{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:54:31Z","timestamp":1790898871122,"version":"4.1.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Postoperative infections remain a significant complication of cesarean delivery (CD), with rates ranging from 3 to 30%. These infections increase healthcare costs, prolong recovery, and negatively impact maternal outcomes. Identifying risk factors for infection might help guide preventative strategies to mitigate this burden. The primary aim of this study was to develop and validate a predictive model for infection after CD using preoperative and perioperative characteristics.<\/jats:p>\n                  <jats:p>This study was a secondary analysis of a multicenter randomized trial comparing tranexamic acid versus placebo to prevent postpartum hemorrhage in individuals undergoing either scheduled or unscheduled CD. The primary outcome of this analysis was a composite of surgical site infection, endometritis, or pelvic abscess diagnosed within 6 weeks postpartum. Univariable and multivariable bootstrapped logistic regression models with stepwise selection were used to identify predictors of infection. Model performance was evaluated using the receiver operator curve area under the curve (AUC).<\/jats:p>\n                  <jats:p>Of the 10,995 participants, 287 (2.6%) developed an infection. Significant predictors included tobacco use (OR: 1.67, 95% CI: 1.21\u20132.31), BMI at delivery \u2265 30\u2009kg\/m2 (OR: 1.41, 95% CI: 1.04\u20131.91), labor before cesarean (OR: 1.71, 95% CI: 1.33\u20132.18), longer surgical duration (OR: 1.01 per minute, 95% CI: 1.01\u20131.02), uterine incision extension (OR: 1.54, 95% CI: 1.02\u20132.34), and the use of uterotonics other than oxytocin (OR: 1.48, 95% CI: 1.09\u20132.02). The predictive model demonstrated modest discrimination with an AUC of 0.64 (95% CI: 0.61\u20130.68).<\/jats:p>\n                  <jats:p>Multiple modifiable and nonmodifiable factors influence infection after CD. This predictive model offers a framework for assessing individualized risk, though its modest performance indicates that further refinement is necessary before it can be confidently applied in clinical decision-making. Future research should aim to enhance predictive accuracy and explore whether risk stratification meaningfully informs prevention or patient counseling strategies.<\/jats:p>","DOI":"10.1055\/a-2835-1796","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:57:38Z","timestamp":1773878258000},"page":"1884-1891","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Infection after Cesarean Delivery"],"prefix":"10.1055","volume":"43","author":[{"given":"Antonio F.","family":"Saad","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch, Galveston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula L.","family":"McGee","sequence":"additional","affiliation":[{"name":"The George Washington University Biostatistics Center, Washington, District of Columbia, United 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States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Gyamfi-Bannerman","sequence":"additional","affiliation":[{"name":"Columbia University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneet P.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston, Children's Memorial Hermann Hospital, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torri D.","family":"Metz","sequence":"additional","affiliation":[{"name":"University of Utah Health Sciences Center, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara","family":"Rood","sequence":"additional","affiliation":[{"name":"The Ohio State University, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight J.","family":"Rouse","sequence":"additional","affiliation":[{"name":"Brown University, Women and Infants Hospital of Rhode Island, Providence, Rhode Island, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Bailit","sequence":"additional","affiliation":[{"name":"MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Grobman","sequence":"additional","affiliation":[{"name":"Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyagriv N.","family":"Simhan","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units 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