{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:26:14Z","timestamp":1787268374492,"version":"build-2736575974"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die chronisch obstruktive Lungenerkrankung (COPD) ist h\u00e4ufig mit kardiovaskul\u00e4ren Komorbidit\u00e4ten assoziiert, darunter die periphere arterielle Verschlusskrankheit (pAVK). Ziel der Studie war es zu pr\u00fcfen, unter Real-life Bedingungen einer allgemeinmedizinischen Praxis mit pneumologischem Schwerpunkt die Pr\u00e4valenz einer pAVK bei COPD-Patient*innen zu untersuchen und den Zusammenhang zwischen Exazerbationsh\u00e4ufigkeit und -schwere sowie dem Kn\u00f6chel-Arm-Index (ABI) zu analysieren.<\/jats:p>\n                  <jats:p>In dieser retrospektiven, unizentrischen, querschnittlichen Beobachtungsstudie wurden 181 Patient*innen mit einer COPD untersucht. Neben klinischen Parametern und der Exazerbationshistorie der letzten 12 Monate wurden der ABI, die 6-Minuten-Gehstrecke sowie inflammatorische Marker (hs-CRP, Fibrinogen) erhoben. Ein ABI &lt;0,9 wurde als Hinweis auf das Vorliegen einer pAVK gewertet.<\/jats:p>\n                  <jats:p>Bei 25 Patient*innen (13,8%) zeigte sich ein pathologischer ABI im Sinne einer pAVK. Sowohl die H\u00e4ufigkeit als auch insbesondere die Schwere von Exazerbationen waren signifikant mit niedrigeren ABI-Werten assoziiert. Patient*innen mit einer oder mehreren Exazerbationen wiesen im Vergleich zu Patient*innen ohne Exazerbationen signifikant niedrigere ABI-Werte auf. Aktuelle Raucher zeigten insgesamt niedrigere ABI-Werte als Nieraucher; der Zusammenhang zwischen Exazerbationen und ABI war jedoch auch bei Nierauchern nachweisbar. F\u00fcr systemische Entz\u00fcndungsmarker, insbesondere hs-CRP und Fibrinogen, ergaben sich nach Adjustierung keine unabh\u00e4ngigen Assoziationen mit dem ABI.<\/jats:p>\n                  <jats:p>Die pAVK stellt eine h\u00e4ufige Komorbidit\u00e4t bei COPD-Patient*innen dar. Eine h\u00f6here Exazerbationslast ist mit niedrigeren ABI-Werten und damit mit einem erh\u00f6hten Risiko f\u00fcr das Vorliegen einer pAVK assoziiert, auch nach Adjustierung f\u00fcr klassische Risikofaktoren. Die Ergebnisse unterstreichen den Stellenwert der ABI-Messung als einfaches, nicht-invasives Screeninginstrument bei COPD-Patient*innen, insbesondere bei h\u00e4ufigen oder schweren Exazerbationen.<\/jats:p>","DOI":"10.1055\/a-2831-6521","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T23:25:06Z","timestamp":1775172306000},"page":"574-581","source":"Crossref","is-referenced-by-count":0,"title":["Pr\u00e4valenz der peripheren arteriellen Verschlusskrankheit bei Patient*innen mit einer COPD in Abh\u00e4ngigkeit vom Stadium der systemischen Inflammation und der Exazerbationsrate"],"prefix":"10.1055","volume":"80","author":[{"given":"Alexander","family":"Rech","sequence":"additional","affiliation":[{"name":"Praxis Rech, Niedersachsen, Deutschland","place":["Braunschweig"],"department":["Pneumologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina R.","family":"Schwarzbach","sequence":"additional","affiliation":[{"name":"University of Groningen, GR, Netherlands","place":["Groningen"],"department":["Department Clinical & Developmental Neuropsychology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"L\u00fccke","sequence":"additional","affiliation":[{"name":"Otto-von-Guericke-Universit\u00e4t Magdeburg, Medizinische Fakult\u00e4t, Deutschland","place":["Magdeburg"],"department":["Pneumologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Otto-von-Guericke-Universit\u00e4t Magdeburg, Medizinische Fakult\u00e4t, Deutschland","place":["Magdeburg"],"department":["Pneumologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.arbres.2023.02.009","article-title":"Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD 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