{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:34:36Z","timestamp":1777073676774,"version":"3.51.4"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ulnar compression neuropathy is the second most frequent entrapment neuropathy of\n                    the upper extremity and is observed with increased prevalence among diabetes\n                    mellitus patients. The metabolic burden of diabetes mellitus, including chronic\n                    hyperglycaemia, microvascular dysfunction, and systemic inflammation, promotes\n                    nerve susceptibility to mechanical compression. This review summarises current\n                    evidence on the association between diabetes mellitus and ulnar compression\n                    neuropathy, highlighting epidemiological data, metabolic contributors, clinical\n                    manifestations, diagnostic tools, and management strategies. Diagnostic\n                    evaluation in diabetes mellitus patients may be challenging due to coexisting\n                    polyneuropathy, necessitating a multimodal and individualized approach.\n                    Management strategies include both conservative measures and surgical\n                    decompression, with early intervention being critical to prevent permanent\n                    deficits. Clinicians should maintain high suspicion of ulnar compression\n                    neuropathy in diabetes mellitus patients to ensure timely diagnosis and improve\n                    functional outcomes in this high-risk population.<\/jats:p>","DOI":"10.1055\/a-2821-0169","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:40:13Z","timestamp":1772066413000},"page":"124-128","source":"Crossref","is-referenced-by-count":0,"title":["Diabetic Ulnar Compression Neuropathy"],"prefix":"10.1055","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6458-8201","authenticated-orcid":false,"given":"Iliana","family":"Stamatiou","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Second Department of Internal\n                    Medicine, Democritus University of Thrace-Alexandropoulis Campus,\n                    Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-785X","authenticated-orcid":false,"given":"Nikolaos","family":"Papanas","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Second Department of Internal\n                    Medicine, Democritus University of Thrace-Alexandropoulis Campus,\n                    Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/neuros\/nyw061","article-title":"Cubital tunnel syndrome: incidence and demographics in a national administrative\n                    database","volume":"80","author":"D A Osei","year":"2017","journal-title":"Neurosurgery"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e010921196025","DOI":"10.2174\/1573399817666210901114610","article-title":"Carpal tunnel syndrome 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enigma","volume":"16","author":"K Sugimoto","year":"2000","journal-title":"DiabetesMetab Res Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12902-021-00697-7","article-title":"Skin AGEs and diabetic neuropathy","volume":"21","author":"S Papachristou","year":"2021","journal-title":"BMC Endocr Disord"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1056\/NEJM196807042790104","article-title":"Ischemic mononeuropathy and mononeuropathy multiplex in diabetes mellitus","volume":"279","author":"M C Raff","year":"1968","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.jhsa.2010.01.007","article-title":"Compressive neuropathies of the upper extremity: Update on pathophysiology,\n                    classification, and electrodiagnostic findings","volume":"35","author":"M Tapadia","year":"2010","journal-title":"J Hand Surg Am"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/j.1365-2990.1986.tb00159.x","article-title":"Chronic human nerve compression\u2014a histological assessment","volume":"12","author":"S E Mackinnon","year":"1986","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0022-510x(84)90037-6","article-title":"Long-term remyelination fails to reconstitute normal thickness of central myelin\n                    sheaths","volume":"64","author":"S K Ludwin","year":"1984","journal-title":"J Neurol Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nrn2294","article-title":"Glucose neurotoxicity","volume":"9","author":"D R Tomlinson","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"ref19","first-page":"278","article-title":"Ulnar neuropathy at the elbow in diabetes","volume":"88","author":"M Mondelli","year":"2009","journal-title":"AmJPhysMedRehab"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1097\/PHM.0b013e318190b89d","article-title":"The metabolic syndrome and neuropathy: Therapeutic challenges and\n                    opportunities","volume":"74","author":"B Callaghan","year":"2013","journal-title":"Ann Neurol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1007\/s00125-019-4959-1","article-title":"New insights into the mechanisms of diabetic complications: Role of lipids and\n                    lipid metabolism","volume":"62","author":"S Eid","year":"2019","journal-title":"Diabetologia"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"9450","DOI":"10.1038\/s41598-019-45675-1","article-title":"Smoking is associated with ulnar nerve entrapment: A birth cohort study","volume":"9","author":"S Hulkkonen","year":"2019","journal-title":"Sci 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