{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:08:16Z","timestamp":1789081696914,"version":"build-2803163510"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"name":"National Science Center","award":["2020\/39\/D\/NZ7\/01824"],"award-info":[{"award-number":["2020\/39\/D\/NZ7\/01824"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Japanese pearl tree (Styphnolobium japonicum), an ornamental species\n                    native to East Asia, has long been valued in traditional Chinese medicine and is\n                    now gaining renewed attention for its multifaceted pharmacological potential.\n                    This review synthesizes the current knowledge of its bioactive compounds,\n                    particularly flavonoids such as genistein, rutoside, quercetin, and\n                    sophoricoside, and their broad-spectrum biological activities, including\n                    antioxidant, anti-inflammatory, antimicrobial, neuroprotective, and\n                    wound-healing effects. These phytochemicals contribute to protective mechanisms\n                    against oxidative stress, skin photoaging, osteoporosis, cardiovascular\n                    dysfunction, and metabolic disorders such as diabetes and obesity. Emerging\n                    evidence also supports their role in managing neurodegenerative and inflammatory\n                    diseases, alopecia, and postmenopausal symptoms. Despite its promise, the\n                    clinical translation of S. japonicum remains limited by gaps in safety,\n                    pharmacokinetic characterization, and standardized extraction protocols. Looking\n                    ahead, integrative approaches combining phytochemistry, pharmacogenomics, and\n                    advanced biotechnology are expected to unlock its full therapeutic potential. By\n                    bridging traditional use with precision medicine and sustainable bioprocessing,\n                        S. japonicum stands as a prospective source of next-generation\n                    plant-based therapeutics for modern healthcare.<\/jats:p>","DOI":"10.1055\/a-2817-4235","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T22:58:50Z","timestamp":1775775530000},"page":"996-1007","source":"Crossref","is-referenced-by-count":0,"title":["Japanese Pearl Tree (Styphnolobium japonicum): An Exploration\n                    of Its Health Benefits"],"prefix":"10.1055","volume":"92","author":[{"given":"Magdalena","family":"Paczkowska-Walendowska","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biomaterials, Poznan University of\n                    Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzanna","family":"Rybarczyk","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biomaterials, Poznan University of\n                    Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Raniszewska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Studzi\u0144ska-Sroka","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biomaterials, Poznan University of\n                    Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judyta","family":"Cielecka-Piontek","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biomaterials, Poznan University of\n                    Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.3390\/genes14061156","article-title":"Intraspecific chloroplast genome variation and domestication origins of major\n                    cultivars of Styphnolobium japonicum","volume":"14","author":"Z Mu","year":"2023","journal-title":"Genes (Basel)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"102479","DOI":"10.1016\/j.mex.2023.102479","article-title":"A green method to extract rutin from Sophora japonica L","volume":"11","author":"N T Le","year":"2023","journal-title":"MethodsX"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jep.2016.04.014","article-title":"Local and traditional uses, phytochemistry, and pharmacology of Sophora\n                        japonica L.: A review","volume":"187","author":"X He","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1002\/fft2.367","article-title":"Sophora japonica L. bioactives: Chemistry, sources, and processing\n                    techniques","volume":"5","author":"N Guo","year":"2024","journal-title":"Food Frontiers"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpls.2023.1255637","article-title":"Combined analysis of inorganic elements and flavonoid metabolites reveals the\n                    relationship between flower quality and maturity of Sophora japonica\n                    L","volume":"14","author":"T W Wang","year":"2023","journal-title":"Front Plant Sci"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"8932","DOI":"10.3390\/molecules27248932","article-title":"Nutritional attributes and phenolic composition of flower and bud of Sophora\n                        japonica L. and Robinia pseudoacacia L","volume":"27","author":"J Tian","year":"2022","journal-title":"Molecules"},{"key":"ref7","first-page":"39","article-title":"Genistein and daidzein: Different molecular effects on prostate cancer","volume":"33","author":"M Adjakly","year":"2013","journal-title":"Anticancer Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/S0955-2863(00)00085-1","article-title":"Daidzein and genistein content of fruits and nuts","volume":"11","author":"J Liggins","year":"2000","journal-title":"J Nutr Biochem"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.3390\/molecules25081767","article-title":"Optimization of ultrasound-assisted extraction using response surface\n                    methodology for simultaneous quantitation of six flavonoids in Flos Sophorae\n                    immaturus and antioxidant activity","volume":"25","author":"S Fan","year":"2020","journal-title":"Molecules"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.3390\/molecules24142633","article-title":"Styphnolobium japonicum (L.) 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