{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:57:17Z","timestamp":1775606237080,"version":"3.50.1"},"reference-count":69,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"Pediatric Oncology and Hematology UNiversity Hospital Homburg Saar","award":["Third-party funding for conducting clinical resear"],"award-info":[{"award-number":["Third-party funding for conducting clinical resear"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die station\u00e4re Therapie der RSV-Infektion umfasst nicht evidenzbasierte Ma\u00dfnahmen einschlie\u00dflich einer \u00dcbertherapie mit Antibiotika. Durch die Einf\u00fchrung von Nirsevimab als passive Immunisierung soll die Anzahl station\u00e4r behandelter S\u00e4uglinge abnehmen.<\/jats:p>\n                  <jats:p>Kann in einem regionalen p\u00e4diatrisch-infektiologischen Netzwerk die station\u00e4re Therapie der RSV-Infektion verbessert werden? Wirkt sich die Einf\u00fchrung des Nirsevimab auf die station\u00e4re Epidemiologie aus?<\/jats:p>\n                  <jats:p>Prospektive Studie (2024\/2025) in sechs Kinderkliniken einer Region. Vereinbarung eines Behandlungsstandards einschlie\u00dflich von f\u00fcnf Interventionen, die eher unterlassen werden sollten (Leave 5). Analyse der Epidemiologie (\u226424 Mo und 25\u201336 Mo) 2022\u20132025.<\/jats:p>\n                  <jats:p>121 Clinical Review Forms (CRF) wurden erfasst. 101 (83,5%) der Patienten waren\u226424 Monate alt. Die Liegedauer betrug 4\u00b13 Tage vs. 3,5\u00b12 Tage (\u226424 Mo vs. 25\u201336 Mo). Mindestens ein Risikofaktor war bei 24% (\u226424 Mo) und 25% (25\u201336 Mo; p=0,8) dokumentiert. In 56% der F\u00e4lle wurden alle f\u00fcnf Leave 5-Ma\u00dfnahmen vermieden (\u226424 Monate 58%, 25-36 Monate 45%). Bei den Patienten\u226424 Mo erhielten nur 9% Antibiotika. Nach Einf\u00fchrung von Nirsevimab kam es zu einer Abnahme der station\u00e4ren RSV-Behandlungsf\u00e4llen\u226424 Mo (\u00fcber 60%; p&lt;0,0001).<\/jats:p>\n                  <jats:p>Eine Evidenz-basierte, vorwiegend supportive Therapie der RSV-Infektion bei station\u00e4r behandelten Kindern\u226424 Mo kann durch ein abgestimmtes Vorgehen in einem p\u00e4diatrisch-infektiologischen Netzwerk gef\u00f6rdert werden. Bereits kurz nach der Einf\u00fchrung des Nirsevimab zeigt sich ein deutlicher Effekt auf die station\u00e4re Epidemiologie.<\/jats:p>","DOI":"10.1055\/a-2826-9348","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:24:02Z","timestamp":1775604242000},"source":"Crossref","is-referenced-by-count":0,"title":["Station\u00e4re Therapie von RSV-infizierten Kindern (Leave 5) und fr\u00fche Effekte des Nirsevimab in einem regionalen p\u00e4diatrisch-infektiologischen Netzwerk"],"prefix":"10.1055","author":[{"given":"Katharina","family":"Remke","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische Pneumologie, Allgemeine P\u00e4diatrie und Neonatologie, Kinderklinik am Universit\u00e4tsklinikum des Saarlandes, UKS, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics and Neonatology, Saarland University Medical School, Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-7419","authenticated-orcid":false,"given":"Michael","family":"Zemlin","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische Pneumologie, Allgemeine P\u00e4diatrie und Neonatologie, Kinderklinik am Universit\u00e4tsklinikum des Saarlandes, UKS, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3575-4999","authenticated-orcid":false,"given":"Marie-Claire","family":"Detemple","sequence":"additional","affiliation":[{"name":"Kinderklinik am Klinikum Winterberg, Saarbrucken Hospital, Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Ghiath","family":"Shamdeen","sequence":"additional","affiliation":[{"name":"Kinder- und Jugendmedizin, Marienhausklinik Sankt Josef Kohlhof, Neunkirchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Drautz","sequence":"additional","affiliation":[{"name":"Kinder- und Jugendmedizin, Marienhausklinik Sankt Josef Kohlhof, Neunkirchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Thomas","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Kinder- und Jugendmedizin, Klinikum Mutterhaus der Borrom\u00e4erinnen gGmbH, Trier, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Kinder- und Jugendmedizin, Klinikum Mutterhaus der Borrom\u00e4erinnen gGmbH, Trier, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven Thorsten","family":"Nipken","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr P\u00e4diatrie, Klinkum Idar-Oberstein GmbH, Idar-Oberstein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"de la Rosa-Ramos","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr P\u00e4diatrie, Klinkum Idar-Oberstein GmbH, Idar-Oberstein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Berger","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, UKS, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Picard","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische Onkologie und H\u00e4matologie, Kinderklinik am Universit\u00e4tsklinikum des Saarlandes, UKS, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-3330","authenticated-orcid":false,"given":"Arne","family":"Simon","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische Onkologie und H\u00e4matologie, Kinderklinik am Universit\u00e4tsklinikum des Saarlandes, UKS, Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"ref1","first-page":"6","article-title":"Respiratory syncytial virus: diagnosis, prevention and management","author":"R Barr","year":"2019","journal-title":"Ther Adv Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e247125","DOI":"10.1001\/jamanetworkopen.2024.7125","article-title":"Respiratory Syncytial Virus Hospital-Based Burden of Disease in Children Younger Than 5 Years, 2015\u20132022","volume":"7","author":"R J Suss","year":"2024","journal-title":"JAMA Netw 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