{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:10:11Z","timestamp":1778227811750,"version":"3.51.4"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Effective strategies to prevent delayed bleeding (DB) following endoscopic mucosal resection (EMR) for large superficial non-ampullary duodenal tumors (SNADTs) remain limited. Octreotide exerts pharmacological effects that may influence hemostasis and thereby reduce bleeding risk. This exploratory study aimed to evaluate the association between postprocedural octreotide use and DB after duodenal EMR for large SNADTs.<\/jats:p>\n                  <jats:p>This single-center, exploratory, retrospective study included all hot EMRs for large SNADTs \u2265 10 mm (2015\u20132024). Routine post-procedural intravenous octreotide (50 \u03bcg\/h) was introduced in 2022, administered immediately post-EMR at 50 \u03bcg\/hour during overnight observation. DB was defined as clinically significant bleeding within 30 days requiring prolonged hospitalization, readmission, or intervention.<\/jats:p>\n                  <jats:p>A total of 107 SNADTs (median diameter 25 mm; interquartile range 15\u201340) were resected, including 33 treated with octreotide. Overall, DB occurred in 20% of patients (21\/107), including 24% (18\/74) in the control group and 9% (3\/33) in the octreotide group. In logistic regression adjusting for lesion size and propensity score, octreotide showed a non-significant trend toward reduced DB overall (odds ratio [OR] 0.34; 95% confidence interval [CI] 0.08\u20131.17; P = 0.11). In the subgroup of lesions \u2265 30 mm, octreotide use was associated with a significantly lower odds of DB (OR 0.21; 95% CI 0.039\u20130.89; P = 0.045), whereas this association was not observed in smaller lesions.<\/jats:p>\n                  <jats:p>In this exploratory study, postprocedural intravenous octreotide appeared to be associated with a lower occurrence of DB after EMR for large SNADTs (\u2265 30 mm). Larger, prospective studies are warranted to confirm these findings.<\/jats:p>","DOI":"10.1055\/a-2798-2041","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:39:12Z","timestamp":1773967152000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Octreotide for prevention of delayed bleeding after endoscopic mucosal resection for large superficial non-ampullary duodenal tumors"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9112-0707","authenticated-orcid":false,"given":"Cecile Maxime","family":"Van De Leur","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon MG","family":"Moons","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Vleggaar","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Didden","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1055\/a-1442-2395","article-title":"Endoscopic management of superficial nonampullary duodenal tumors: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"53","author":"G 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