounds - a randomised control study","volume":"9","author":"K Aravind","year":"2024","journal-title":"Innov Surg Sci"},{"issue":"18","key":"ref17","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.3390\/ani14182678","article-title":"Cyanoacrylate adhesives for cutaneous wound closure","volume":"14","author":"I S Viana","year":"2024","journal-title":"Animals (Basel)"}],"container-title":["The Journal of Knee Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2796-8586.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:30:55Z","timestamp":1783463455000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2796-8586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":17,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2026,7,7]]},"published-print":{"date-parts":[[2026,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2796-8586","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1538-8506","1938-2480"],"issn-type":[{"value":"1538-8506","type":"print"},{"value":"1938-2480","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]}}}