{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:02:54Z","timestamp":1791511374594,"version":"4.3.4"},"reference-count":137,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die S3-Leitlinie beschreibt evidenz- und konsensbasierte Empfehlungen zur strukturierten Nachsorge erwachsener Patient*innen nach Lungentransplantation. Ziel ist die Standardisierung der Langzeitbetreuung zur Optimierung von \u00dcberleben, Funktionsstatus und Lebensqualit\u00e4t. Die Leitlinie richtet sich an pneumologische, internistische, chirurgische und haus\u00e4rztliche Fachkreise sowie an Transplantationszentren und station\u00e4re Einrichtungen in den deutschsprachigen L\u00e4ndern Deutschland, \u00d6sterreich und der Schweiz. Die Federf\u00fchrung hat die Deutsche Gesellschaft f\u00fcr Pneumologie und Beatmungsmedizin e.\u200aV. (DGP).<\/jats:p>\n                  <jats:p>Methodisch basiert sie auf systematischen Literaturrecherchen und GRADE-basierter Evidenzbewertung; und der Entwicklung eines interdisziplin\u00e4r und multiprofessionellen Konsens unter Beteiligung von Patientenvertretern.<\/jats:p>\n                  <jats:p>Die Leitlinie betont ein lebenslanges, individualisiertes Nachsorgekonzept, das auf enger Kooperation zwischen Transplantationszentrum, niedergelassenen \u00c4rztinnen und Patientinnen beruht. Zentrale Inhalte der Leitlinie umfassen die Immunsuppression mit Auswahl, Kombination und Monitoring von Calcineurininhibitoren, Antimetaboliten und mTOR-Inhibitoren. Au\u00dferdem ber\u00fccksichtigt sie Strategien zur Minimierung von Nebenwirkungen und Nephrotoxizit\u00e4t. Kerngebiete sind auch die Vorbeugung und Behandlung von Infektionen wie die Pr\u00e4vention opportunistischer Infektionen (CMV, Aspergillus, Pneumocystis jirovecii u.\u200aa.) und zur Impfstrategie. Die Leitlinie gibt Empfehlung zur standardisierten \u00dcberwachung von Patienten mittels Bronchoskopien, Biopsien und Spirometrie mit strukturierten Visitenintervallen eines Nachsorgekonzeptes inklusive Vorsorgeuntersuchungen. Die Themen akuter zellul\u00e4rer Absto\u00dfung, mangelnde Therapietreue und chronisches Transplantatversagen werden ebenfalls behandelt. Komorbidit\u00e4ten wie Diabetes, chronische Nierenkrankheit, Osteoporose und Tumorpr\u00e4vention werden ebenfalls ber\u00fccksichtigt.<\/jats:p>","DOI":"10.1055\/a-2817-1499","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:46:42Z","timestamp":1773445602000},"page":"234-270","source":"Crossref","is-referenced-by-count":2,"title":["Nachsorge von Erwachsenen nach Lungentransplantation"],"prefix":"10.1055","volume":"80","author":[{"given":"Jens","family":"Gottlieb","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pneumologie und Infektiologie, Medizinische Hochschule Hannover, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Wald","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Leipzig, Abteilung Pneumologie, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Bucher","sequence":"additional","affiliation":[{"name":"Tirol Kliniken (Pneumologie\/Transplantationsnachsorge) Innsbruck, \u00d6sterreich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Tapp","sequence":"additional","affiliation":[{"name":"Bundesverband der Organtransplantierten e.\u200aV. 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