{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:51:39Z","timestamp":1791589899904,"version":"4.3.4"},"reference-count":115,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Der Hypoadrenokortizismus (HA) des Hundes erfordert eine lebenslange Substitutionstherapie von Gluko- und \u2013 in den meisten F\u00e4llen \u2013 auch Mineralokortikoiden. Zur Glukokortikoidsubstitution wird Prednisolon in einer Erhaltungsdosis von etwa 0,1 mg\/kg\/Tag eingesetzt. Alternative Pr\u00e4parate wie Hydrocortison, Dexamethason oder Methylprednisolon kommen seltener zum Einsatz. In der Veterin\u00e4rmedizin ist Desoxycorticosteronpivalat (DOCP) das einzige zugelassene parenterale Pr\u00e4parat zur Mineralokortikoid-Ersatztherapie in Europa.<\/jats:p>\n                  <jats:p>Die Zulassungsdosis betr\u00e4gt 2,2 mg\/kg alle 25\u201330 Tage (subkutan). Eine Studie zeigte, dass eine reduzierte Startdosis von 1,5 mg\/kg eine stabile Regulation erm\u00f6glicht.<\/jats:p>\n                  <jats:p>Fludrocortisonacetat (FC) ist ein Humanpr\u00e4parat, das eine Mineralokortikoid- und zus\u00e4tzlich eine gewisse Glukokortikoidwirkung besitzt. Es wurde vor der Zulassung von DOCP eingesetzt und muss bei Hunden umgewidmet werden. Die \u00fcbliche Dosierung betr\u00e4gt 0,01\u20130,02 mg\/kg\/Tag und wird auf zweimal t\u00e4glich verteilt. Untersuchungen zeigen, das DOCP dem FC \u00fcberlegen ist, da es mit weniger Nebenwirkungen, einer besseren Elektrolytkontrolle, einem verbesserten klinischen Zustand und einer h\u00f6heren Zufriedenheit der Tierhalter assoziiert ist.<\/jats:p>\n                  <jats:p>Eine engmaschige klinische und laborchemische Verlaufskontrolle ist essenziell, um \u00dcber- oder Unterdosierungen zu vermeiden und ggf. die Therapie anzupassen. Bei ad\u00e4quater Therapie ist die Prognose von Hunden mit HA insgesamt sehr gut.<\/jats:p>","DOI":"10.1055\/a-2811-5723","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:21:38Z","timestamp":1791588098000},"page":"324-330","source":"Crossref","is-referenced-by-count":0,"title":["Behandlungsstrategien beim Hypoadrenokortizismus des Hundes \u2013 ein aktueller \u00dcberblick"],"prefix":"10.1055","volume":"54","author":[{"given":"Deborah Anna","family":"Dobosz","sequence":"additional","affiliation":[{"name":"Kleintierklinik der LMU M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Wehner","sequence":"additional","affiliation":[{"name":"Kleintierklinik der LMU M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.2460\/javma.242.11.1549","article-title":"Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995\u20132010)","volume":"242","author":"T P Bellumori","year":"2013","journal-title":"J Am Vet Med Assoc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/jvim.13815","article-title":"Naturally Occurring Adrenocortical Insufficiency \u2013 An Epidemiological Study Based on a Swedish-Insured Dog Population of 525,028 Dogs","volume":"30","author":"J M Hanson","year":"2016","journal-title":"J Vet Intern Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/vetsci12080761","article-title":"Agreeing Language in Veterinary Endocrinology (ALIVE): Cushing's Syndrome and Hypoadrenocorticism-A 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