{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:07:48Z","timestamp":1789175268845,"version":"build-2803163510"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100005937","name":"Cheng Hsin General Hospital Foundation","doi-asserted-by":"crossref","award":["CY11402-1, CY11402-2"],"award-info":[{"award-number":["CY11402-1, CY11402-2"]}],"id":[{"id":"10.13039\/501100005937","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007354","name":"Yen Tjing Ling Medical Foundation","doi-asserted-by":"crossref","award":["CI-113-32, CI-113-30, CI-114-35"],"award-info":[{"award-number":["CI-113-32, CI-113-30, CI-114-35"]}],"id":[{"id":"10.13039\/501100007354","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kun-Po Soo Medical Foundation"},{"name":"Ministry of Science and Technology, Taiwan","award":["MOST 109-2314-B-010-050-MY3, MOST111-2314-B-075 -0,MOST 111-2314-B-075 -013, NSTC113-2314-B-075-042,MOST110-2314-B-075-026, MOST110-2314-B-075-024 -MY"],"award-info":[{"award-number":["MOST 109-2314-B-010-050-MY3, MOST111-2314-B-075 -0,MOST 111-2314-B-075 -013, NSTC113-2314-B-075-042,MOST110-2314-B-075-026, MOST110-2314-B-075-024 -MY"]}]},{"name":"Taipei, Taichung, Kaohsiung Veterans General Hospital, Tri-Service General Hospital, Academia Sinica Joint Research Program","award":["VTA112-V1-6-1, VTA114-V1-4-1"],"award-info":[{"award-number":["VTA112-V1-6-1, VTA114-V1-4-1"]}]},{"name":"Veterans General Hospitals and University System of Taiwan Joint Research Program","award":["VGHUST112-G1-8-1, VGHUST114-G1-9-1"],"award-info":[{"award-number":["VGHUST112-G1-8-1, VGHUST114-G1-9-1"]}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V113C-039, V113C-011, V113C-010, V114C-089,V114C-064, V114C-217"],"award-info":[{"award-number":["V113C-039, V113C-011, V113C-010, V114C-089,V114C-064, V114C-217"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As accumulating evidence suggests the antisuicidal properties of ketamine,\nelucidating its underlying mechanisms and predictors of treatment response\nhas become crucial. Whether a combination of clinical markers can enhance\nthe prediction of the antisuicidal response to ketamine remains unclear.<\/jats:p>\n                  <jats:p>Using data from our previous randomized placebo-controlled and open-label\ntrials, this post hoc analysis evaluated 67 patients with\ntreatment-resistant depression and prominent suicidal ideation who received\na single ketamine infusion of 0.5 mg\/kg. A classification and regression\ntree model was used to identify the combinations of clinical and demographic\ncharacteristics at baseline that can predict the antisuicidal response to\nketamine infusion.<\/jats:p>\n                  <jats:p>Combinations of clinical predictors, including mild or moderate depression\nseverity, a shorter duration of the current episode, no more than four\ntrials of antidepressant failures, low or moderate current suicide risks,\nand a history of suicide attempts, offered superior predictive power for the\nrapid and sustained antisuicidal effects of sub-anesthetic ketamine\ninfusion, outperforming the predictive power of any individual\npredictor.<\/jats:p>\n                  <jats:p>Clinicians can use our findings to identify individuals who are most likely\nto benefit from the antisuicidal effects of ketamine. Further research is\nrequired to corroborate these findings.<\/jats:p>\n                  <jats:p>CART found combined baseline markers, including mild\/moderate depression,\nshorter episode, \u22644 failed antidepressants, low\/moderate suicide risk, and\nprior attempts, predict rapid\/sustained antisuicidal response of\nsub-anesthetic ketamine in TRD.<\/jats:p>","DOI":"10.1055\/a-2807-8161","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:34:07Z","timestamp":1772152447000},"page":"328-337","source":"Crossref","is-referenced-by-count":0,"title":["Using Classification and Regression Tree Modeling to Investigate the\nEffects of Subanesthetic Ketamine Infusion on Remission of Suicidal\nSymptoms"],"prefix":"10.1055","volume":"59","clinical-trial-number":[{"clinical-trial-number":"umin000016985","registry":"10.18810\/umin-japan"},{"clinical-trial-number":"umin000023581","registry":"10.18810\/umin-japan"},{"clinical-trial-number":"umin000033760","registry":"10.18810\/umin-japan"},{"clinical-trial-number":"umin000033916","registry":"10.18810\/umin-japan"}],"author":[{"given":"Ping-Chung","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei,\nTaiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei,\nTaiwan"},{"name":"Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao\nTung University, Taipei, Taiwan"},{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University,\nTaipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Ping","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei,\nTaiwan"},{"name":"Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao\nTung University, Taipei, Taiwan"},{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University,\nTaipei, Taiwan"},{"name":"Department of Psychiatry, Cheng Hsin General Hospital,\nTaipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ta","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei,\nTaiwan"},{"name":"Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao\nTung University, Taipei, Taiwan"},{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University,\nTaipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ju","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei,\nTaiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei,\nTaiwan"},{"name":"Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao\nTung University, Taipei, Taiwan"},{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University,\nTaipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Mei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei,\nTaiwan"},{"name":"Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao\nTung University, Taipei, Taiwan"},{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University,\nTaipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chi","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei,\nTaiwan"},{"name":"Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao\nTung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chung","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Cheng Hsin General Hospital,\nTaipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1073","authenticated-orcid":false,"given":"Mu-Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei,\nTaiwan"},{"name":"Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao\nTung University, Taipei, Taiwan"},{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University,\nTaipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/wps.21120","article-title":"Treatment-resistant depression: definition, prevalence, detection, management,\nand investigational interventions","volume":"22","author":"R S McIntyre","year":"2023","journal-title":"World Psychiatry"},{"key":"ref2","first-page":"21","article-title":"Sequenced treatment alternatives to relieve depression (STAR*D) \u2013 Part 2: Study\noutcomes","volume":"46","author":"R H Howland","year":"2008","journal-title":"J Psychosoc Nurs Mental Health Serv"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jad.2018.06.045","article-title":"The burden of treatment-resistant depression: a systematic review of the\neconomic and quality of life literature","volume":"242","author":"K M Johnston","year":"2019","journal-title":"J Affective Disord"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jad.2018.04.016","article-title":"Treatment-resistant depression and suicidality","volume":"235","author":"I O Bergfeld","year":"2018","journal-title":"J Affective Disord"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/sltb.12022","article-title":"Treatment-resistant depression and risk of suicide","volume":"43","author":"P N Pfeiffer","year":"2013","journal-title":"Suicide Life-Threatening Behav"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpsychires.2021.01.014","article-title":"Treatment-resistant depression and risk of all-cause mortality and suicidality\nin Danish patients with major depression","volume":"135","author":"F H Gronemann","year":"2021","journal-title":"J Psychiatr Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1176\/appi.ajp.2017.17040472","article-title":"The effect of a single dose of intravenous ketamine on suicidal ideation: a\nsystematic review and individual participant data meta-analysis","volume":"175","author":"S T Wilkinson","year":"2018","journal-title":"Am J Psychiatry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/0004867419883341","article-title":"Ketamine for suicidal ideation in adults with psychiatric disorders: a\nsystematic review and meta-analysis of treatment trials","volume":"54","author":"K Witt","year":"2020","journal-title":"Aust N Z J Psychiatry"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-067194","article-title":"Ketamine for the acute treatment of severe suicidal ideation: double blind,\nrandomised placebo controlled trial","volume":"376","author":"M Abbar","year":"2022","journal-title":"BMJ"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1176\/appi.ajp.2017.17060647","article-title":"Ketamine for rapid reduction of suicidal thoughts in major depression: A\nmidazolam-controlled randomized clinical trial","volume":"175","author":"M F Grunebaum","year":"2018","journal-title":"Am J Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/JCMA.0000000000001150","article-title":"Autism, youth suicide, and psychedelics: A review of the 21st century\nevidence","volume":"87","author":"M H Chen","year":"2024","journal-title":"J Chin Med Assoc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jad.2018.07.077","article-title":"Characterizing the course of suicidal ideation response to ketamine","volume":"241","author":"E D Ballard","year":"2018","journal-title":"J Affective 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Disord"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1038\/s41386-019-0480-y","article-title":"Maintenance of antidepressant and antisuicidal effects by D-cycloserine among\npatients with treatment-resistant depression who responded to low-dose ketamine\ninfusion: A double-blind randomized placebo-control study","volume":"44","author":"M H Chen","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1038\/npp.2017.94","article-title":"Dose-related effects of adjunctive ketamine in taiwanese patients with\ntreatment-resistant depression","volume":"42","author":"T P Su","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/ijnp\/pyad014","article-title":"A Randomized, double-blind, midazolam-controlled trial of low-dose ketamine\ninfusion in patients with treatment-resistant depression and prominent 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Res"}],"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2807-8161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:29:07Z","timestamp":1789172947000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2807-8161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":38,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,9,11]]},"published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2807-8161","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"value":"0176-3679","type":"print"},{"value":"1439-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}