{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:40:16Z","timestamp":1782470416588,"version":"3.54.5"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012401","name":"Beijing Science and Technology Planning Project","doi-asserted-by":"crossref","award":["Z221100007422079"],"award-info":[{"award-number":["Z221100007422079"]}],"id":[{"id":"10.13039\/501100012401","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Research regarding utilization of capsule endoscopy for detecting early esophageal squamous cell carcinoma (ESCC) is limited. This study was designed to preliminarily explore diagnostic performance of magnetically controlled capsule endoscopy with a detachable string (DS-MCCE) for detecting early ESCC.<\/jats:p>\n                  <jats:p>In this retrospective cross-sectional diagnostic study, 496 asymptomatic individuals with high-risk lesions suspicious for early ESCC in esophagus, suspected neoplastic gastric and duodenal lesions, and all ulcers in the upper gastrointestinal tract first underwent DS-MCCE followed by esophagogastroduodenoscopy (EGD) and biopsy within 1 week. Outcomes included diagnostic performance of DS-MCCE for esophageal mucosal lesions and early ESCC, examination time, patient comfort and preference, and safety.<\/jats:p>\n                  <jats:p>DS-MCCE had a sensitivity of 95.36 % (95% confidence interval [CI] 90.32%-97.95%) and specificity of 88.99% (85.08%-91.99%) for detecting esophageal mucosal lesions, whereas for detecting early ESCC, it showed a sensitivity of 66.67% (95% CI 38.38%-88.18%) and specificity of 99.17% (95% CI 97.88%-99.77%). DS-MCCE demonstrated superiority to EGD without sedation in terms of patient comfort, and participants preferred DS-MCCE to EGD. Median examination time was 9.1 minutes. There were no adverse events associated with DS-MCCE.<\/jats:p>\n                  <jats:p>DS-MCCE has potential in detecting early ESCC, mainly for lesions that are larger in size or exhibit pronounced morphological features. These preliminary findings support a further large-sample prospective study and technical refinement.<\/jats:p>","DOI":"10.1055\/a-2823-7782","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:03:37Z","timestamp":1773273817000},"source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Exploratory evaluation of magnetic capsule endoscopy with detachable-string for detecting esophageal lesions including early squamous cell carcinoma"],"prefix":"10.1055","volume":"14","author":[{"given":"Haowen","family":"Dai","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing, China"},{"name":"Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing, China"},{"name":"Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Sun","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Chinese PLA General Hospital, Department of Gastroenterology and Hepatology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3411-4602","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghui","family":"Duan","sequence":"additional","affiliation":[{"name":"Senior Department of Gastroenterology, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Chinese PLA General Hospital, Department of Gastroenterology and Hepatology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Xu","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Chinese PLA General Hospital, Department of Gastroenterology and Hepatology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6685-1906","authenticated-orcid":false,"given":"Peng","family":"Jin","sequence":"additional","affiliation":[{"name":"Senior Department of Gastroenterology, Chinese PLA General Hospital, Beijing, China"},{"name":"Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiu","family":"Sheng","sequence":"additional","affiliation":[{"name":"Senior Department of Gastroenterology, Chinese PLA General Hospital, Beijing, China"},{"name":"Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China"},{"name":"Medical School of Chinese PLA, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"RL Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1053\/j.gastro.2022.05.054","article-title":"The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: New estimates from GLOBOCAN 2020","volume":"163","author":"E 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