{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:50:22Z","timestamp":1773449422650,"version":"3.50.1"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":71,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg Rep"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to contribute to the sparse literature on middle ear neuroendocrine tumors (MeNETs) by detailing a unique case of MeNET-associated cochlear\u2013vestibular dysfunction and outlining diagnostic, therapeutic, and follow-up considerations.<\/jats:p>\n                  <jats:p>A single-patient case report.<\/jats:p>\n                  <jats:p>A tertiary academic referral center.<\/jats:p>\n                  <jats:p>A 40-year-old male presenting with profound left sensorineural hearing loss (SNHL), left vestibular hypofunction, and a middle ear mass.<\/jats:p>\n                  <jats:p>Histopathologic confirmation of MeNET, radiological identification of residual disease, postoperative symptom progression, and rehabilitation outcome.<\/jats:p>\n                  <jats:p>Clinical evaluation, imaging, and histopathology confirmed the diagnosis of MeNET. Immunohistochemistry revealed positivity for chromogranin, synaptophysin, insulinoma-associated protein 1 (INSM1), cytokeratin mouse monoclonal antibody (CAM 5.2). An endoscopic middle ear exploration with tympanoplasty and canalplasty was performed, followed by vestibular rehabilitation. Surveillance with DOTA-Tyr3-octreotate PET\/MRI identified residual disease, leading to a revision mastoidectomy. The patient experienced persistent imbalance postoperatively, requiring vestibular rehabilitation, and profound SNHL, for which a hearing aid evaluation was recommended.<\/jats:p>\n                  <jats:p>This case represents the first report of MeNET-associated cochlear\u2013vestibular dysfunction. The significance of this report lies in the unique clinical presentation, the role of advanced imaging for surveillance, and the need for revision mastoidectomy following an initial endoscopic approach. This report discusses the challenges in achieving complete tumor clearance and emphasizes the need for continued case documentation and research into adjunctive therapies.<\/jats:p>","DOI":"10.1055\/a-2823-9080","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:01:22Z","timestamp":1773446482000},"page":"e41-e45","source":"Crossref","is-referenced-by-count":0,"title":["Vestibular Dysfunction as a Novel Presentation of Middle Ear Neuroendocrine Tumor"],"prefix":"10.1055","volume":"87","author":[{"given":"Amor","family":"Niksic","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rance JT","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Isaacson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s12105-018-0924-4","article-title":"Neuroendocrine neoplasms of the ear","volume":"12","author":"N Katabi","year":"2018","journal-title":"Head Neck Pathol"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"e712","DOI":"10.1097\/MAO.0000000000001905","article-title":"Adenomatous neuroendocrine tumors of the middle ear: A multi-institutional investigation of 32 cases and development of a staging system","volume":"39","author":"J P Marinelli","year":"2018","journal-title":"Otol Neurotol"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1038\/s41379-018-0110-y","article-title":"A common classification framework for neuroendocrine neoplasms: An International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal","volume":"31","author":"G Rindi","year":"2018","journal-title":"Mod Pathol"},{"issue":"09","key":"ref4","first-page":"3453","article-title":"Neuroendocrine neoplasms of the middle ear: Report of 2 cases and review of the literature","volume":"12","author":"S He","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"issue":"09","key":"ref5","doi-asserted-by":"crossref","first-page":"e13031","DOI":"10.1111\/jne.13031","article-title":"Middle ear neuroendocrine tumours: Insight into their pathogenesis, diagnosis and management","volume":"33","author":"G M Ratnayake","year":"2021","journal-title":"J Neuroendocrinol"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"e1677","DOI":"10.1097\/MAO.0000000000003234","article-title":"Endoscopic management of early stage middle ear paragangliomas - 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A review of its use in treating neuroendocrine tumours","volume":"10","author":"F Costa","year":"2014","journal-title":"Eur Endocrinol"},{"key":"ref11","first-page":"20","article-title":"Treatment with somatostatin analogues and PRRT in metastatic middle ear adenoma with neuroendocrine features","volume":"2021","author":"J Lima Ferreira","year":"2021","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/lary.27343","article-title":"Pathophysiology of sensorineural hearing loss in jugular foramen paraganglioma","volume":"129","author":"B Isaacson","year":"2019","journal-title":"Laryngoscope"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1111\/ene.15051","article-title":"Labyrinthine haemorrhage secondary to cerebral venous thrombosis","volume":"28","author":"A I Martins","year":"2021","journal-title":"Eur J Neurol"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1034\/j.1600-0404.2001.104002068.x","article-title":"Evidences of vascular origin of cochleovestibular dysfunction","volume":"104","author":"A Szirmai","year":"2001","journal-title":"Acta Neurol Scand"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/00016489.2021.2014071","article-title":"Examination of risk factors for postoperative vestibular symptoms in patients with cholesteatoma","volume":"142","author":"T Kobayashi","year":"2022","journal-title":"Acta Otolaryngol"}],"container-title":["Journal of Neurological Surgery Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2823-9080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:01:24Z","timestamp":1773446484000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2823-9080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,1,12]]},"published-print":{"date-parts":[[2026,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2823-9080","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6358","2193-6366"],"issn-type":[{"value":"2193-6358","type":"print"},{"value":"2193-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}