{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:16:15Z","timestamp":1781075775704,"version":"3.54.1"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Endotools, Brussels, Belgium"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent international guidelines (American Society for Gastrointestinal Endoscopy and European Society of Gastrointestinal Endoscopy) suggest endoscopic treatment plus lifestyle management for management of obesity class I and II. The aim of this prospective study was to assess results of Endosleeve gastroplasty (ESG) plus lifestyle management (LSM).<\/jats:p>\n                  <jats:p>Twenty-nine patients (mean age 44 years) were included in a longitudinal prospective cohort study in two experienced centers. Mean weight at inclusion was 91.13 kg (\u00b1 8.4) and mean body mass index (BMI) was 34.08 (\u00b1 2.43) kg\/m2. ESG was performed using Endomina (Endo Tools Therapeutics S.A., Gosselies, Belgium) 6 months after LSM and patients were followed for 1 year with continuous LSM.<\/jats:p>\n                  <jats:p>Twenty-eight patients completed 12-month follow-up. Total body weight loss (TBWL) was 11.05% (P &lt; 0.001, 81.2% of cases with TBWL decrease &gt; 5 %). EWL was significantly reached in 40.98% (P &lt; 0.001). Final BMI was significantly decreased (30.52 kg\/m2; P &lt; 0.001). Glucose control and HbA1c level were significantly improved at 1 year (P = 0.01 and P = 0.003). Liver function tests (gamma-glutamyl transferase, alanine aminotransferase) were significantly decreased (P = 0.006 and P = 0.009). Diastolic arterial pressure significantly decreased at 1 year (P &lt; 0.001). Quality of life (QoL) score (sf12) for physical activity was significantly improved (P = 0.05). Only one adverse event was noted (sustained pain; AGREE II). No nutritional deficiency assessed by biological measurements appeared during follow-up.<\/jats:p>\n                  <jats:p>ESG combined with LSM resulted in significant improvement in TBWL, EWL, BMI, and QoL. Metabolic improvements were also observed without leading to nutritional deficiency.<\/jats:p>","DOI":"10.1055\/a-2819-0356","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:39:37Z","timestamp":1772066377000},"source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Endoscopic sleeve gastroplasty: Prospective assessment of weight loss and metabolic impact"],"prefix":"10.1055","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct03900481","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Marc","family":"Barthet","sequence":"additional","affiliation":[{"name":"Gastroenterology, H\u00f4pital Nord, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-9076","authenticated-orcid":false,"given":"Geoffroy","family":"Vanbiervliet","sequence":"additional","affiliation":[{"name":"P\u00f4le digestif, H\u00f4pital de L'Archet 2, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-8236","authenticated-orcid":false,"given":"Jean-Michel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Gastroenterology, H\u00f4pital Nord, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Thobois","sequence":"additional","affiliation":[{"name":"Gastroenterology, CHU Nice, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Poher","sequence":"additional","affiliation":[{"name":"H\u00f4pital Nord, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Blin","sequence":"additional","affiliation":[{"name":"H\u00f4pital Nord, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shani","family":"Diai","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9 Facult\u00e9 de 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