{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:16:50Z","timestamp":1782947810872,"version":"3.54.5"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>An\u00e4mie ist eine h\u00e4ufige Komplikation bei Katzen mit chronischer Nierenerkrankung\n(chronic kidney disease, CKD), haupts\u00e4chlich aufgrund einer verminderten\nProduktion von Erythropoetin (EPO), die aus einem Verlust von renalen\nErythropoetin-produzierenden (REP) Zellen resultiert. An\u00e4mie beeinflusst sowohl\ndas \u00dcberleben als auch die Lebensqualit\u00e4t, indem sie klinische Symptome wie\nLethargie und Appetitlosigkeit hervorruft. Die fr\u00fchzeitige und regelm\u00e4\u00dfige\nH\u00e4matokrit-Bestimmung (Htk\/PCV) ist f\u00fcr eine Behandlungsentscheidung wichtig,\nbevor progressive Nierensch\u00e4den die therapeutische Wirksamkeit einschr\u00e4nken.\nMolidustat, ein Hypoxie-induzierbarer Faktor (HIF)-Prolylhydroxylase-Inhibitor\n(PHI), ist ein neues orales Medikament, das die endogene EPO-Synthese\nstimuliert. Die Behandlung sollte jedoch begonnen werden, wenn die REP-Zellen\nnoch funktionsf\u00e4hig sind, mit PCV-Zielwerten zwischen 30\u201340%. Eine regelm\u00e4\u00dfige\n\u00dcberwachung gem\u00e4\u00df den Richtlinien der International Renal Interest Society\n(IRIS) ist entscheidend, um den PCV-Wert innerhalb des Zielbereichs zu halten\nund zu bestimmen, wann die Behandlung begonnen, beendet oder wiederaufgenommen\nwerden sollte. Dar\u00fcber hinaus ist die \u00dcberwachung des Eisenstatus wichtig, da\nsowohl funktioneller als auch absoluter Eisenmangel bei Katzen mit CKD auftreten\nk\u00f6nnen und die Antwort auf die Behandlung beeintr\u00e4chtigen k\u00f6nnen.<\/jats:p>","DOI":"10.1055\/a-2827-1221","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T22:45:21Z","timestamp":1778193921000},"page":"187-192","source":"Crossref","is-referenced-by-count":0,"title":["Hypoxie-induzierbarer Faktor Prolylhydroxylase-Inhibitor als neue\nTherapieoption zur Behandlung der An\u00e4mie bei feliner chronischer\nNierenerkrankung"],"prefix":"10.1055","volume":"54","author":[{"given":"Andreas","family":"Moritz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Innere Medizin, Fachbereich Veterin\u00e4rmedizin,\nJustus-Liebig-Universit\u00e4t Gie\u00dfen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali Bettina","family":"Bauer","sequence":"additional","affiliation":[{"name":"Klinische Pathophysiologie und klinische Laboratoriumsdiagnostik,\nFachbereich Veterin\u00e4rmedizin, Justus-Liebig-Universit\u00e4t Gie\u00dfen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.jfms.2011.07.016","article-title":"Anemia of renal disease","volume":"13","author":"S Chalhoub","year":"2011","journal-title":"J Feline Med Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1939-1676.2004.tb00139.x","article-title":"Clinical efficacy and safety of recombinant canine erythropoietin in dogs with\nanemia of chronic renal failure and dogs with recombinant human\nerythropoietin-induced red cell aplasia","volume":"18","author":"J F Randolph","year":"2004","journal-title":"J Vet Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X251314769","article-title":"Owners\u2019 experiences of caring for cats with chronic kidney disease in the\nUK","volume":"27","author":"J Elliott","year":"2025","journal-title":"J Feline Med Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/jvp.13127","article-title":"Therapeutics of managing reduced red cell mass associated with chronic kidney\ndisease \u2013 Is there a case for earlier intervention?","volume":"46","author":"J Elliott","year":"2023","journal-title":"J Vet Pharmacol Ther"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1748-5827.1998.tb03598.x","article-title":"Feline chronic renal failure: clinical findings in 80 cases diagnosed between\n1992 and 1995","volume":"39","author":"J Elliott","year":"1998","journal-title":"J of Small Animal Practice"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.2460\/javma.1987.190.09.1196","article-title":"Clinicopathologic findings associated with chronic renal disease in cats: 74\ncases (1973\u20131984)","volume":"190","author":"S P DiBartola","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"ref7","first-page":"175","article-title":"Pathophysiology and management of anemia in chronic progressive renal\nfailure","volume":"7","author":"L D Cowgill","year":"1992","journal-title":"Semin Vet Med Surg (Small Anim)"},{"key":"ref8","first-page":"127","article-title":"Feline renal failure: questions, answers, questions","volume":"14","author":"J P Lulich","year":"1992","journal-title":"Compend Contin Educ Pract Vet"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fphys.2015.00167","article-title":"Renal erythropoietin-producing cells in health and disease","volume":"6","author":"T Souma","year":"2015","journal-title":"Front Physiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1093\/ndt\/16.suppl_7.36","article-title":"The role of inflammation in the anaemia of end-stage renal disease","volume":"16","author":"P Stenvinkel","year":"2001","journal-title":"Nephol Dial Transplant"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"127591","DOI":"10.1016\/j.jtemb.2025.127591","article-title":"Deciphering the role of hepcidin in iron metabolism and anemia management","volume":"87","author":"P Kesharwani","year":"2025","journal-title":"J Trace Elem Med Biol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092039","article-title":"Uremic toxins affect erythropoiesis during the course of chronic kidney disease:\nA review","volume":"9","author":"E Hamza","year":"2020","journal-title":"Cells"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1939-1676.2009.0339.x","article-title":"Evaluation of predictors of the development of azotemia in cats","volume":"23","author":"R E Jepson","year":"2009","journal-title":"J Vet Intern Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/j.1939-1676.2007.tb03042.x","article-title":"Prognostic factors in cats with chronic kidney disease","volume":"21","author":"J N King","year":"2007","journal-title":"J Vet Intern Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1111\/j.1939-1676.2008.0163.x","article-title":"Survival in cats with naturally occurring chronic kidney disease\n(2000\u20132002)","volume":"22","author":"L M Boyd","year":"2008","journal-title":"J Vet Intern Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1111\/jvim.13625","article-title":"Relationship 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Hypertens"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211005984","article-title":"Successful application of roxadustat in the treatment of\npatients with anti-erythropoietin antibody-mediated renal anaemia: a case report\nand literature review","volume":"49","author":"K-D Cai","year":"2021","journal-title":"J Int Med Res"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1296702","article-title":"Efficacy and safety of hypoxia-inducible factor-prolyl\nhydroxylase inhibitor treatment for anemia in chronic kidney disease: an\numbrella review of meta-analyses","volume":"14","author":"S Ren","year":"2023","journal-title":"Front\nPharmacol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/jvim.14661","article-title":"Acute-phase proteins and iron status in cats with chronic kidney disease","volume":"31","author":"R Javard","year":"2017","journal-title":"J Vet Intern 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Med"},{"key":"ref35","first-page":"250","article-title":"Iron deficiency anemia","volume":"53","author":"D Z Naigamwalla","year":"2012","journal-title":"Can Vet J"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.redox.2023.102950","article-title":"The effect of iron therapy on oxidative stress and intestinal microbiota in\ninflammatory bowel diseases: A review on the conundrum","volume":"68","author":"R Loveikyte","year":"2023","journal-title":"Redox Biol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/jcpt.13385","article-title":"Long-term efficacy and safety of hypoxia-inducible factor prolyl hydroxylase\ninhibitors in anaemia of chronic kidney disease: A meta-analysis including\n13,146 patients","volume":"46","author":"H H Chen","year":"2021","journal-title":"J Clin Pharm Ther"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122641","article-title":"The drug-specific properties of 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Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2827-1221.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:30:39Z","timestamp":1782945039000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2827-1221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":37,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,7,1]]},"published-print":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2827-1221","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"value":"1434-1239","type":"print"},{"value":"2567-5842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]}}}