{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:20:30Z","timestamp":1790079630555,"version":"4.0.1"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objective of this study is to assess reticulocyte\u2013hemoglobin (RET\u2013He) and daily iron dosing with 2-year cognitive outcomes.<\/jats:p>\n                  <jats:p>A multicenter retrospective cohort study of 78 infants born between 2014 and 2018 at less than 28 weeks' gestation or less than 1,250\u2009g birth weight throughout level III or IV neonatal intensive care units (NICUs). RET\u2013He measurement, iron supplementation, and the Bayley Scales of Infant and Toddler Development-III (Bayley-III) test were analyzed using multiple linear regression models.<\/jats:p>\n                  <jats:p>For every 1\u2009mg\/kg increase in mean total daily iron supplementation, the Bayley-III cognitive score increased by 2.9 points (95% confidence interval [CI]: 0.4\u20135.4, p\u2009=\u20090.023). No associations were identified between minimum or maximum RET\u2013He and Bayley-III cognitive outcomes. Infants with a RET\u2013He value\u2009&lt;\u200929 pg tended to be 2.53 times more likely to have a Bayley-III language score below 70 (odds ratio: 2.53, 95% CI: 0.92\u20136.95, p\u2009=\u20090.071). Thirty-eight out of 78 (38.4%) infants were iron-deficient during their NICU hospitalization, with at least one RET\u2013He\u2009&lt;\u200929 pg.<\/jats:p>\n                  <jats:p>An association was identified between a higher mean daily iron dose and improved cognitive outcomes for infants, but not between the iron index RET\u2013He and neurodevelopmental outcomes. Iron deficiency remains common among NICU patients undergoing follow-up, suggesting that standard iron dosing may be inadequate for high-risk neonates.<\/jats:p>","DOI":"10.1055\/a-2806-3017","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:33:11Z","timestamp":1771633991000},"page":"1621-1625","source":"Crossref","is-referenced-by-count":2,"title":["Iron Deficiency Screening with Reticulocyte\u2013Hemoglobin Content and 2-Year Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5228-6501","authenticated-orcid":false,"given":"Whitley N.","family":"Hulse","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Newborn Nursery, Department of Pediatrics, University of Wisconsin, Madison, Wisconsin, United States"},{"name":"Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-0290","authenticated-orcid":false,"given":"Timothy M.","family":"Bahr","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, Utah, United States"},{"name":"Department of Neonatology, Intermountain Healthcare, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"Ostrander","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, University of Utah Health, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah Health, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin K.","family":"Ohls","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara L.","family":"DuPont","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4274\/Tjh.2012.0107","article-title":"Clinical significance of reticulocyte hemoglobin content in the diagnosis of iron deficiency anemia","volume":"30","author":"M Karag\u00fclle","year":"2013","journal-title":"Turk J 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