{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:24:14Z","timestamp":1787268254745,"version":"build-2736575974"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","award":["APQ-01680-23"],"award-info":[{"award-number":["APQ-01680-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013275","name":"Instituto Serrapilheira","doi-asserted-by":"crossref","award":["APQ-05839-23 091\/2023 - Chamada de Apoio a Jovens"],"award-info":[{"award-number":["APQ-05839-23 091\/2023 - Chamada de Apoio a Jovens"]}],"id":[{"id":"10.13039\/501100013275","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de amparo \u00e0 pesquisa do Estado de S\u00e3o Paulo","award":["21\/05584-7, 23\/14219-6, and 21\/15122-0"],"award-info":[{"award-number":["21\/05584-7, 23\/14219-6, and 21\/15122-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Previous studies have highlighted the effects of lemongrass essential oil (Cymbopogon citratus) on the cardiovascular system, particularly its hypotensive and vasodilatory properties. Given the heart\u02bcs crucial role in blood pressure regulation, this study aimed to investigate the impact of lemongrass essential oil (EOCC) on cardiac excitation-contraction coupling and voltage-gated ion channel currents. Chemical analysis of EOCC, conducted through gas chromatography\u2013mass spectrometry, identified geranial (39.9%) and neral (27.4%) as the primary components. The effect of EOCC on cardiac contractility was assessed using isolated guinea pig atria. The results showed that EOCC decreased both the contraction amplitude and the frequency of spontaneous atrial contraction in a concentration-dependent manner (IC50 values of 106.8\u2009\u00b5g\/mL, 95% CI=78.9 to 133\u2009\u00b5g\/mL and 258.4\u2009\u00b5g\/mL, 95% CI=202.7 to 443.2\u2009\u00b5g\/mL n\u2009=\u20095\u200a\u2013\u200a8, respectively). Notably, EOCC exhibited arrhythmogenic activity, since it induced spontaneous contractions in isolated atrial preparations. Additionally, in an arrhythmia model induced by ouabain, EOCC significantly reduced the time to arrhythmia onset by 67.8% (n\u2009=\u20094). To further explore the mechanisms of the essential oil in atrial excitability, we employed the patch-clamp technique on isolated ventricular cardiomyocytes to examine EOCC\u02bcs effects on the L-type calcium current (ICa-L). The human embryonic kidney cell line (HEK293) transiently expressing human NaV\u20091.5 was used to study the effects on cardiac sodium currents (INa). EOCC reduced the peak amplitude of both INa and ICa-L in a concentration- and voltage-dependent manner, with IC50 values of 299.7\u2009\u00b5g\/mL (95% CI=241.5 to 358\u2009\u00b5g\/mL, n\u2009=\u20096\u200a\u2013\u200a7) for INa and 132.8\u2009\u00b5g\/mL (95% CI=71 to 173.8, n\u2009=\u20099) for ICa-L. In conclusion, the negative inotropic of EOCC may significantly contribute to its hypotensive effects. However, the association of relatively low concentrations of EOCC with cardiac arrhythmias raises concerns about its medicinal use.<\/jats:p>","DOI":"10.1055\/a-2817-4124","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:53:47Z","timestamp":1774482827000},"page":"980-992","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Lemongrass Essential Oil Cymbopogon citratus on the Contractility and Electrical Activity of the Guinea Pig Heart"],"prefix":"10.1055","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-2062","authenticated-orcid":false,"given":"Grazielle Ribeiro de Queiroz","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biof\u00edsica e Farmacologia do Cora\u00e7\u00e3o, Departamento de Educa\u00e7\u00e3o (Campus XII), Universidade do Estado da Bahia (UNEB), Guanambi, Bahia, Brazil"},{"name":"Departamento de Ci\u00eancias da Vida (Campus I), Universidade do Estado da Bahia (UNEB), Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-4667","authenticated-orcid":false,"given":"Thalyan Oliveira","family":"Malheiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biof\u00edsica e Farmacologia do Cora\u00e7\u00e3o, Departamento de Educa\u00e7\u00e3o (Campus XII), Universidade do Estado da Bahia (UNEB), Guanambi, Bahia, Brazil"},{"name":"Departamento de Ci\u00eancias da Vida (Campus I), Universidade do Estado da Bahia (UNEB), Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leisiane Pereira","family":"Marques","sequence":"additional","affiliation":[{"name":"Departamento de Biof\u00edsica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"},{"name":"Laborat\u00f3rio de CardioBiologia, Departamento de Biof\u00edsica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana da Silva","family":"Alc\u00e2ntara","sequence":"additional","affiliation":[{"name":"Departamento de Biof\u00edsica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"},{"name":"Laborat\u00f3rio de CardioBiologia, Departamento de Biof\u00edsica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Lobo de Sousa","family":"Marques","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiologia Cardiovascular, Departamento de Fisiologia e Biof\u00edsica do Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maycon Douglas","family":"Marques","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioqu\u00edmica e Imunologia da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Roman-Campos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de CardioBiologia, Departamento de Biof\u00edsica, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Santos-Miranda","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiologia Cardiovascular, Departamento de Fisiologia e Biof\u00edsica do Instituto de Ci\u00eancias Biol\u00f3gicas da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Marcos Teixeira de Alencar","family":"Filho","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Bromatol\u00f3gicas, na Faculdade de Farm\u00e1cia da Universidade Federal da Bahia (UFBA), Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-8480","authenticated-orcid":false,"given":"Antonio Nei Santana","family":"Gondim","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biof\u00edsica e Farmacologia do Cora\u00e7\u00e3o, Departamento de Educa\u00e7\u00e3o (Campus XII), Universidade do Estado da Bahia (UNEB), Guanambi, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1590\/S0102-695X2010005000012","article-title":"Chemical composition and cardiovascular effects induced by the essential oil of Cymbopogon citratus DC. 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