{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T23:26:43Z","timestamp":1786750003834,"version":"build-2736575974"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lactococcus lactis (L. lactis) is widely used in fermented foods and has immunomodulatory properties. However, its effects on allergic rhinitis remain unclear.<\/jats:p>\n                  <jats:p>This study evaluated the efficacy of L. lactis 11\/19-B1 in mitigating allergic rhinitis symptoms in a mouse model.<\/jats:p>\n                  <jats:p>Female BALB\/c mice were fed a diet supplemented with heat-killed L. lactis 11\/19-B1, while allergic rhinitis was induced via intraperitoneal and intranasal administration of ovalbumin (OVA). The positive control group received a standard diet without L. lactis 11\/19-B1. Sneezing frequency was recorded, and tissue samples were collected for analysis. Serum OVA-immunoglobulin E (IgE) levels were also measured, nasal mucosa histopathology assessed, and the interleukin 4 (IL-4), interferon gamma (IFN-\u03b3), T helper (Th) 1\/Th2 balance in cluster of differentiation (CD) 4+ T cells analyzed by flow cytometry (FCM).<\/jats:p>\n                  <jats:p>Mice receiving L. lactis 11\/19-B1 showed significantly reduced sneezing frequency and decreased eosinophil infiltration in the nasal mucosa. No significant changes in serum OVA-IgE levels were observed. Flow cytometry analysis showed a significant increase in the Th1\/Th2 ratio in Peyer's patches in the L. lactis 11\/19-B1 group compared with the positive control group.<\/jats:p>\n                  <jats:p>These findings suggest that L. lactis 11\/19-B1 alleviates allergic rhinitis symptoms by modulating the Th1\/Th2 balance and reducing eosinophil infiltration, independently of IgE suppression. These findings highlight its potential as a dietary supplement for allergic disease management .<\/jats:p>","DOI":"10.1055\/a-2804-6274","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T22:30:46Z","timestamp":1786746646000},"page":"001-007","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Lactococcus lactis 11\/19-B1 in a Mouse Model of Allergic Rhinitis"],"prefix":"10.1055","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-9135","authenticated-orcid":false,"given":"Toshihiko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Fukushima Medical University Aizu Medical Center, Fukushima, Japan"},{"name":"Department of Microbiology, Fukushima Medical University, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomu","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Fukushima Medical University, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Fukushima Medical University, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Fukushima Medical University Aizu Medical Center, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Suzutani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Fukushima Medical University, Fukushima, Japan"},{"name":"Ohara General Hospital, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref1","volume-title":"WAO White Book on Allergy: Update 2013","author":"R Pawankar","year":"2013"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.alit.2022.11.003","article-title":"Executive summary: Japanese guidelines for allergic rhinitis 2020","volume":"72","author":"M Okano","year":"2023","journal-title":"Allergol Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13223-019-0375-9","article-title":"CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria","volume":"15","author":"M N Fein","year":"2019","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/14656566.2018.1543401","article-title":"Current therapeutical strategies for allergic rhinitis","volume":"20","author":"L Klimek","year":"2019","journal-title":"Expert Opin Pharmacother"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3390\/pathogens11010080","article-title":"Diagnosis and Treatment of Local Allergic Rhinitis","volume":"11","author":"T Terada","year":"2022","journal-title":"Pathogens"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.2147\/JAA.S382978","article-title":"Research Advances in the Treatment of Allergic Rhinitis by Probiotics","volume":"15","author":"P Liu","year":"2022","journal-title":"J Asthma Allergy"},{"issue":"07","key":"ref7","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/exd.14602","article-title":"Pharmacogenomics for the efficacy and side effects of antihistamines","volume":"31","author":"L Li","year":"2022","journal-title":"Exp Dermatol"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1365-2249.2009.04010.x","article-title":"Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis","volume":"158","author":"M Okano","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"101875","DOI":"10.1016\/j.pupt.2019.101875","article-title":"The leukotriene receptor antagonist Montelukast can induce adverse skin reactions in asthmatic patients","volume":"60","author":"E Di Salvo","year":"2020","journal-title":"Pulm Pharmacol Ther"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1248\/bpb.30.2163","article-title":"Effects of Lactobacillus acidophilus strain L-55 on experimental allergic rhinitis in BALB\/c mice","volume":"30","author":"Y Sunada","year":"2007","journal-title":"Biol Pharm Bull"},{"issue":"05","key":"ref11","first-page":"628","article-title":"[Clinical effects of Lactobacillus acidophilus strain L-55-contained yogurt on symptoms of Japanese cedar pollen allergy]","volume":"61","author":"G Kimura","year":"2012","journal-title":"Arerugi"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3168\/jds.S0022-0302(05)72714-4","article-title":"Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study","volume":"88","author":"Y Ishida","year":"2005","journal-title":"J Dairy Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0168-1605(98)00128-7","article-title":"Demonstration of safety of probiotics \u2013 a review","volume":"44","author":"S Salminen","year":"1998","journal-title":"Int J Food Microbiol"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1017\/S0954422410000090","article-title":"The probiotic paradox: live and dead cells are biological response modifiers","volume":"23","author":"C A Adams","year":"2010","journal-title":"Nutr Res Rev"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1348-0421.2004.tb03490.x","article-title":"New Lactococcus strain with immunomodulatory activity: enhancement of Th1-type immune response","volume":"48","author":"H Kimoto","year":"2004","journal-title":"Microbiol Immunol"},{"issue":"07","key":"ref16","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.3390\/microorganisms11071787","article-title":"In Vivo Functional Properties of Dairy Bacteria","volume":"11","author":"G Aprea","year":"2023","journal-title":"Microorganisms"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5582\/ddt.2016.01022","article-title":"Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm","volume":"10","author":"S Nishida","year":"2016","journal-title":"Drug Discov Ther"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.3390\/nu10111778","article-title":"A Double-Blind Controlled Study to Evaluate the Effects of Yogurt Enriched with Lactococcus lactis 11\/19-B1 and Bifidobacterium lactis on Serum Low-Density Lipoprotein Level and Antigen-Specific Interferon-\u03b3 Releasing Ability","volume":"10","author":"K Nishiyama","year":"2018","journal-title":"Nutrients"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.3390\/microorganisms11122949","article-title":"Characterization of Lactococcus lactis 11\/19-B1 Isolated from Kiwi Fruit as a Potential Probiotic and Paraprobiotic","volume":"11","author":"K Ishioka","year":"2023","journal-title":"Microorganisms"},{"issue":"03","key":"ref20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3390\/nu12030763","article-title":"Effect of the Lactococcus Lactis 11\/19-B1 Strain on Atopic Dermatitis in a Clinical Test and Mouse Model","volume":"12","author":"T Suzuki","year":"2020","journal-title":"Nutrients"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5415\/apallergy.2011.1.3.157","article-title":"Overview on the pathomechanisms of allergic rhinitis","volume":"1","author":"R Pawankar","year":"2011","journal-title":"Asia Pac Allergy"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3341","article-title":"Eosinophils: changing perspectives in health and disease","volume":"13","author":"H F Rosenberg","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"02","key":"ref23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2332\/allergolint.11-OA-0388","article-title":"Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen","volume":"61","author":"Y Hara","year":"2012","journal-title":"Allergol Int"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0091-6749(00)90187-8","article-title":"Chemokine production by the BEAS-2B human bronchial epithelial cells: differential regulation of eotaxin, IL-8, and RANTES by TH2- and TH1-derived cytokines","volume":"105","author":"T Fujisawa","year":"2000","journal-title":"J Allergy Clin Immunol"},{"issue":"02","key":"ref25","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1164\/ajrccm\/146.2.374","article-title":"CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea","volume":"146","author":"H Nakajima","year":"1992","journal-title":"Am Rev Respir Dis"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12934-017-0669-x","article-title":"A review on Lactococcus lactis: from food to factory","volume":"16","author":"A A Song","year":"2017","journal-title":"Microb Cell Fact"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbiosc.2022.10.010","article-title":"Immunomodulatory action of Lactococcuslactis","volume":"135","author":"L AK Saleena","year":"2023","journal-title":"J Biosci Bioeng"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00130832-200412000-00010","article-title":"Role of regulatory dendritic cells in allergy and asthma","volume":"4","author":"O Akbari","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jaci.2016.06.003","article-title":"Regulatory T cells in allergic diseases","volume":"138","author":"M Noval Rivas","year":"2016","journal-title":"J Allergy Clin Immunol"},{"issue":"03","key":"ref30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4168\/aair.2010.2.3.199","article-title":"The Effects of Lactobacillus rhamnosus on the Prevention of Asthma in a Murine Model","volume":"2","author":"J Yu","year":"2010","journal-title":"Allergy Asthma Immunol Res"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1038\/s41598-017-02260-8","article-title":"Lactic acid bacteria-specific induction of CD4+Foxp3+T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling","volume":"7","author":"L Fu","year":"2017","journal-title":"Sci Rep"},{"issue":"02","key":"ref32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1254\/jphs.08028FP","article-title":"Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic effect","volume":"107","author":"S Dev","year":"2008","journal-title":"J Pharmacol Sci"}],"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2804-6274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T22:30:50Z","timestamp":1786746650000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2804-6274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,8,14]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["a28046274"],"URL":"https:\/\/doi.org\/10.1055\/a-2804-6274","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]}}}