{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:18:59Z","timestamp":1787613539273,"version":"build-2736575974"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Was ist neu?<\/jats:title>\n                  <jats:p>Chronischer Husten kann als Symptom, aber auch als eigenst\u00e4ndige Krankheit auftreten. Refrakt\u00e4rer chronischer Husten (RCC) und idiopathischer chronischer Husten (ICC) haben als eigenst\u00e4ndige Krankheit einen ICD-Zusatzcode: U69.6.<\/jats:p>\n                  <jats:p>Die neue Hustenleitlinie definiert bei jedem Patienten mit chronischem Husten eine obligate Basisdiagnostik. Diese beinhaltet Anamnese, k\u00f6rperliche Untersuchung, R\u00f6ntgenthorax in 2 Ebenen und eine Lungenfunktionspr\u00fcfung. Eine weitere Diagnostik soll nur durchgef\u00fchrt werden, wenn hierf\u00fcr ein klinischer Anhaltspunkt besteht. Zur Beurteilung des objektiven und subjektiven Schweregrads wird bald ein Hustenmonitoring mit kommerziell erh\u00e4ltlicher Software auf Smartwatch oder Smartphone m\u00f6glich sein.<\/jats:p>\n                  <jats:p>Es bestehen aufsteigende Verbindungen vom Hunstenzentrum im Hirnstamm zu den sensorischen, motorischen, limbischen pr\u00e4frontalen und frontalen Bereichen des Kortex, die f\u00fcr das Irritationsgef\u00fchl im Bereich der Atemwege verantwortlich sind. Im MRT zeigt sich, dass Patienten mit RCC\/ICC schon auf geringe Reize eine vermehrte Kortexaktivit\u00e4t zeigen.<\/jats:p>\n                  <jats:p>Wegen der verschiedenen Ph\u00e4notypen und Endotypen des chronischen Hustens, sind verschieden wirksame Medikamente notwendig. Ein Goldstandard existiert nicht.<\/jats:p>\n                  <jats:p>Gefapixant ist ein purinerger P2X3-ATP-Rezeptor-Antagonist und mit guten Ergebnissen f\u00fcr die Therapie des RCC\/ICC in gro\u00dfen Teilen Europas zugelassen. Schwierigkeit bei der Zulassung von Hustenmedikamenten macht generell der hohe Plazeboeffekt. Dieser ist subjektiv als auch objektiv messbar und mit der Wirkung des Medikaments auf die neuronale (zentrale) Sensitivit\u00e4t des Hustenreflexes zu erkl\u00e4ren.<\/jats:p>\n                  <jats:p>Um alle Ph\u00e4no- und Endotypen des chronischen Hustens abzudecken sind Neuentwicklungen erforderlich. Es befinden sich sowohl Antagonisten f\u00fcr periphere Rezeptoren als auch zentral wirkende Substanzen in Phase-2-Studien. Damit besteht Hoffnung auf baldige neue Zulassungen.<\/jats:p>","DOI":"10.1055\/a-2808-0041","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:32:26Z","timestamp":1787610746000},"page":"968-973","source":"Crossref","is-referenced-by-count":0,"title":["Chronischer Husten"],"prefix":"10.1055","volume":"151","author":[{"given":"Peter","family":"Kardos","sequence":"additional","affiliation":[{"name":"Lungenzentrum Maingau, Deutschland","place":["Frankfurt"],"department":["Pneumologie, Allergologie, Schlafmedizin"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/a-2550-3738","article-title":"S2k-Leitlinie Fach\u00e4rztliche Diagnostik und Therapie von erwachsenen Patienten mit Husten","volume":"79","author":"P 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