{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T17:03:16Z","timestamp":1772902996140,"version":"3.50.1"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Measurement of D-dimer, a fibrin degradation product, is crucial for diagnosing thrombotic and fibrinolytic conditions. Despite its expanding utility, D-dimer testing faces challenges due to varying assay methodologies and nonstandardized reporting. To understand D-dimer reporting practices, the College of American Pathologists Hemostasis and Thrombosis Committee analyzed proficiency testing data from D-dimer surveys conducted between 2020 and 2023 across multiple laboratories. The data demonstrate that laboratories commonly report units that differ from the assay package insert when reporting their proficiency testing results. We sought to assess variability in reporting practices and opportunities for improvement in D-dimer reporting amongst participants. To accomplish this, we harmonized all D-dimer results to ng\/mL fibrinogen equivalent units from one distributed sample and assessed distinct populations of entries per instrument\/reagent combination. Notable trends emerged from this analysis. Data from laboratories using the same instrument\/reagent combinations clustered around different means, suggesting issues with unit reporting and\/or conversion. Entries reported in mg\/L or ug\/mL D-dimer units commonly exhibited significant deviations from the dominant population. For one instrument\/reagent combination, most reported values differed by approximately twice the certificate of analysis value. This analysis highlights potential issues with D-dimer reporting in proficiency testing. Whether these issues translate into issues with clinical D-dimer reporting requires further study.<\/jats:p>","DOI":"10.1055\/a-2803-3165","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:56:54Z","timestamp":1770422214000},"source":"Crossref","is-referenced-by-count":0,"title":["D-Dimer Reporting and Harmonization: Analysis of College of American Pathologists D-Dimer Proficiency Testing Program"],"prefix":"10.1055","author":[{"given":"Eric","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, Texas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi J.","family":"Smock","sequence":"additional","affiliation":[{"name":"Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taryn","family":"Cazzolli","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, Texas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Dlott","sequence":"additional","affiliation":[{"name":"The Department of Laboratory Medicine and Pathology, Mayo Clinic Jacksonville, Jacksonville, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Lickteig","sequence":"additional","affiliation":[{"name":"The Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of American Pathologists, Northfield, Illinois, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Mulvey","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Montefiore Medical Center, Bronx, New York, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morayma R.","family":"Gil","sequence":"additional","affiliation":[{"name":"The Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Rollins-Raval","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Teruya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Texas Children's Hospital, Houston, Texas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Volod","sequence":"additional","affiliation":[{"name":"The Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chance A.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey D.","family":"Wool","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole D.","family":"Zantek","sequence":"additional","affiliation":[{"name":"The Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Goodwin IV","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont Medical Center, Burlington, Vermont, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/ajh.25482","article-title":"The D-dimer assay","volume":"94","author":"E D Johnson","year":"2019","journal-title":"Am J Hematol"},{"key":"ref2","first-page":"1","article-title":"D-dimer: an overview of hemostasis and fibrinolysis, assays, and clinical applications","volume":"69","author":"J D Olson","year":"2015","journal-title":"Adv Clin Chem"},{"issue":"8735","key":"ref3","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0140-6736(91)92158-X","article-title":"Measurement of D-dimer in 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Hemost"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"119880","DOI":"10.1016\/j.cca.2024.119880","article-title":"The performance of quantitative D-dimer assays in Chinese clinical laboratories by analyzing data from National External Quality Assessment Scheme","volume":"562","author":"C Li","year":"2024","journal-title":"Clin Chim Acta"},{"issue":"S 01","key":"ref12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/ijlh.12998","article-title":"What have we learned from coagulation laboratory participation in external quality programs?","volume":"41","author":"K J Smock","year":"2019","journal-title":"Int J Lab Hematol"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"102335","DOI":"10.1016\/j.rpth.2024.102335","article-title":"D-dimer diagnostics: can I use any D-dimer assay? 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