{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:59:28Z","timestamp":1785452368128,"version":"3.56.0"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"Zhejiang Provincial Traditional Chinese Medicine Science and\n                        Technology Project","award":["22025ZL124"],"award-info":[{"award-number":["22025ZL124"]}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang","doi-asserted-by":"crossref","award":["LQN25H080005"],"award-info":[{"award-number":["LQN25H080005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Project of Agriculture and Social Science\n                        of Ningbo Yinzhou District","award":["2022AS017"],"award-info":[{"award-number":["2022AS017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>T-cell acute lymphoblastic leukemia (T-ALL) remains a clinical challenge due to\n                    its high relapse rate and limited treatment options. This study aimed to\n                    investigate the cytotoxic effects of oleandrin on T-ALL and its underlying\n                    mechanism to explore novel therapeutic strategies. In human T-ALL cell lines, it\n                    inhibited cell growth and induced apoptosis in a dose- and time-dependent\n                    manner, with half-maximal inhibitory concentration (IC\u2085\u2080) values ranging from 16\n                    to 31\u2009nM. In mouse xenograft models, oleandrin reduced tumor burden and\n                    prolonged survival without significant toxicity. Integrated mechanistic studies,\n                    including network pharmacology, transcriptomics, and Western blot analysis,\n                    indicated that the anti-leukemic effects of oleandrin are associated with\n                    suppression of the PI3K\/AKT signaling pathway, as evidenced by reduced levels of\n                    key proteins such as PIK3CA, phosphorylated AKT (p-AKT), phosphorylated\n                        GSK3\u03b2 (p-GSK3\u03b2), c-Myc, Bcl-2, and Bcl-xL. These findings\n                    suggest oleandrin is a promising therapeutic candidate for T-ALL, likely through\n                    suppression of the PI3K\/AKT pathway.<\/jats:p>","DOI":"10.1055\/a-2816-0955","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:22:26Z","timestamp":1772756546000},"page":"891-900","source":"Crossref","is-referenced-by-count":0,"title":["Oleandrin Suppresses the PI3K\/AKT Pathway to Inhibit Growth and\n                    Induce Apoptosis in T-cell Acute Lymphoblastic Leukemia Cells and Xenograft\n                    Mice"],"prefix":"10.1055","volume":"92","author":[{"given":"Haihui","family":"Zhuang","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Biotechnology, Shanghai Jiao Tong\n                    University, Shanghai, China"},{"name":"Department of Hematology, The Affiliated People\u02bcs Hospital of Ningbo\n                    University, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated People\u02bcs Hospital of Ningbo\n                    University, Ningbo, China"},{"name":"Institute of Hematology, Ningbo University, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated People\u02bcs Hospital of Ningbo\n                    University, Ningbo, China"},{"name":"Institute of Hematology, Ningbo University, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Sha","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated People\u02bcs Hospital of Ningbo\n                    University, Ningbo, China"},{"name":"Institute of Hematology, Ningbo University, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2960-3131","authenticated-orcid":false,"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated People\u02bcs Hospital of Ningbo\n                    University, Ningbo, China"},{"name":"Institute of Hematology, Ningbo University, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S0140-6736(25)00864-5","article-title":"Acute lymphocytic leukaemia","volume":"406","author":"H Kantarjian","year":"2025","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1200\/JCO.23.00088","article-title":"Outcome for children and young adults with T-cell all and induction failure in\n                    contemporary 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Hongzhi","year":"2022","journal-title":"Animal Model Exp Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"111044","DOI":"10.1016\/j.biopha.2020.111044","article-title":"Anticancer activities of TCM and their active components against tumor\n                    metastasis","volume":"133","author":"K Wang","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1142\/S0192415X14500359","article-title":"Traditional Chinese medicine: A treasured natural resource of anticancer drug\n                    research and development","volume":"42","author":"C Y Wang","year":"2014","journal-title":"Am J Chin Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.2174\/0109298673319496240911060138","article-title":"Vincristine in cancer therapy: Mechanisms, efficacy, and future\n                    perspectives","volume":"32","author":"N Garg","year":"2025","journal-title":"Curr Med 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