{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:08:33Z","timestamp":1789600113229,"version":"build-2803163510"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Our study aims to explore the possible predictive role of Ultrasound Cardiac Output Monitoring (USCOM) parameters toward unfavorable maternal and neonatal complications during labor and delivery in a cohort of women followed by the high-risk pregnancy clinic of a tertiary Italian hospital.<\/jats:p>\n                  <jats:p>A prospective, monocentric descriptive study was run at the AOU Policlinico of Modena. USCOM was implemented in March 2022. Patients in charge of the high-risk pregnancy clinic who received USCOM hemodynamic monitoring during their whole pregnancy were included in the study, with the last examination performed around 37 weeks. By considering the characteristics of labor and delivery, they were divided into two groups (complicated delivery and uncomplicated delivery). Adverse maternal outcomes (AMOs) and adverse neonatal outcomes (ANOs) were prospectively collected from electronic records and analyzed using the R version 4.3.2 statistical software. Continuous variables were presented as means with standard deviations, and categorical variables as counts and percentages.<\/jats:p>\n                  <jats:p>While maternal and perinatal variables, including maternal age, parity, and anthropometric measures, were comparable between groups, significant differences emerged in the USCOM measurements. Cardiac output (CO) was significantly lower in the group with ANO compared with uneventful neonates (4.35\u2009\u00b1\u20091.42 L\/min vs. 4.97\u2009\u00b1\u20091.44 L\/min; adjusted odds ratio [aOR]\u2009=\u20090.79; 95% CI: 0.49, 0.99, p\u2009=\u20090.049). Additionally, peak velocity of ventricular ejection (VPK) was significantly reduced in neonates with ANO compared with neonates without adverse complications (0.92\u2009\u00b1\u20090.27 vs. 1.08\u2009\u00b1\u20090.42; aOR\u2009=\u20090.08, 95% CI: 0.01\u20130.63, p\u2009=\u20090.016). Finally, cardiac index was lower (2.26\u2009\u00b1\u20090.67 vs. 2.54\u2009\u00b1\u20090.74, aOR\u2009=\u20090.49; 95% CI: 0.23\u20131.03, p\u2009=\u20090.060) and systemic vascular resistance was higher (1,800.9\u2009\u00b1\u2009546 vs. 1,638.2\u2009\u00b1\u2009588.4, aOR\u2009=\u20091.00; 95% CI: 1.00\u20131.00, p\u2009=\u20090.245) in the ANO group comparing with those without ANO, although both results do not reach statistical significance.<\/jats:p>\n                  <jats:p>Our findings suggest that the implementation of USCOM in clinical practice may enhance the identification of women at increased risk for ANOs, particularly those presenting with low CO and reduced ventricular peak velocity (VPK) before labor. Further studies with larger sample sizes are needed to confirm and strengthen these observations.<\/jats:p>","DOI":"10.1055\/a-2832-9466","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:10:22Z","timestamp":1773792622000},"page":"1795-1800","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Hemodynamic Assessment at Term for Prediction of Adverse Neonatal Outcomes: The Experience from a Referral Italian Hospital"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8298-9072","authenticated-orcid":false,"given":"Gloria","family":"Guariglia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4536-6465","authenticated-orcid":false,"given":"Serena","family":"Lecis","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Tramontano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Cuoghi Costantini","sequence":"additional","affiliation":[{"name":"Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Bugiolacchi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Pedrini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Ciccarone","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio La","family":"Marca","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Monari","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/uog.4094","article-title":"New Doppler index for prediction of perinatal brain damage in growth-restricted and hypoxic fetuses","volume":"30","author":"D Jugovi\u0107","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"54.e1","DOI":"10.1016\/j.ajog.2014.10.024","article-title":"Is fetal cerebroplacental ratio an independent predictor of intrapartum fetal compromise and neonatal unit admission?","volume":"213","author":"A A Khalil","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"14","key":"ref3","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1055\/a-2267-3994","article-title":"Maternal hemodynamics from preconception to delivery: Research and potential diagnostic and therapeutic implications. 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