{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:45:16Z","timestamp":1789076716189,"version":"build-2803163510"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["5U54GM115428"],"award-info":[{"award-number":["5U54GM115428"]}]},{"name":"NIH-National Heart, Lung, and Blood Institute","award":["K23HL148394"],"award-info":[{"award-number":["K23HL148394"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Transcatheter patent ductus arteriosus closure (TCPC) has been increasingly used in preterm infants. Hemodynamically significant patent ductus arteriosus (hsPDA) owing to ductal steal and changes in kidney perfusion is associated with the risk of acute kidney injury (AKI) and changes in kidney function. There is limited evidence describing changes in kidney function following TCPC and factors affecting the same. We conducted this study with aim of reviewing the prevalence of AKI and changes in kidney function following TCPC in preterm infants.<\/jats:p>\n                  <jats:p>A single-center retrospective cohort study was conducted to collect data from January 1, 2017, to February 29, 2024. Preterm infants born &lt;29\u2009w of gestational age (GA) receiving TCPC were included in the study. The primary outcome was AKI prevalence and kidney function following TCPC. AKI was defined as per the modified neonatal kidney disease: Improving Global Outcomes (KDIGO) criteria using serum creatinine (SCr) and urine output.<\/jats:p>\n                  <jats:p>A total of 89 infants fulfilled inclusion criteria. Included infants were predominantly female (50, 59.7%), had median GA of 25\u2009w (IQR: 24\u201327), and median birth weight of 700\u2009g (IQR: 600\u2013863). AKI developed in five infants (5.6%) following TCPC using SCr criteria. Four infants (4.5%) had stage 1 and one (1.1%) had stage 2 AKI. Overall, 14% reduction in SCr levels was seen following TCPC (median pre-TCPC, 0.28\u2009mg\/dL [IQR: 0.21\u20130.35], median, 5 to 7 days post-TCPC, 0.24\u2009mg\/dL [IQR: 0.18\u20130.29], p\u2009&lt;\u20090.001). Infants who developed AKI had an initial rise in SCr followed by 37% reduction by 5 to 7 days (pre-TCPC: 0.41\u2009mg\/dL [IQR: 0.27\u20130.51]; median, 24\u2009hours post, 0.57\u2009mg\/dL [IQR: 0.29\u20131.22]; median, 5 to 7 days post, 0.26\u2009mg\/dL [IQR: 0.19\u20130.67], p\u2009=\u20090.07).<\/jats:p>\n                  <jats:p>In preterm infants undergoing TCPC, a small percentage of infants developed mild AKI which improved quickly within 1 week post-TCPC. Overall, there was a significant and persistent improvement in kidney function following TCPC.<\/jats:p>","DOI":"10.1055\/a-2798-8294","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:01:55Z","timestamp":1769731315000},"page":"1572-1579","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Kidney Function and Acute Kidney Injury following Transcatheter Patent Ductus Arteriosus Closure in Preterm Infants"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5984-4505","authenticated-orcid":false,"given":"Dipen","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Neonatology, University of Mississippi Medical Center, Jackson, Mississippi, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Michael","family":"South","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Nephrology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5949-7304","authenticated-orcid":false,"given":"Parvesh Mohan","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/ Neonatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.semperi.2011.09.022","article-title":"Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?","volume":"36","author":"R I Clyman","year":"2012","journal-title":"Semin Perinatol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41372-021-01277-2","article-title":"Natural evolution of the patent ductus arteriosus in the extremely premature newborn and respiratory outcomes","volume":"42","author":"G de Carvalho Nunes","year":"2022","journal-title":"J Perinatol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"e2025071425","DOI":"10.1542\/peds.2025-071425","article-title":"Patent ductus arteriosus in preterm infants","volume":"155","author":"N Ambalavanan","year":"2025","journal-title":"Pediatrics"},{"issue":"S 01","key":"ref4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3109\/14767058.2011.607564","article-title":"Patent ductus arteriosus: patho-physiology, hemodynamic effects and clinical complications","volume":"24","author":"G Capozzi","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"e0187764","DOI":"10.1371\/journal.pone.0187764","article-title":"Incidence and outcomes of acute kidney injury in extremely-low-birth-weight infants","volume":"12","author":"C C Lee","year":"2017","journal-title":"PLoS One"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00467-019-4194-5","article-title":"Patent ductus arteriosus is associated with acute kidney injury in the preterm infant","volume":"34","author":"B Majed","year":"2019","journal-title":"Pediatr Nephrol"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"e2023065182","DOI":"10.1542\/peds.2023-065182","article-title":"Acute kidney injury in neonates: a meta-analysis","volume":"154","author":"J Meena","year":"2024","journal-title":"Pediatrics"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/apa.70001","article-title":"Employing a haemodynamic score to predict acute kidney injury in infants with patent ductus arteriosus","volume":"114","author":"D Wildes","year":"2025","journal-title":"Acta Paediatr"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.amjcard.2022.07.013","article-title":"Renal function after transcatheter Piccolo patent ductus arteriosus closure with contrast angiography in extremely premature infants","volume":"181","author":"C Herron","year":"2022","journal-title":"Am J Cardiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"113712","DOI":"10.1016\/j.jpeds.2023.113712","article-title":"Current trends in invasive closure of patent ductus arteriosus in very low birth weight infants in United States children's hospitals, 2016-2021","volume":"263","author":"K C Lai","year":"2023","journal-title":"J Pediatr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"113716","DOI":"10.1016\/j.jpeds.2023.113716","article-title":"Trends in procedural closure of the patent ductus arteriosus among infants born at 22 to 30 weeks' gestation","volume":"263","author":"Z S Shah","year":"2023","journal-title":"J Pediatr"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1007\/s00431-024-05481-y","article-title":"Post-ligation cardiac syndrome after surgical versus transcatheter closure of patent ductus arteriosus in low body weight premature infants: a multicenter retrospective cohort study","volume":"183","author":"P 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