{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:08:29Z","timestamp":1789600109405,"version":"build-2803163510"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The objective of this study is to explore real-world practices in managing sedation\u2013analgesia in a population of neonates with hypoxic\u2013ischemic encephalopathy undergoing therapeutic hypothermia.<\/jats:p>\n                  <jats:p>Retrospective data from neonates admitted with hypoxic\u2013ischemic encephalopathy to the neonatal intensive care unit of Lille University Hospital were collected, between December 31, 2018, and July 15, 2022. Drug and dosage of sedation\u2013analgesia during the 96\u2009hours following therapeutic hypothermia initiation were collected. Neonates were divided into four subgroups for principal component analysis, according to neurological examination at discharge: death, severe sequelae, moderate sequelae, no sequelae.<\/jats:p>\n                  <jats:p>Neonates with a favorable outcome were exposed to higher cumulative doses. They were more likely to be exposed to polypharmacy, midazolam, and dexmedetomidine, and increasing doses of these. Daily doses of opioids did not vary significantly. Newborns with acute renal failure had lower cumulative doses. There was no significant difference between newborns with and without hepatic cytolysis.<\/jats:p>\n                  <jats:p>Practice assessments highlight heterogeneity regarding sedation\u2013analgesia, especially within patient groups. Findings indicate that sedation\u2013analgesia is not reassessed as often as it should be to account for specific pharmacokinetic parameters and the physiologic course of recovery.<\/jats:p>","DOI":"10.1055\/a-2815-9871","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:51:27Z","timestamp":1772495487000},"page":"1723-1730","source":"Crossref","is-referenced-by-count":1,"title":["Sedation\u2013Analgesia Management in Neonates with Hypoxic\u2013Ischemic Encephalopathy under Therapeutic Hypothermia: Feedback from a Local Study on 51 Patients"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2262-8450","authenticated-orcid":false,"given":"Clement","family":"Basse","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Lille University Hospital, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1597-0320","authenticated-orcid":false,"given":"Mohamed Riadh","family":"Boukhris","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Lille University Hospital, Lille, France"},{"name":"Research Unit 2694\u2014METRICS, Health Technology Assessment and Medical Practices, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1984-015X","authenticated-orcid":false,"given":"Laurence","family":"Chaton","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research, Unit 1172, University of Lille, Lille, France"},{"name":"Department of Clinical Neurophysiology, Lille University Hospital, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-0336","authenticated-orcid":false,"given":"Laurent","family":"Storme","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Lille University Hospital, Lille, France"},{"name":"Research Unit 2694\u2014METRICS, Health Technology Assessment and Medical Practices, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-0250","authenticated-orcid":false,"given":"Emilie","family":"Bourel-Ponchel","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research, Joint Research Unit 1105, Research Group on Multimodal Analysis of Brain Fonction, University of Picardie Jules Verne, Amiens, France"},{"name":"Pediatric Neurophysiology Unit, Amiens-Picardie University Hospital, Amiens, 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