{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:23:21Z","timestamp":1792700601286,"version":"4.5.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In type 2 diabetes mellitus, the prevalence at diagnosis, incidence, and\n                    remission of erectile dysfunction are unknown. We evaluated the prevalence,\n                    incidence, remission, and predictors of erectile dysfunction in newly diagnosed\n                    and uncomplicated type 2 diabetic men. We consecutively enrolled 549 diabetic\n                    men without complications. Erectile dysfunction was diagnosed using the\n                    International Index for Erectile Function 5 questionnaire. Patients were\n                    followed up for 64.2\u00b122.1 months. At baseline, 133 patients had erectile\n                    dysfunction and 416 patients did not. The prevalence of erectile dysfunction was\n                    24.2%. Among the 416 patients without erectile dysfunction at baseline, 67\n                    (16.1%) patients developed erectile dysfunction at follow-up, with an erectile\n                    dysfunction incidence of 2.3%\/y. Among the 133 patients with erectile\n                    dysfunction at baseline, 27 (20.3%) patients had remission at follow-up, with an\n                    erectile dysfunction remission rate of 0.9%\/y. Multivariate analysis showed that\n                    age&gt;60 years, total testosterone levels of&lt;2.8 ng\/mL and uric acid levels\n                    of&gt;6 mg\/dL were predictors of erectile dysfunction at diagnosis. Predictors\n                    of erectile dysfunction incidence were age&gt;60 years, smoking and low total\n                    testosterone levels, whereas total testosterone levels of&gt;2.8 ng\/mL predicted\n                    erectile dysfunction remission. No significant association between therapeutic\n                    patient education and erectile dysfunction was observed. In conclusion, one\n                    quarter of men with newly diagnosed and uncomplicated type 2 diabetes has\n                    erectile dysfunction at diagnosis. The incidence of erectile dysfunction was\n                    2.3%\/y, while remission was 0.9%\/y. Older age, low total testosterone levels,\n                    and hyperuricemia were associated with erectile dysfunction at diabetes\n                    diagnosis, while older age, smoking, and total testosterone levels were the\n                    longitudinal predictors of erectile dysfunction.<\/jats:p>","DOI":"10.1055\/a-2813-5608","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:50:22Z","timestamp":1772495422000},"page":"114-120","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence, Incidence, and Remission of Erectile Dysfunction in Newly\n                    Diagnosed and Uncomplicated Type 2 Diabetic Men: The Role of Testosterone,\n                    Hyperuricemia, and Patient Education"],"prefix":"10.1055","volume":"58","author":[{"given":"Adriana","family":"Coppola","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Metabolism Unit, Istituto\n                    Clinico Beato Matteo, Vigevano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Gallotti","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Istituto Clinico Beato Matteo,\n                    Vigevano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Pujia","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine,\n                    University of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Montalcini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine,\n                    University of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colomba","family":"Falcone","sequence":"additional","affiliation":[{"name":"Centro Interdipartimentale di Medicina Molecolare per la\n                    Diagnosi e la Cura delle Malattie Cardiovascolari e Metaboliche (CIRMC),\n                    University of Pavia, Pavia, Italy"},{"name":"Cardiology Unit, Istituto di Cura Citta di Pavia, Pavia,\n                    Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Gazzaruso","sequence":"additional","affiliation":[{"name":"Endocrinology, Diabetes and Metabolism Unit, Istituto\n                    Clinico Beato Matteo, Vigevano, Italy"},{"name":"Department of Biomedical Sciences for Health, University\n                    of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/dme.13403","article-title":"High prevalence of erectile dysfunction in diabetes: A systematic review and\n                    meta-analysis of 145 studies","volume":"34","author":"Y 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obesity, testosterone, and patient education on the prevalence,\n                    incidence, and remission of sexual dysfunction in women with newly diagnosed and\n                    uncomplicated type 2 diabetes","volume":"90","author":"A Coppola","year":"2025","journal-title":"Endocrine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1368079","DOI":"10.3389\/fendo.2024.1368079","article-title":"Risk factors for erectile dysfunction in diabetes mellitus: a systematic review\n                    and meta-analysis","volume":"15","author":"D Dilixiati","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.2337\/dc20-1558","article-title":"Rapid changes in serum testosterone in men with newly diagnosed type 2 diabetes\n                    with intensive insulin and metformin","volume":"44","author":"Y Hu","year":"2021","journal-title":"Diabetes Care"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/jsm.12777","article-title":"The prevalence and the risk factors of testosterone deficiency in newly\n                    diagnosed and previously known type 2 diabetic men","volume":"12","author":"C H Ho","year":"2015","journal-title":"J Sex Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/17512433.2021.1938548","article-title":"The role of testosterone treatment in patients with metabolic disorders","volume":"14","author":"G Corona","year":"2021","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/andr.13088","article-title":"Erectile dysfunction in hyperuricemia: A prevalence meta-analysis and\n                    meta-regression study","volume":"10","author":"M Totaro","year":"2022","journal-title":"Andrology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"100319","DOI":"10.1016\/j.esxm.2020.100319","article-title":"Hyperuricemia is not an independent predictor of erectile dysfunction","volume":"9","author":"A T Tuokko","year":"2021","journal-title":"Sex Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12882-024-03621-y","article-title":"The association between uric acid and erectile dysfunction in US adults: NHANES\n                    2001-2004","volume":"25","author":"Y Fun Wang","year":"2024","journal-title":"BMC Nephrol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1159\/000514700","article-title":"Erectile dysfunction in type-2 diabetes mellitus patients: Predictors of early\n                    detection and treatment","volume":"105","author":"J Fan","year":"2021","journal-title":"Urol Int"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41392-024-01916-y","article-title":"Hyperuricemia and its related diseases: mechanisms and advances in therapy","volume":"9","author":"L Du","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s40265-017-0839-5","article-title":"Effects of allopurinol on endothelial function: A systematic review and\n                    meta-analysis of randomized placebo-controlled trials","volume":"78","author":"AF G Cicero","year":"2018","journal-title":"Drugs"},{"key":"ref27","first-page":"169","volume-title":"Physical activity and sexual dysfunction","author":"C Gazzaruso","year":"2023"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.3390\/nu14173525","article-title":"Gout and diet: A comprehensive review of mechanisms and management","volume":"14","author":"Y Zhang","year":"2022","journal-title":"Nutrients"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1007\/s40618-022-01859-7","article-title":"Adult- and late-onset male hypogonadism: The clinical practice guidelines of the\n                    Italian Society of Andrology and Sexual Medicine (SIAMS) and the Italian Society\n                    of Endocrinology (SIE)","volume":"45","author":"A M Isidori","year":"2022","journal-title":"J Endocrinol Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1210\/jc.2018-00229","article-title":"Testosterone therapy in men with hypogonadism: An endocrine society clinical\n                    practice guideline","volume":"103","author":"S Bhasin","year":"2018","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2813-5608.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:52:50Z","timestamp":1773791570000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2813-5608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":30,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,3,17]]},"published-print":{"date-parts":[[2026,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2813-5608","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}