{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:54:00Z","timestamp":1791845640609,"version":"4.3.4"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate whether maternal serum periostin levels measured in the second\ntrimester can serve as a biomarker for gestational diabetes mellitus (GDM)\nand predict perinatal outcomes.<\/jats:p>\n                  <jats:p>This prospective case\u2013control study included 173 pregnant women (103 with GDM\nand 70 healthy controls). Serum periostin levels were measured between 15\u201320\nweeks of gestation. GDM was diagnosed using a 75-g oral glucose tolerance\ntest at 24\u201328 weeks. Receiver operating characteristic (ROC) analysis and\nlogistic regression were used to evaluate diagnostic performance.<\/jats:p>\n                  <jats:p>Serum periostin levels were significantly higher in the GDM group compared to\ncontrols (median: 50.7 vs. 33.7 ng\/mL, p&lt;0.001). Periostin showed\nmoderate diagnostic accuracy for GDM (AUC: 0.752). Higher periostin levels\nwere associated with cesarean delivery, neonatal intensive care unit\nadmission, and meconium-stained amniotic fluid.<\/jats:p>\n                  <jats:p>Elevated maternal serum periostin levels in the second trimester are\nassociated with gestational diabetes msellitus and adverse perinatal\noutcomes. Periostin may serve as a supplementary biomarker for early\nidentification of GDM.<\/jats:p>","DOI":"10.1055\/a-2827-9333","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:17:07Z","timestamp":1774570627000},"page":"419-424","source":"Crossref","is-referenced-by-count":3,"title":["Maternal Serum Periostin as a Potential Biomarker for Gestational\nDiabetes Mellitus and Adverse Perinatal Outcomes"],"prefix":"10.1055","volume":"230","author":[{"given":"Semra","family":"Eroglu","sequence":"additional","affiliation":[{"name":"Obstetric and Gynecology, Samsun University Faculty of\nMedicine, Canik, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neset","family":"Gumusburun","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Istanbul Aydin University,\nIstanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebati Sinan","family":"Urkmez","sequence":"additional","affiliation":[{"name":"Biochemistry, Ondokuz Mayis University, Samsun,\nTurkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9662-244X","authenticated-orcid":false,"given":"Ye\u015fim","family":"Civil \u00dcrkmez","sequence":"additional","affiliation":[{"name":"Biochemistry, Ministry of Health Samsun Education and\nResearch Hospital, Ilkadim, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samettin","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Obstetric and Gynecology, Samsun University Faculty of\nMedicine, Canik, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fcbra","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Health Science, Samsun Provincial Health Directorate,\n\u0130lkad\u0131m, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.12688\/openreseurope.18026.1","article-title":"Gestational diabetes mellitus: unveiling maternal health dynamics from pregnancy\nthrough postpartum perspectives","volume":"4","author":"M Mora-Ortiz","year":"2024","journal-title":"Open Res Eur"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/endocrines2020007","article-title":"Exercise as a therapeutic intervention in gestational diabetes mellitus","volume":"2","author":"K Dipla","year":"2021","journal-title":"Endocrines"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S2213-8587(20)30161-3","article-title":"Gestational diabetes: opportunities for improving maternal and child health","volume":"8","author":"P Saravanan","year":"2020","journal-title":"Lancet Diabetes 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Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3390\/biom11081084","article-title":"Pathological roles and clinical usefulness of periostin in type 2 inflammation\nand pulmonary fibrosis","volume":"11","author":"J Ono","year":"2021","journal-title":"Biomolecules"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.3390\/ijms25042251","article-title":"The metabolic syndrome, a human disease","volume":"25","author":"M Alemany","year":"2024","journal-title":"Int J Mol Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1172\/JCI74438","article-title":"Periostin promotes liver steatosis and hypertriglyceridemia through\ndownregulation of PPAR\u03b1","volume":"124","author":"Y Lu","year":"2014","journal-title":"J Clin Invest"},{"key":"ref10","first-page":"6423637","article-title":"Plasma periostin levels are increased in Chinese subjects with\nobesity and type 2 diabetes and are positively correlated with 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PPAR\u03b1\/NF-\u03baB\/TNF-\u03b1\nsignaling pathway","volume":"23","author":"Q Ji","year":"2023","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4274\/tjod.galenos.2022.70593","article-title":"Evaluation of serum neopterin, periostin, tenascin-C, tissue inhibitor of\nmetalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant\nwomen","volume":"19","author":"R Meleko\u011flu","year":"2022","journal-title":"Turk J Obstet Gynecol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"103138","DOI":"10.1016\/j.jri.2020.103138","article-title":"Serum and placental periostin levels in women with early pregnancy loss","volume":"140","author":"S Eroglu","year":"2020","journal-title":"J Reprod Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"G194","DOI":"10.1152\/ajpgi.00413.2005","article-title":"Lipid metabolism and liver inflammation. 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Hepatic fatty acid uptake: possible\nrole in steatosis","volume":"290","author":"M W Bradbury","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12902-024-01693-3","article-title":"Association between mean platelet volume and the risk of type 2 diabetes\nmellitus among women with history of gestational diabetes mellitus","volume":"24","author":"Y Wei","year":"2024","journal-title":"BMC Endocr Disord"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12884-025-07267-y","article-title":"The association of inflammatory markers in early pregnancy with the development\nof gestational diabetes: Qazvin maternal and neonatal metabolic study\n(QMNS)","volume":"25","author":"S Hashemipour","year":"2025","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41387-025-00372-z","article-title":"Novel first-trimester serum biomarkers for early prediction of gestational\ndiabetes mellitus","volume":"15","author":"S Tian","year":"2025","journal-title":"Nutr Diabetes"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2337\/db08-1112","article-title":"Hyperglycemia and adverse pregnancy outcome (HAPO) study: associations with\nneonatal anthropometrics","volume":"58","author":"HAPO Study Cooperative Research\nGroup","year":"2009","journal-title":"Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e067946","DOI":"10.1136\/bmj-2021-067946","article-title":"Gestational diabetes mellitus and adverse pregnancy outcomes:\nsystematic review and meta-analysis","volume":"377","author":"W Ye","year":"2022","journal-title":"BMJ"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ajog.2023.08.011","article-title":"Gestational diabetes mellitus and adverse maternal and perinatal outcomes in\ntwin and singleton pregnancies: a systematic review and meta-analysis","volume":"230","author":"E Greco","year":"2024","journal-title":"Am J Obstet Gynecol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.33545\/gynae.2020.v4.i2c.521","article-title":"Risk factors of meconium stained amniotic fluid \u2013 a case control study","volume":"4","author":"C Nirmala","year":"2020","journal-title":"Int J Clin Obstet Gynecol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"S1158","DOI":"10.1016\/j.ajog.2022.11.1283","article-title":"Meconium-stained amniotic fluid","volume":"228","author":"D M Gallo","year":"2023","journal-title":"Am JU Obstet Gynecol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-017-0307-9","article-title":"Serum periostin levels early in pregnancy are significantly altered in women\nwith miscarriage","volume":"15","author":"A Freis","year":"2017","journal-title":"Reprod Biol Endocrinol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"522","DOI":"10.5603\/GP.a2018.0089","article-title":"Gestational diabetes mellitus \u2013 literature review on selected cytokines and\nhormones of confirmed or possible role in its pathogenesis","volume":"89","author":"J \u015awirska","year":"2018","journal-title":"Ginekol Pol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2264447","DOI":"10.1080\/14767058.2023.2264447","article-title":"Periostin promotes extensive neovascularization in placenta\naccreta spectrum disorders via Notch signaling","volume":"36","author":"R Li","year":"2023","journal-title":"J Matern Fetal\nNeonatal Med"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2827-9333.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:38:41Z","timestamp":1791844721000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2827-9333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":27,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,10,12]]},"published-print":{"date-parts":[[2026,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2827-9333","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]}}}