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The basis of many workplace problems may therefore not be isolated causes, but rather an underlying sensitization process as an expression of dysfunctional regulatory feedback loops. This underlying background should be considered before initiating therapy. Otherwise, there is a significant risk of misguided treatment, which often leads to the chronification of the condition.<\/jats:p>","DOI":"10.1055\/a-2803-9867","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:15:38Z","timestamp":1773965738000},"page":"444-450","source":"Crossref","is-referenced-by-count":0,"title":["Central Sensitization as a Risk Factor in Work-related Musculoskeletal Pain \u2013 New Aspects of Functional Disorders"],"prefix":"10.1055","volume":"164","author":[{"given":"Gerhard","family":"Opitz","sequence":"additional","affiliation":[{"name":"MVZ M\u00fcnchen Bogenhausen, Deutschland","place":["M\u00fcnchen"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1097\/CORR.0000000000002904","article-title":"High Prevalence of Work-related Musculoskeletal Disorders and Limited Evidence-based Ergonomics in Orthopaedic Surgery: A Systematic Review","volume":"482","author":"N Vasireddi","year":"2024","journal-title":"Clin Orthop Relat Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1007\/s00482-016-0107-8","article-title":"Stressinduzierte Hyperalgesie (SIH) als Folge von emotionaler Deprivation und psychischer Traumatisierung in der Kindheit","volume":"30","author":"UT Egle","year":"2016","journal-title":"Schmerz"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.math.2005.01.004","article-title":"A comparison of symptomatic and asymptomatic office workers performing monotonous keyboard work\u20141: Neck and shoulder muscle recruitment patterns","volume":"10","author":"GPY Szeto","year":"2005","journal-title":"Man Ther"},{"key":"ref4","first-page":"1892","article-title":"[Psychological stress and musculoskeletal disorders: psychobiological mechanisms. 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