{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:55:08Z","timestamp":1782168908006,"version":"3.54.5"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endoscopic resection (ER) of large (\u226515 mm) duodenal laterally spreading lesions (D-LSLs) is now standard of care. Data on prevalence, risk factors, and management of strictures after ER of D-LSL are absent; we sought to evaluate this in a large tertiary referral cohort.<\/jats:p>\n                  <jats:p>A prospective cohort of ER-treated D-LSLs in an expert center was retrospectively analyzed. Strictures were considered \u201csevere\u201d if patients experienced obstructive symptoms, \u201cmoderate\u201d if a standard gastroscope (diameter 9.9 mm) could not pass the stenosis, or \u201cmild\u201d if there was resistance on successful passage. When necessary, dilation was performed every 2\u20134 weeks until scope passage without resistance. Primary outcomes included stricture prevalence, risk factors, and management.<\/jats:p>\n                  <jats:p>Over 193 months until February 2023, 246 lesions in 239 patients were included (median age 70 years [interquartile range (IQR) 63\u201377]; 51.5% male; median lesion size 35 mm [IQR 22.5\u201347.5]). Overall, 30 resections (12.2%) resulted in stricture (14 mild [46.7%], 4 moderate [13.3%], and 12 severe [40%]), and 18 (7.3%) required balloon dilation (median 2 sessions [IQR 0\u20136]). On multivariable analysis, post-ER defect circumference \u226580% was the strongest independent predictor of stricture formation (OR 60.2, 95%CI 17.5\u2013254.2; P &lt; 0.001). Incidence of stricture formation with ER defects of \u226580%, 60%\u201379%, and &lt;60% was 72.2% (26\/36), 12.5% (4\/32), and 0% (0\/178), respectively. All severe strictures occurred in ER defects \u226580%.<\/jats:p>\n                  <jats:p>ER defect circumference strongly predicted stricture formation following ER of D-LSLs. These findings can be used to guide informed consent and post-procedural care.<\/jats:p>","DOI":"10.1055\/a-2797-9841","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T23:56:21Z","timestamp":1773705381000},"page":"719-730","source":"Crossref","is-referenced-by-count":1,"title":["Endoscopic resection-related duodenal strictures: prevalence, risk factors, management, and outcomes"],"prefix":"10.1055","volume":"58","clinical-trial-number":[{"clinical-trial-number":"nct02306603","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-1834","authenticated-orcid":false,"given":"Julia L.","family":"Gauci","sequence":"first","affiliation":[{"name":"Westmead Hospital, New South Wales, Australia","place":["Sydney"],"department":["Department of Gastroenterology and 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