{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:58:35Z","timestamp":1781135915095,"version":"3.54.1"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neonatal hypertension is uncommon but clinically significant due to its\n                        systemic complications. Data on the clinical course, etiologies, and\n                        outcomes of neonates receiving antihypertensive therapy in the neonatal\n                        intensive care unit are limited. This study aimed to describe the clinical\n                        characteristics, underlying etiologies, management strategies, and outcomes\n                        of neonates receiving antihypertensive therapy in a tertiary level 4\n                        NICU.<\/jats:p>\n                  <jats:p>We conducted a retrospective review of medical records of neonates admitted\n                        to the NICU between January 2024 and June 2025 who received antihypertensive\n                        treatment. Etiologies were classified as renal, vascular, or miscellaneous.\n                        Follow-up data were analyzed to identify persistence of hypertension after\n                        discharge.<\/jats:p>\n                  <jats:p>Of 17 neonates, 9 (52%) were preterm and 8 (47%) were term. Renal etiologies\n                        predominated (47%), including acute kidney injury, congenital anomalies of\n                        the kidney and urinary tract, and polycystic kidney disease. Vascular causes\n                        accounted for 5.8%, and miscellaneous etiologies, such as intracranial\n                        lesions and sepsis, for 47%. Monotherapy with amlodipine, enalapril, or\n                        captopril was used in most cases, while combination therapy was required in\n                        two neonates with renal etiologies. Four neonates (23.5%) were discharged on\n                        ongoing antihypertensive therapy, all with structural or genetic renal or\n                        vascular abnormalities.<\/jats:p>\n                  <jats:p>Neonatal hypertension is heterogeneous, with renal disorders being the most\n                        frequent cause. Persistent hypertension occurs mainly in neonates with\n                        structural renal or vascular abnormalities, while those with other causes\n                        often discontinue therapy before discharge. These findings highlight the\n                        importance of identifying neonates at risk for long-term complications.<\/jats:p>","DOI":"10.1055\/a-2814-4099","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:32:26Z","timestamp":1773102746000},"page":"232-236","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Neonates Receiving Antihypertensive\n                    Treatment"],"prefix":"10.1055","volume":"230","author":[{"given":"Zehra","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Ministry of Health\n                    Gaziantep City Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvis","family":"Kraja","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ministry of Health Gaziantep\n                    City Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samet","family":"Benli","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Ministry of Health Gaziantep\n                    City Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Ozlem","family":"Cam Delebe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Ministry of Health\n                    Gaziantep City Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin","family":"Ozdemiro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Ministry of Health\n                    Gaziantep City Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munevver Tugba","family":"Temel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Ministry of Health\n                    Gaziantep City Hospital, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1542\/pir.2019-0159","article-title":"Neonatal hypertension","volume":"41","author":"P Giri","year":"2020","journal-title":"Pediatr Rev"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41390-018-0018-8","article-title":"Incidence of neonatal hypertension in NICU patients: a multicenter study","volume":"84","author":"E J Kraut","year":"2018","journal-title":"Pediatr Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s00467-018-3977-4","article-title":"Neonatal hypertension: cases, causes, and clinical approach","volume":"34","author":"M C Starr","year":"2019","journal-title":"Pediatr Nephrol"},{"key":"ref4","first-page":"1271","article-title":"Introduction of new neonatal standard anthropometric measurements","volume":"114","author":"K Itabashi","year":"2010","journal-title":"Nihon Shonika Gakkai Zasshi"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/sj.ki.5002235","article-title":"Modified RIFLE criteria in critically ill children with acute kidney injury","volume":"71","author":"A Akcan-Arikan","year":"2007","journal-title":"Kidney Int"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1542\/peds.58.2.259","article-title":"A simple estimate of glomerular filtration rate in children derived from body\n                    length and plasma creatinine","volume":"58","author":"G J Schwartz","year":"1976","journal-title":"J Pediatr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1007\/s12098-020-03280-4","article-title":"Blood pressure outcomes in NICU-admitted infants with neonatal hypertension: a\n                    Pediatric Nephrology Research Consortium study","volume":"87","author":"K Rais-Bahrami","year":"2020","journal-title":"Indian J Pediatr"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"815201","DOI":"10.3389\/fped.2022.815201","article-title":"Neonatal hypertension: a comprehensive review","volume":"10","author":"P Roth","year":"2022","journal-title":"Front Pediatr"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s12098-021-03732-4","article-title":"Neonatal hypertension: an educational review","volume":"88","author":"M W Harer","year":"2021","journal-title":"Indian J Pediatr"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.clp.2021.11.003","article-title":"Neonatal hypertension","volume":"49","author":"R Hjorten","year":"2022","journal-title":"Clin Perinatol"},{"key":"ref11","volume-title":"Neonatal hypertension","author":"P Pattnaik","year":"2023"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e080207","DOI":"10.7363\/080207","article-title":"Neonatal hypertension: focus on diagnosis and therapy","volume":"8","author":"CD V Gon\u00e7alves","year":"2019","journal-title":"J Pediatr Neonatal Individ Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"7440","DOI":"10.12998\/wjcc.v11.i30.7440","article-title":"Pharmacogenomics-based individualized treatment of hypertension in preterm\n                    infants: a case report and review of the literature","volume":"11","author":"L F Tang","year":"2023","journal-title":"World J Clin Cases"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0895-7061(00)00278-8","article-title":"Treatment of hypertensive children with amlodipine","volume":"13","author":"J T Flynn","year":"2000","journal-title":"Am J Hypertens"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"645396","DOI":"10.1155\/2011\/645396","article-title":"Angiotensin-converting enzyme inhibitor (ACEI)-induced acute renal failure in\n                    premature newborns with congenital heart disease","volume":"2011","author":"A Sinha","year":"2011","journal-title":"Case Rep Nephrol"},{"key":"ref16","volume-title":"Furosemide","author":"T M Khan","year":"2023"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1007\/s00467-007-0604-6","article-title":"The hypertensive neonate","volume":"22","author":"J T Flynn","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00467-018-4056-6","article-title":"Outcomes of infants receiving chronic peritoneal dialysis: an analysis of the\n                    USRDS registry","volume":"34","author":"K R Sanderson","year":"2019","journal-title":"Pediatr Nephrol"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2814-4099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:29:07Z","timestamp":1781134147000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2814-4099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":18,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,6,5]]},"published-print":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2814-4099","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]}}}